The Use of Restricted Significance Tests in Clinical Trials / Edition 1

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This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved. Secondly, the book seeks to develop the specific tools of analysis which can be derived from Neyman's model of restricted tests. The book is based on the author's many years of experience of clinical trials. Throughout, examples are used from a variety of types of study. As a result, all statisticians and research scientists who work on clinical trials will find this presentation clear and accessible, and very relevant to their own research interests.
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Editorial Reviews

Presents a clear account of the design and analysis of experiments in randomized clinical trials that stresses the foundational issues involved. The author also seeks to develop the specific tools of analysis that can be derived from Neyman's model of restricted tests. Examples are used throughout from a variety of types of studies. Chapter topics include probability models and clinical medicine, significance tests versus hypothesis tests, reconciling Fisher and Neyman, and combining data across measures. Annotation c. Book News, Inc., Portland, OR (
From the Publisher
"...A broad range of statistical methodologies is surveyed including restricted chi-square tests, normal theory tests, nonparametric tests, permutation and resampling methods and Bayesian estimation...For anyone who wants to think deeply about the basic issues involving the design and analysis of clinical trials, this book is a must read.."(Zentralblatt für Mathematik)
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Product Details

  • ISBN-13: 9780387977980
  • Publisher: Springer New York
  • Publication date: 8/6/1992
  • Series: Statistics for Biology and Health Series
  • Edition description: 1992
  • Edition number: 1
  • Pages: 173
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.50 (d)

Table of Contents

Pt. 1 Philosophical and Scientific Problems when Applying Statistical Methods to Clinical Data
Ch. 1 The Randomized Controlled Clinical Trial 3
Ch. 2 Probability Models and Clinical Medicine 10
Ch. 3 Significance Tests Versus Hypothesis Tests 22
Ch. 4 Neyman's Insights 30
Ch. 5 Reconciling Fisher and Neyman 39
Pt. 2 Techniques for Applying Restricted Tests to Data from Randomized Controlled Clinical Trials
Ch. 6 Continuous Measures Taken over Time 49
Ch. 7 Combining Data Across Measures 60
Ch. 8 Counts of Events 78
Ch. 9 Permutation Tests and Resampling Techniques 89
Ch. 10 Neyman's Restricted Chi Square Tests 97
Ch. 11 Miscellaneous Methods for Increasing Power 104
Ch. 12 Bayesian Estimation 115
Ch. 13 An Example of the Type of Analysis Suggested in This Book 126
References 161
Index 171
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