Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management / Edition 1

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This volume provides a synthesis of the compelling research that has emerged describing the intricate interrelationships between the pathophysiology of vascular Dementia (VaD) and neuropathological features of other degenerative diseases. Binding together clinical relevant aspects of the disease, this book integrates findings from studies that have focused on the neuropathology, neuropsychology and behavioral neurology of VaD. Unique in its presentation that reviews VaD in depth from basic etiology to clinical practice, this volume will be extremely attractive to both clinicians and researchers in general and behavioral neurology, neuropsychiatry, geriatric psychiatry and clinical neuropsychology.

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Editorial Reviews

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"This book is an update on the link between cerebrovascular disease and dementia. … The book has several strengths. … The diagrams, images, and tables are generally thoughtful. … Overall, Vascular Dementia is a valuable textbook. After reviewing it, I felt as if I had been brought up to date on a variety of topics related to the disorder … . I would recommend the book to geriatricians, internists, and neurologists who care for elderly patients as well as to clinical researchers in geriatric neurology." (Carol F. Lippa, New England Journal of Medicine, June, 2005)

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Product Details

  • ISBN-13: 9781588293664
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 10/20/2004
  • Series: Current Clinical Neurology Series
  • Edition description: 2005
  • Edition number: 1
  • Pages: 372
  • Product dimensions: 7.22 (w) x 10.26 (h) x 1.03 (d)

Table of Contents

1 The aging population and the relevance of vascular dementia 3
2 Clinical forms of vascular dementia 7
3 The neuropathological substrates of vascular-ischemic dementia 23
4 Diagnosis of vascular dementia : conceptual challenges 57
5 Cerebral hemodynamics in the elderly 75
6 The CADASIL syndrome and other genetic causes of stroke and vascular dementia 87
7 Estrogen, the cerebrovascular system, and dementia 99
8 Effects of hypertension in young adult and middle-aged Rhesus monkeys 113
9 The cognitive profile of vascular dementia 131
10 Progression of cognitive impairments associated with cerebrovascular disease 145
11 Neuropsychiatric correlates of vascular injury : vascular dementia and related neurobehavioral syndromes 157
12 Functional impairment in vascular dementia 171
13 Functional brain imaging of cerebrovascular disease 181
14 Contributions of subcortical lacunar infarcts to cognitive impairment in older persons 211
15 White matter hyperintensities and cognition 223
16 Poststroke dementia : the role of strategic infarcts 231
17 Understanding incidence and prevalence rates in mixed dementia 245
18 Vascular basement membrane abnormalities and Alzheimer's disease 257
19 Amyloid beta and the cerebral vasculature 267
20 Cerebrovascular disease and the expression of Alzheimer's disease 275
21 The neuropsychological differentiation between Alzheimer's disease and subcortical vascular dementia 281
22 Pharmacological treatment of vascular dementia 297
23 Understanding and managing caregiver burden in cerebrovascular disease 305
24 Quality of life in patients with vascular dementia 323
25 Approaches to neuroprotection and recovery enhancement after acute stroke 331
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