Using Mass Spectrometry for Drug Metabolism Studies

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Overview

Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field.

Using Mass Spectrometry for Drug Metabolism Studies is an excellent resource for professionals in the fields of mass spectrometry and drug metabolism. It offers current knowledge in stand—alone chapters that address specific topics thoroughly enough to be read independently, with notes and references to other chapters for further reading. The first eight chapters discuss current topics regarding the use of MS for analyzing various types of in vitro and in vivo drug metabolism samples and the final four chapters describe the latest MS technology and its uses. In each chapter, expert authors demonstrate how to apply MS to determine drug metabolism parameters. They also explain the different drug metabolism concepts and their importance.

Although there are a few books currently on the market that address this topic, they are rapidly becoming out-of-date. This book gives drug researchers and pharmacokineticists the latest information available on this important technology.

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Product Details

  • ISBN-13: 9780849319631
  • Publisher: CRC Press
  • Publication date: 12/17/2004
  • Pages: 384
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.00 (d)

Table of Contents

Bioanalytical Assays in a Drug Discovery Environment; Walter A. Korfmacher
Drug Metabolism In-vitro and In-vivo Results: How do these Data Support Drug Discovery?; Thomas N. Thompson
High Throughput Strategies forIn Vitro ADME Assays: How Fast Can We Go?;Dan Kassel,
Matrix Effects: Causes and Solutions; Hong Mei
Direct Plasma Analysis Systems; Yunsheng Hsieh
Acyl Glucuronides—Assays and Issues; Sam Wainhaus
Utilizing Higher Mass Resolution in Quantitative Assays; Xiaoying Xu
Special Requirements for Metabolite Characterization; Kathleen Cox
APPI: A New Ionization Source for LC-MS/MS Assays; Yunsheng Hsieh Q Trap MS: a New Tool for Metabolite Identification; Gerard Hopfgartner and Manfred Zell
MS Imaging: New Technology Provides New Opportunities; Michelle L. Reyzer and Richard M. Caprioli Understanding the Role and Potential of Infusion Nanoelectrospray Ionization for Pharmaceutical Bioanalysis; Bradley L. Ackermann and Jean-Marie Dethy

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