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Vascular Development / Edition 1

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The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions.

In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups.

The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues.

The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation.

While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues.

With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

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Product Details

  • ISBN-13: 9780470034286
  • Publisher: Wiley
  • Publication date: 9/17/2007
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 260
  • Product dimensions: 6.26 (w) x 9.21 (h) x 0.69 (d)

Meet the Author

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

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Table of Contents

Chair’s introduction (Christer Betsholtz).

The control of endothelial cell functions by adherens junctions (Maria Grazia Lampugnani and Elisabetta Dejana).


The role of Egfl 7 in vascular morphogenesis (Maike Schmidt, Ann De Mazière, Tanya Smyczek, Alane Gray, Leon Parker, Ellen Filvaroff, Dorothy French, Suzanne van Dijk, Judith Klumperman and Weilan Ye).


A model of intussusceptive angiogenesis (Max Levin, Andrew J. Ewald, Martin McMahon, Zena Werb and Keith Mostov).


Vascular lumen formation from a cell biological perspective (Tomas Kucera, Jan Eglinger, Boris Strilic and Eckhard Lammert).


The genetics of vasculogenesis (Christopher J. Drake, Paul A. Fleming and W. Scott Argraves).


 Negative regulators of vessel patterning (Anne Eichmann).


Lymphangiogenesis in development and disease (Taija Mäkinen and Kari Alitalo).


Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis (Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston).


HIF in vascular development and tumour angiogenesis (Georg Breier, Alexander H. Licht, Anne Klotzsche, Ben Wielockx and Zuzana Kirsnerova).


Imaging the developing lymphatic system using the zebrafish (Karina Yaniv, Sumio Isogai, Daniel Castranova, Louis Dye, Jiro Hitomi and Brant M. Weinstein).  


Signalling pathways regulating cardiac neural crest migration and differentiation (Frances High and Jonathan A. Epstein).


Investigation of the angiogenic programme with tissue-specifi c and inducible genetic approaches in mice (Ralf H. Adams).


Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity (Gary K. Owens).


Growth factor gradients in vascular patterning (Andrea Lundkvist, Sunyoung Lee, Patrik Andersson, Fredrik Wolfhagen, Nico Van Rooijen, Peter Carmeliet, Luisa Iruela-Arispe, Christer Betsholtz and Holger Gerhardt).


Endothelial cell promotion of early liver and pancreas development (Deborah A. Freedman, Yasushige Kashima and Kenneth S. Zaret).


Embryonic development and malformation of lymphatic vessels (Jörg Wilting, Kerstin Buttler, Jochen Rössler, Susanne Norgall, Lothar Schweigerer, Herbert A. Weich and Maria Papoutsi).


Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse (Joaquim Miguel Vieira, Quenten Schwarz and Christiana Ruhrberg).


Final discussion.

Tracheal tube development in Drosophila.

Closing remarks.

Index of contributors.

Subject index.

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