Ventilator-Induced Lung Injury

Overview

This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Considering many emerging therapeutic options, this guide also reviews the wide array of clinical studies on lung protection strategies and approaches to ARDS patients at ...

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Overview

This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Considering many emerging therapeutic options, this guide also reviews the wide array of clinical studies on lung protection strategies and approaches to ARDS patients at risk for VILI.

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Editorial Reviews

Doody's Review Service
Reviewer: David J. Dries, MD (University of Minnesota Medical School)
Description: This comprehensive review of an important clinical topic is a volume in the Lung Biology in Health and Disease series.
Purpose: Basic research, clinical consequences, and ongoing questions in ventilator-induced lung injury are presented.
Audience: Fellows and senior practitioners in multidisciplinary critical care medicine are an appropriate audience for this work. Editors and authors represent an international group providing seminal contributions to the understanding of this problem.
Features: Initial chapters include reviews of mechanical stress and hemodynamic and microcirculatory changes in the ventilated lung. These chapters set the stage for a review of mediators and mechanical/biological signal transduction and a discussion of the role for these factors in ventilator-induced lung injury. After cytokines and genomic aspects are reviewed, recent clinical trials and their implications for bedside management are discussed. Concluding chapters offer reviews of high frequency ventilation, clinical trial design, and imaging as a means to better understand interaction of the ventilator and lung. The 28 chapters are clearly written line drawings and black-and-white photographs reproduce with good quality. Each review contains an extensive reference list with emphasis on primary work dating to within two to three years of publication. The table of contents includes chapters, authorship, and major subheadings while a subject index of approximately 20 pages provides adequate access to content.
Assessment: The recent expansion in our understanding of ventilator-induced lung injury is one of the most important recent developments in cardiopulmonary critical care. This book reviews not only the exciting clinical developments in this area, it also provides an excellent overview of the physiology and molecular biology of this problem. The list of authors is a "who's who" of contributors in this area.
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Product Details

Table of Contents

INTRODUCTION. Ventilator-Induced Lung Injury: From Bench to Bedside and Back Again. ACUTE MANIFESTATIONS OF VILI. Pathological Features of ARDS and VILI. Imaging Alveolar Mechanics During VILI. Response of Cellular Plasma Membrane to Mechanical Stress. Passive and Active Changes in Microcascular Permeability During Lung Distension. Meodynamic Interactions During VILI. Gene Expression During VILI. Lung Mechanics and VILI. Effects of Acute Lung Distension on the Cytokine Network. SUBACUTE VILI. Inflammation Cascade During VILI. Apoptosis in the Lung and Remote Organs During VILI. Systemic Consequences of VILI/Evidence for Organ Failure Causation. Interaction of VILI with Previous Lung Alterations. Modulation of Lung Injury by Hypercapnia. Potential Implications of Genomics in the Prevention and Treatment of VILI. CLINICAL IMPLICATIONS OF VILI. Lung Imaging of Ventilator-Associated Injury. The Future of Lung Imaging of VILI/VALI. Modulation of the Cytokine Network by Lung Protective Mechanical Ventilation Strategies. Role of Tidal Volume and of Peep in the Reduction of Ventilator-Associated Lung Injury. A Critical Review of Randomized Controls of Tidal Volume Reduction During ARDS. PREVENTION AND TREATMENT OF VILI. The Importance of Protocol-Directed Management for Research on Lung Protective Ventilation. How to Design Clinical Studies for the Prevention of Ventilator-Associated Lung Injury? Potential Benefits and Risks of Partial Liquid Ventilation During Acute Lung Injury. Prospects for Reduction of VILI with Surfactant. Rationale for HFO Ventilations in Acute Lung Injury

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