Vascular Disease and Injury: Preclinical Research / Edition 1

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Vascular Disease and Injury: Pre-clinical Research provides the vascul ar biologist and cardiovascular clinician with a comprehensive compila tion of experimental models investigating acute mechanical injury and repair (i.e., restenosis), arterial thrombosis, atherosclerosis, vascu lar disease in transplanted vessels, and vascular disease in systemic and pulmonary hypertension. Particular focus will be dedicated to mous e models of human vascular disease given the availability of key trans genic and "knock-out" strains. Each individual chapter provides the va scular biologist investigator with essential "how-to" information to g et a particular vascular model up and running. For the cardiovascular clinician, experimental observations will be linked to translational t herapeutics.

The book contains black-and-white illustrations.

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Editorial Reviews

A practical guide to the key animal models used in vascular disease research. The 22 chapters examine issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Models using transgenic mice are a particular focus of each section. Each chapter provides equipment lists; sources of animals, diet, and reagents; and schematic diagrams. Key points regarding survival strategy, choice of anesthesia and analgesia, and veterinary issues are also reviewed, as are the basic histopathologic methods for tissue harvesting, fixation, and electron microscopy preparation. Topics include the porcine model of coronary restenosis, experimental models of arteriovenous grafting, a murine cartoid loop model of transplant vascular disease, and hyperacute vascular rejection in pig to primate xenotransplantation. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780896037533
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/28/2000
  • Series: Contemporary Cardiology Series
  • Edition description: 2001
  • Edition number: 1
  • Pages: 348
  • Product dimensions: 6.20 (w) x 9.20 (h) x 1.00 (d)

Table of Contents

Color Plates
1 Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries 3
2 The Porcine Model of Coronary Restenosis 19
3 Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies 43
4 Nonhuman Primate Models of Arterial Injury and Repair 53
5 Experimental Models of Arteriovenous Grafting 61
6 Wire Denudation and Ligation Models of the Mouse Carotid Artery 79
7 Endothelial Denudation and Arterial Dilation in the Mouse 87
8 Vascular Photochemical Injury in the Mouse 95
9 Mouse Model of Transluminal Femoral Artery Injury 103
10 A Murine Model of Arterial Injury and Thrombosis 117
11 Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls 127
12 Mouse Models of Atherosclerosis 149
13 Rabbit Models of Atherosclerosis 175
14 Atherosclerosis in Nonhuman Primates 193
15 Murine Carotid Loop Model of Transplant Vascular Disease 207
16 Murine Heterotopic Model of Transplant Arteriopathy 215
17 Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation 231
18 Methods of Examining Cerebrovascular Disease in Experimental Models of Hypertension 247
19 Monocrotaline-Induced Pulmonary Hypertension in Rats 261
20 Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization 281
21 Veterinary Issues and Anesthesia Options 303
22 Histological and Immunohistochemical Methods for Vascular Animal Model Studies 325
Index 339
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