Vanadium Compounds: Biochemical and Therapeutic Applications

by Ashok K. Srivastava (Editor), Jean-Louis Chiasson (Editor)

Overview

The papers in this volume comprise invited reviews as well as original research papers presented at the Vanadium Symposium held July 29-31, 1994.
Vanadium is a trace element and its compounds have been shown to exert a wide variety of insulin-like effects including the ability to lower hyperglycemia in several experimental models of diabetes mellitus. Because of the possibility that vanadium compounds may be able to serve as potential therapeutic agents for the treatment of diabetes, and possibly other diseases, this trace element has attracted the attention of biomedical researchers from a variety of fields. The Vanadium Symposium 1994 was therefore organized to facilitate exchange of ideas and increase interaction among researchers of different disciplines actively engaged in studying the biological actions of vanadium compounds.
The papers are written by leading vanadium researchers and are grouped into three main sections: the chemistry, biochemical and physiological aspects, and potential therapeutic use and toxic effects of vanadium compounds. A good source of information on vanadium chemistry and biology.

Product Details

ISBN-13:	9780792337621
Publisher:	Springer US
Publication date:	04/30/1996
Series:	Developments in Molecular and Cellular Biochemistry , #16
Edition description:	1995
Pages:	246
Product dimensions:	8.50(w) x 11.02(h) x 0.02(d)

Table of Contents

I: Chemistry.- The chemistry of peroxovanadium compounds relevant to insulin mimesis.- Vanadium chemistry and biochemistry of relevance for use of vanadium compounds as antidiabetic agents.- Peroxo heteroligand vanadates(V): Synthesis, spectra-structure relationships, and stability toward decomposition.- Chemically and phohemically initiated DNA cleavage by an insulin-mimetic bisperoxovanadium complex.- II: Biochemical and physiological studies.- Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases.- Peroxovanadium compounds: Biological actions and mechanism of insulin-mimesis.- Unique and selective mitogenic effects of vanadate on SV40-transformed cells.- Vanadium salts stimulate mitogen-activated protein (MAP) kinases and ribosomal S6 kinases.- Protective effect of vanadate on oxyradical-induced changes in isolated perfused heart.- In vivo effects of vanadate on hepatic glycogen metabolizing and lipogenic enzymes in insulin-dependent and insulin-resistant diabetic animals.- The relationship between insulin and vanadium metabolism in insulin target tissues.- Modulation of insulin action by vanadate: Evidence of a role for phosphotyrosine phosphatase activity to alter cellular signaling.- Reversal of defective G-proteins and adenylyl cyclase/cAMP signal transduction in diabetic rats by vanadyl sulphate therapy.- Effects of vanadate on the expression of genes involved in fuel homeostasis in animal models of Type I and Type II diabetes.- Decrease in protein tyrosine phosphatase activities in vanadate-treated obese Zucker (fa/fa) rat liver.- Evidence for selective effects of vanadium on adipose cell metabolism involving actions on cAMP-dependent proteinkinase.- The enhancement by pervanadate of tyrosine phosphorylation on prostatic proteins occurs through the inhibition of membrane-associated tyrosine phosphatases.- Contractile effects of vanadate on aorta rings from virgin and pregnant rats.- In vivo modulation of N-myristoyltransferase activity by orthovanadate.- Regulation and control of glucose overutilization in erythrocytes by vanadate.- In vitro and in vivo antineoplastic effects of ortrovanadate.- Membrane — vanadium interaction: A toxicokinetic evaluation.- III: Potential use in therapy and toxicological studies.- Increased potency of vanadium using organic ligands.- In vivo effects of peroxovanadium compounds in BB rats.- Long-term antidiabetic activity of vanadyl after treatment withdrawal: Restoration of insulin secretion?.- Long-term correction of STZ-diabetic rats after short-term i.p. VOSO4 treatment: Persistence of insulin secreting capacities assessed by isolated pancreas studies.- Antihypertensive effects of vanadium compounds in hyperinsulinemic, hypertensive rats.- Vanadate induces normolipidemia and a reduction in the levels of hepatic iipogenic enzymes in obese Zucker rat.- In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus.- Toxicology of vanadium compounds in diabetic rats: The action of chelating agents on vanadium accumulation.- Index to Volume 153.

Editorial Reviews

This special issue of Molecular and Cellular Biochemistry; An International Journal for Chemical Biology in Health and Disease, v.153, nos.1-2, 1995, contains invited reviews as well as original research papers presented at the Vanadium Symposium 1994, held July 1994, in Montreal. Vanadium is a trace element attracting the attention of biomedical researchers from a variety of fields, because its compounds have been shown to exert a variety of insulin-like effects, including the ability to lower hyperglycemia in several experimental models of diabetes mellitus. Thirty contributions are grouped in three sections, the first dealing with the chemistry, the second containing studies on the biochemical and physiological aspects, and the last addressing the potential therapeutic use and toxic effects of vanadium compounds. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews