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Doody's Review ServiceReviewer: David J. Dries, MD (University of Minnesota Medical School)
Description: This comprehensive review of an important clinical topic is a volume in the Lung Biology in Health and Disease series.
Purpose: Basic research, clinical consequences, and ongoing questions in ventilator-induced lung injury are presented.
Audience: Fellows and senior practitioners in multidisciplinary critical care medicine are an appropriate audience for this work. Editors and authors represent an international group providing seminal contributions to the understanding of this problem.
Features: Initial chapters include reviews of mechanical stress and hemodynamic and microcirculatory changes in the ventilated lung. These chapters set the stage for a review of mediators and mechanical/biological signal transduction and a discussion of the role for these factors in ventilator-induced lung injury. After cytokines and genomic aspects are reviewed, recent clinical trials and their implications for bedside management are discussed. Concluding chapters offer reviews of high frequency ventilation, clinical trial design, and imaging as a means to better understand interaction of the ventilator and lung. The 28 chapters are clearly written line drawings and black-and-white photographs reproduce with good quality. Each review contains an extensive reference list with emphasis on primary work dating to within two to three years of publication. The table of contents includes chapters, authorship, and major subheadings while a subject index of approximately 20 pages provides adequate access to content.
Assessment: The recent expansion in our understanding of ventilator-induced lung injury is one of the most important recent developments in cardiopulmonary critical care. This book reviews not only the exciting clinical developments in this area, it also provides an excellent overview of the physiology and molecular biology of this problem. The list of authors is a "who's who" of contributors in this area.