Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, Second Edition / Edition 2

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The #1 guide to the principles and clinical applications of evidence-based medicine has just gotten better!

A Doody's Core Title ESSENTIAL PURCHASE for 2011!

No other resource helps you to put key evidence-based medicine protocols into daily clinical practice better than Users' Guides to the Medical Literature.

An instant classic in its first edition, this detailed, yet highly readable reference demystifies the statistical, analytical, and clinical principles of evidence-based medicine, giving you a hands-on, practical resource that no other text can match.

Here, you'll learn how to distinguish solid medical evidence from poor medical evidence, devise the best search strategies for each clinical question, critically appraise the medical literature, and optimally tailor evidence-based medicine for each patient. The new second edition of this landmark resource is now completely revised and refreshed throughout, with expanded coverage of both basic and advanced issues in using evidence-based medicine in clinical practice.


  • Completely revised and updated to reflect the enormous expansion in medical research and evidence-based resources since the first edition
  • Innovative organization guides you from the fundamentals of using the medical literature to the more advanced strategies and skills for use in every day patient care situations
  • Abundant and current real-world examples drawn from the medical literature are woven throughout, and include important related principles and pitfalls in using medical literature in patient care decisions
  • Practical focus on the key issues in evidence-based practice: What are the results? Are the results valid? How to I apply to results to the care of my patients?
  • More than 60 internationally recognized editors and contributors from the U.S., Canada, South America, Europe, and Asia — the best of the best in the discipline
  • NEW coverage on how to:

    —Avoid being misled by biased presentations of research findings

    —Interpret the significance of clinical trials that are discontinued early

    —Influence clinician behavior to improve patient care

    —Apply key strategies for teaching evidence-based medicine

Also look for, a new interactive database for the best practice of evidence based medicine.

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Product Details

  • ISBN-13: 9780071590341
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 5/21/2008
  • Series: Jama and Archives Journals
  • Edition description: Older Edition
  • Edition number: 2
  • Pages: 860
  • Product dimensions: 5.90 (w) x 8.90 (h) x 1.30 (d)

Meet the Author

Gordon Guyatt, MD, MSc

Departments of Clinical Epidemiology and Biostatistics and Medicine

Faculty of Health Sciences

McMaster University

Hamilton, Ontario

Drummond Rennie, MD

JAMA, Chicago, IL

Philip R. Lee Institute for Health Policy Studies

University of California, San Francisco

San Francisco, CA

Maureen O. Meade, MD, FRCPC, MSc

Departments of Medicine and Clinical Epidemiology and Biostatistics

Faculty of Health Sciences

McMaster University

Hamilton, Ontario

Deborah J. Cook, MD, MSc

Department of Medicine and Clinical Epidemiology and Biostatistics

Faculty of Health Sciences

McMaster University

Hamilton, Ontario

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Table of Contents

Part A. The Foundations
1. How to Use the Medical Literature—and This Book—to Improve Your Patient Care
2. The Philosophy of Evidence-Based Medicine
3. What Is the Question?
4. Finding the Evidence
5. Why Study Results Mislead: Bias and Random Error
Part B. Therapy
6. Therapy (Randomized Trials)
7. Does Treatment Lower Risk? Understanding the Results
8. Confidence Intervals
9. Advanced Topics in the Validity of Therapy Trials
  9.1 An Illustration of Bias and Random Error
  9.2 Surprising Results of Randomized Trials
  9.3 Randomized Trials Stopped Early for Benefit
  9.4 The Principle of Intention to Treat
  9.5 N-of-1 Randomized Controlled Trials
  9.6 Clinical Decision Support Systems
10. Advanced Topics in the Results of Therapy Trials
  10.1 Hypothesis Testing
  10.2 Understanding the Results: More About Odds Ratios
  10.3 What Determines the Width of the Confidence Interval?
  10.4 Composite endpoints
  10.5 Measuring Patients’ Experience
11. Advanced Topics in Applying the Results of Therapy Trials
  11.1 Applying Results to Individual Patients
  11.2 Example Numbers Needed to Treat
  11.3 Dealing with Misleading Presentations of Clinical Trial Results
  11.4 Surrogate Outcomes
  11.5 Qualitative Research
Part C. Harm (Observational Studies)
12. Harm (Observational Studies)
13. Advanced Topics in Harm: Correlation and Regression
Part D. Diagnosis
14. The Process of Diagnosis
15. Differential Diagnosis
16. Diagnostic Tests
17. Advanced Topics in Diagnosis
  17.1 Spectrum Bias
  17.2 Examples of Likelihood Ratios
  17.3 Measuring Agreement Beyond Chance
  17.4 Clinical Prediction Rules
Part E. Prognosis
18. Prognosis
Part F. Summarizing the Evidence
19. Summarizing the Evidence
20. Advanced Topics in Systematic Reviews
  20.1 Reporting Bias
  20.2 Fixed-Effects and Random-Effects Models
  20.3 Making Sense of Variability in Study Results
  20.4 When to Believe a Subgroup Analysis
Part G. Moving From Evidence to Action
21. How to Use a Patient Management Recommendation
22. Advanced Topics in Moving from Evidence to Action
  22.1 Economic Analysis
  22.2 Decision Making and the Patient
  22.3 Moving From Evidence to Action: Recommendations About Screening
  22.4 Grading Recommendations
  22.5 Drug Class Effects
  22.6 Parallel but Separate Goals: Evidence-Based Practitioners and Evidence-Based Care
  22.7 Changing Behavior to Apply Best Evidence in Practice
  22.8 Teachers’ Guides to the Users' Guides

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