Virulence Mechanisms of Bacterial Pathogens

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Editorial Reviews

Eric R. Vimr
This is a collection of invited review articles drawn from presenters at the International Symposium on Virulence Mechanisms of Bacterial Pathogens. This edition contains reviews ranging from bacterial adherence and internalization to host strategies for overcoming bacterial virulence mechanisms. Many of the chapters are authored by recognized authorities in their specialties. The purpose is to provide researchers in the field of bacterial pathogenesis with reviews covering a range of molecular mechanisms relating to the disease process. Because this field continues to rapidly expand, well-written articles on the molecular biology of pathogen-host interactions are important in the training of graduate students and continuing education of senior researchers wishing to enter the field and those wanting to stay current in this subject. This volume is a second edition, but it covers different topics from the one published after the 1988 meeting. The current edition generally meets the editors' objective of publishing wide ranging reviews that are not located elsewhere. However, this book does not cover every or even the most important subjects in bacterial pathogenesis, but it is unlikely that any single volume could. There are other books available covering some of the neglected areas. However, I was disappointed by the lack of in-depth reviews on polysaccharide virulence factors, especially when compared to the overemphasis of iron-acquisition mechanisms. The book is assembled well and follows some form of linearity moving from bacterial colonization to survival to host strategies for countering pathogens. The figures and tables are in black-and-white. An excellent index can befound in back. Because this was meant as a companion to the first edition, it is too bad it did not include a table of contents and index to that previous edition. The book is reasonably priced, but it might best be used as a vehicle for entry into the primary literature. With a few exceptions, the articles are not sufficiently in depth to warrant individuals purchasing this volume, although every library should own a copy.
From The Critics
Reviewer: Eric R. Vimr, PhD (University of Illinois College of Veterinary Medicine)
Description: This is a collection of invited review articles drawn from presenters at the International Symposium on Virulence Mechanisms of Bacterial Pathogens. This edition contains reviews ranging from bacterial adherence and internalization to host strategies for overcoming bacterial virulence mechanisms. Many of the chapters are authored by recognized authorities in their specialties.
Purpose: The purpose is to provide researchers in the field of bacterial pathogenesis with reviews covering a range of molecular mechanisms relating to the disease process.
Audience: Because this field continues to rapidly expand, well-written articles on the molecular biology of pathogen-host interactions are important in the training of graduate students and continuing education of senior researchers wishing to enter the field and those wanting to stay current in this subject.
Features: This volume is a second edition, but it covers different topics from the one published after the 1988 meeting. The current edition generally meets the editors' objective of publishing wide ranging reviews that are not located elsewhere. However, this book does not cover every or even the most important subjects in bacterial pathogenesis, but it is unlikely that any single volume could. There are other books available covering some of the neglected areas. However, I was disappointed by the lack of in-depth reviews on polysaccharide virulence factors, especially when compared to the overemphasis of iron-acquisition mechanisms.
Assessment: The book is assembled well and follows some form of linearity moving from bacterial colonization to survival to host strategies for countering pathogens. The figures and tables are in black-and-white. An excellent index can be found in back. Because this was meant as a companion to the first edition, it is too bad it did not include a table of contents and index to that previous edition. The book is reasonably priced, but it might best be used as a vehicle for entry into the primary literature. With a few exceptions, the articles are not sufficiently in depth to warrant individuals purchasing this volume, although every library should own a copy.
Booknews
An overview of current knowledge of how bacterial pathogens do their dirty work, with sections on bacterial adherence, colonization, and invasion on mucosal surfaces; adaptation to extracellular environments; resistance to cellular defense mechanisms; bacterial toxins in disease production; and strategies to overcome bacterial virulence mechanisms. Emphasizes the mechanisms of host/pathogen interactions, rather than current research results and approaches. Of interest to molecular biologists, and researchers, students, and industrial scientists working with bacterial pathogens. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780914826996
  • Publisher: ASM Press
  • Publication date: 6/1/1988
  • Pages: 390

Table of Contents

Organizing Committee
Authors
Preface
Acknowledgments
1 Attachment and Interaction of Bacteria at Respiratory Mucosal Surfaces 3
2 Paradigms in Bacterial Entry into Host Cells 21
3 Mechanisms of Mucosal Colonization and Penetration by Bacterial Pathogens 33
4 Resistance of Bacteria to Complement 49
5 Quorum Sensing and Virulence Gene Regulation in Pseudomonas aeruginosa 65
6 Acquisition of Iron and Other Nutrients In Vivo 79
7 Role of Mycobacterial Constituents in Regulation of Macrophage Effector Function 99
8 Microbial Resistance to Macrophage Effector Functions: Strategies for Evading Microbicidal Mechanisms and Scavenging Nutrients within Mononuclear Phagocytes 115
9 Francisella tularensis, a Model Pathogen to Study the Interaction of Facultative Intracellular Bacteria with Phagocytic Host Cells 133
10 Bacterial Superantigens in Disease 145
11 Lipopolysaccharide and Bacterial Virulence 173
12 Phylogenetic Analyses of the RTX Toxin Family 195
13 Pore-Forming Toxins of Gram-Positive Bacteria 207
14 Bacterial ADP-Ribosylating Exotoxins 231
15 Ecological Concepts in the Control of Pathogens 245
16 Enhancement of Nonspecific Resistance to Bacterial Infection by Biological Response Modifiers 257
17 Vaccination Strategies for Mucosal Pathogens 269
18 Induction of Cytokine Formation by Bacteria and Their Products 303
19 The State and Future of Studies on Bacterial Pathogenicity 335
Index 359
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