Vascular Disease and Injury: Preclinical Research / Edition 1

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Vascular Disease and Injury: Pre-clinical Research provides the vascul ar biologist and cardiovascular clinician with a comprehensive compila tion of experimental models investigating acute mechanical injury and repair (i.e., restenosis), arterial thrombosis, atherosclerosis, vascu lar disease in transplanted vessels, and vascular disease in systemic and pulmonary hypertension. Particular focus will be dedicated to mous e models of human vascular disease given the availability of key trans genic and "knock-out" strains. Each individual chapter provides the va scular biologist investigator with essential "how-to" information to g et a particular vascular model up and running. For the cardiovascular clinician, experimental observations will be linked to translational t herapeutics.

The book contains black-and-white illustrations.

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Editorial Reviews

A practical guide to the key animal models used in vascular disease research. The 22 chapters examine issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Models using transgenic mice are a particular focus of each section. Each chapter provides equipment lists; sources of animals, diet, and reagents; and schematic diagrams. Key points regarding survival strategy, choice of anesthesia and analgesia, and veterinary issues are also reviewed, as are the basic histopathologic methods for tissue harvesting, fixation, and electron microscopy preparation. Topics include the porcine model of coronary restenosis, experimental models of arteriovenous grafting, a murine cartoid loop model of transplant vascular disease, and hyperacute vascular rejection in pig to primate xenotransplantation. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9781617371691
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/9/2010
  • Series: Contemporary Cardiology Series
  • Edition description: Softcover reprint of the original 1st ed. 2001
  • Edition number: 1
  • Pages: 348
  • Product dimensions: 0.82 (w) x 6.00 (h) x 9.00 (d)

Table of Contents

Part I. Acute Mechanical Injury and Vascular Repair. Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries, Frederick G.P. Welt, Elazer R. Edelman, and Campbell Rogers. The Porcine Model of Coronary Restenosis, Robert S. Schwartz, Birgit Kantor, and David R. Holmes Jr. Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies, Andrew J. Carter. Nonhuman Primate Models of Arterial Injury and Repair, Mark Nedelman, Christopher Horvarth, and Campbell Rogers. Experimental Models of Arteriovenous Grafting, Afshin Ehsan, Michael J. Mann, and Victor J. Dzau. Wire Denudation and Ligation Models of the Mouse Carotid Artery, Volkhard Lindner. Endothelial Denudation and Arterial Dilation in the Mouse, Zhiping Chen, Campbell Rogers, and Daniel I. Simon. Vascular Phohemical Injury in the Mouse, Daniel T. Eitzman and Randal J. Westrick. Mouse Model of Transluminal Femoral Artery Injury, Ernane D. Reis, Susan S. Smyth, and Barry S. Coller. Part II. Models of Arterial Thrombosis. A Murine Model of Arterial Injury and Thrombosis, William P. Fay, Andrew C. Parker, and Yanhong Zhu. Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls, John D. Folts. Part III. Chronic Atherosclerotic Models. Mouse Models of Atherosclerosis, Wulf Palinski, Claudio Napoli, and Peter D. Reaven. Rabbit Models of Atherosclerosis, Masanori Aikawa, Yoshihiro Fukumoto, Elena Rabkin, and Peter Libby. Atherosclerosis in Nonhuman Primates, David Kritchevsky and Robert J. Nicolosi. Part IV. Vascular Disease in Transplanted Vessels. Murine Carotid Loop Model of Transplant Vascular Disease, Victor Chengwei Shi and Jennifer L. Hoover. Murine Heterotopic Model of Transplant Arteriopathy, Richard N. Mitchell. Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation, Raymond H. Chen and David H. Adams. Part V. Vascular Disease in Models of Arterial Hypertension. Methods for Examining Cerebrovascular Disease in Experimental Models of Hypertension, Gary L. Baumbach. Monocrotaline-Induced Pulmonary Hypertension in Rats, Marlene Rabinovitch. Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization, Barbara Meyrick and Elena Tchekneva. Part VI. Animal Care and Tissue Processing. Veterinary Issues and Anesthesia Options, Robert P. Marini. Histological and Immunohishemical Methods for Vascular Animal Model Studies, Philip Seifert, Campbell Rogers, and Elazer R. Edelman. Index.

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