Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice, Second Edition / Edition 2

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The “essential” companion to the landmark Users' Guides to the Medical Literature - completely revised and updated!


"This second edition is even better than the original. Information is easier to find and the additional resources that will be available at will provide readers with a one-stop source for evidence-based medicine."—Doody's Review Service

Evidence-based medicine involves the careful interpretation of medical studies and its clinical application. And no resource helps you do it better-and faster-than Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice.

This streamlined reference distills the most clinically-relevant coverage from the parent Users' Guide Manual into one highly-focused, portable resource. Praised for its clear explanations of detailed statistical and mathematical principles, The Essentials concisely covers all the basic concepts of evidence-based medicine—everything you need to deliver optimal patient care.

It's a perfect at-a-glance source for busy clinicians and students, helping you distinguish between solid medical evidence and poor medical evidence, tailor evidence-based medicine for each patient, and much more. Now in its second edition, this carry-along quick reference is more clinically relevant—and more essential—than ever!


  • Completely revised and updated with all new coverage of the basic issues in evidence-based medicine in patient care
  • Abundant real-world examples drawn from the medical literature are woven throughout, and include important related principles and pitfalls in using clinical research in patient care decisions
  • Edited by over 60 internationally recognized editors and contributors from around the globe
  • Also look for, a new interactive database for the best practice of evidence based medicine.
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Editorial Reviews

Doody's Review Service
Reviewer: Kristi J. Ferguson, PhD (University of Iowa Carver College of Medicine)
Description: This is the second edition of an excellent book that provides practical advice about evidence-based medicine to clinicians. The authors have provided new examples for many of the tests, and have significantly improved the organization of the material over the 2002 first edition.
Purpose: The purpose is to help clinicians make efficient use of the published literature to guide patient care. Including this information in a single resource, to be integrated with a number of online resources, makes this an important contribution to the field. The advanced material for those interested in covering certain issues in more depth is very helpful.
Audience: Practicing clinicians in all specialties are the intended audience. The authors are highly regarded in the field, and have used their experience in teaching these principles to practicing clinicians to improve the usefulness of their book.
Features: The book covers all steps in finding and evaluating evidence for clinical care, starting with identifying the problem, defining the question, finding the evidence, evaluating the evidence, and applying it to patient care. The pocket cards are useful summaries of the important information. The sample search strategies will be especially useful to clinicians who do not have much experience with searching online databases. The glossary is well organized.
Assessment: This second edition is even better than the original. Information is easier to find and the additional resources that will be available at will provide readers with a one-stop source for evidence-based medicine.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780071590389
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 5/21/2008
  • Series: Jama and Archives Journals
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 380
  • Sales rank: 532,651
  • Product dimensions: 4.50 (w) x 7.00 (h) x 0.80 (d)

Meet the Author

Gordon Guyatt, MD, MSc

Departments of Clinical Epidemiology and Biostatistics and Medicine

Faculty of Health Sciences

McMaster University

Hamilton, Ontario

Drummond Rennie, MD

JAMA, Chicago, IL

Philip R. Lee Institute for Health Policy Studies

University of California, San Francisco

San Francisco, CA

Maureen O. Meade, MD, FRCPC, MSc

Departments of Medicine and Clinical Epidemiology and Biostatistics

Faculty of Health Sciences

McMaster University

Hamilton, Ontario

Deborah J. Cook, MD, MSc

Department of Medicine and Clinical Epidemiology and Biostatistics

Faculty of Health Sciences

McMaster University

Hamilton, Ontario

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Table of Contents



1. How to Use the Medical Literature—and This Book—to Improve Your Patient Care
2. The Philosophy of Evidence-Based Medicine
3. What Is the Question?
4. Finding the Evidence
5. Why Study Results Mislead: Bias and Random Error
6. Therapy (Randomized Trials)
7. Does Treatment Lower Risk? Understanding the Results
8. Confidence Intervals
9. Harm (Observational Studies)
10. The Process of Diagnosis
11. Differential Diagnosis
12. Diagnostic Tests
13. Prognosis
14. Summarizing the Evidence
15. How to Use a Patient Management Recommendation

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