Vascular Disease and Injury: Preclinical Research / Edition 1by Daniel I. Simon
Pub. Date: 11/28/2000
Publisher: Springer-Verlag New York, LLC
Vascular Disease and Injury: Pre-clinical Research provides the vascul ar biologist and cardiovascular clinician with a comprehensive compila tion of experimental models investigating acute mechanical injury and repair (i.e., restenosis), arterial thrombosis, atherosclerosis, vascu lar disease in transplanted vessels, and vascular disease in systemic and
Vascular Disease and Injury: Pre-clinical Research provides the vascul ar biologist and cardiovascular clinician with a comprehensive compila tion of experimental models investigating acute mechanical injury and repair (i.e., restenosis), arterial thrombosis, atherosclerosis, vascu lar disease in transplanted vessels, and vascular disease in systemic and pulmonary hypertension. Particular focus will be dedicated to mous e models of human vascular disease given the availability of key trans genic and "knock-out" strains. Each individual chapter provides the va scular biologist investigator with essential "how-to" information to g et a particular vascular model up and running. For the cardiovascular clinician, experimental observations will be linked to translational t herapeutics.
Table of Contents
Part I. Acute Mechanical Injury and Vascular Repair. Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries, Frederick G.P. Welt, Elazer R. Edelman, and Campbell Rogers. The Porcine Model of Coronary Restenosis, Robert S. Schwartz, Birgit Kantor, and David R. Holmes Jr. Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies, Andrew J. Carter. Nonhuman Primate Models of Arterial Injury and Repair, Mark Nedelman, Christopher Horvarth, and Campbell Rogers. Experimental Models of Arteriovenous Grafting, Afshin Ehsan, Michael J. Mann, and Victor J. Dzau. Wire Denudation and Ligation Models of the Mouse Carotid Artery, Volkhard Lindner. Endothelial Denudation and Arterial Dilation in the Mouse, Zhiping Chen, Campbell Rogers, and Daniel I. Simon. Vascular Phohemical Injury in the Mouse, Daniel T. Eitzman and Randal J. Westrick. Mouse Model of Transluminal Femoral Artery Injury, Ernane D. Reis, Susan S. Smyth, and Barry S. Coller. Part II. Models of Arterial Thrombosis. A Murine Model of Arterial Injury and Thrombosis, William P. Fay, Andrew C. Parker, and Yanhong Zhu. Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls, John D. Folts. Part III. Chronic Atherosclerotic Models. Mouse Models of Atherosclerosis, Wulf Palinski, Claudio Napoli, and Peter D. Reaven. Rabbit Models of Atherosclerosis, Masanori Aikawa, Yoshihiro Fukumoto, Elena Rabkin, and Peter Libby. Atherosclerosis in Nonhuman Primates, David Kritchevsky and Robert J. Nicolosi. Part IV. Vascular Disease in Transplanted Vessels. Murine Carotid Loop Model of Transplant Vascular Disease, Victor Chengwei Shi and Jennifer L. Hoover. Murine Heterotopic Model of Transplant Arteriopathy, Richard N. Mitchell. Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation, Raymond H. Chen and David H. Adams. Part V. Vascular Disease in Models of Arterial Hypertension. Methods for Examining Cerebrovascular Disease in Experimental Models of Hypertension, Gary L. Baumbach. Monocrotaline-Induced Pulmonary Hypertension in Rats, Marlene Rabinovitch. Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization, Barbara Meyrick and Elena Tchekneva. Part VI. Animal Care and Tissue Processing. Veterinary Issues and Anesthesia Options, Robert P. Marini. Histological and Immunohishemical Methods for Vascular Animal Model Studies, Philip Seifert, Campbell Rogers, and Elazer R. Edelman. Index.
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