Viruses and Human Disease

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Overview

This is the first text to examine the connection between virology and human disease. It is also the first book to integrate basic virology with pathophysiological conditions. By contrast, most virology textbooks focus on the molecular biology involved without adequate reference to physiology. Viruses and Human Disease is four-color throughout and contains clearly labeled figures and tables.

Key Features
*Provides a concise overview of animal viruses, emphasizing those causing diseases in humans;
* Integrates discussion of molecular biology, epidemiology, and the history of human viruses;
* Presents treatment of prions, gene therapy, and vaccine development;
* Illustrated in color by an expert virologist;
* Includes world maps depicting the current distribution of existing and newly emerging viruses

Audience: Advanced undergraduate and graduate students in virology, molecular biology, and microbiology.

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Editorial Reviews

From The Critics
Reviewer: Gregg N Milligan, Ph.D.(The University of Texas Medical Branch)
Description: This book on viruses and human disease is an excellent textbook or supplement for a graduate or undergraduate level virology course. The subject is approached from a human disease point of view but ample descriptions of the basic virology and molecular biology of each virus are provided.
Purpose: The authors have written a virology textbook based on a compilation of lecture material from their own virology courses. This book represents a very focused approach to virology based on a human disease perspective. The authors have succeeded in creating a relevant, well written, and user-friendly textbook.
Audience: The book is intended for students at the undergraduate or graduate level. The authors are internationally recognized leaders in the field of molecular virology. This is a well written and informative book appropriate for students in the life sciences, reflecting the authors' years of experience and expertise in the field of virology.
Features: The book is logically organized into chapters based on viral genome type. Common features and properties of virus families are thoroughly discussed providing a good overview of related viruses in addition to unique information about specific viruses. It is very easy to locate information on any given virus. The book is extremely well written and the color figures and tables are well organized, informative, and easy to understand. This is an excellent source of general information about all human viral pathogens.
Assessment: This book is exceptionally easy to read and full of "need-to-know" material appropriate for students. I found it to be well organized and thoughtfully prepared.
From The Critics
Reviewer: Gregg N Milligan, Ph.D.(The University of Texas Medical Branch)
Description: This book on viruses and human disease is an excellent textbook or supplement for a graduate or undergraduate level virology course. The subject is approached from a human disease point of view but ample descriptions of the basic virology and molecular biology of each virus are provided.
Purpose: The authors have written a virology textbook based on a compilation of lecture material from their own virology courses. This book represents a very focused approach to virology based on a human disease perspective. The authors have succeeded in creating a relevant, well written, and user-friendly textbook.
Audience: The book is intended for students at the undergraduate or graduate level. The authors are internationally recognized leaders in the field of molecular virology. This is a well written and informative book appropriate for students in the life sciences, reflecting the authors' years of experience and expertise in the field of virology.
Features: The book is logically organized into chapters based on viral genome type. Common features and properties of virus families are thoroughly discussed providing a good overview of related viruses in addition to unique information about specific viruses. It is very easy to locate information on any given virus. The book is extremely well written and the color figures and tables are well organized, informative, and easy to understand. This is an excellent source of general information about all human viral pathogens.
Assessment: This book is exceptionally easy to read and full of "need-to-know" material appropriate for students. I found it to be well organized and thoughtfully prepared.
Library Journal

A timely expansion of the original 2001 edition, which is based on course notes from James Strauss (Ethel Wilson Bowles & Robert Bowles Professor of Biology, emeritus, California Inst. of Technology), this book includes new, highly detailed examinations of internationally emergent viruses, including America's West Nile and Southeast Asia's Nipah viruses. In addition to geographical distribution maps and full-color illustrative charts, this edition considers viruses' possible role in triggering human pathology. A fascinating exploration of gene therapies and vaccination development concludes the book. Intended for the field specialist, this guide is an excellent complement to S.J. Flint and others' Principles of Virology. Recommended for medical collections in academic libraries.


—Staff
From The Critics
A textbook focusing on viruses as agents of human disease, but also considering essential information about their biology, epidemiology, and pathology; the molecular biology of their reproduction; and the diseases they cause. No more than basic biology is assumed. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
PRAISE FOR THE PREVIOUS EDITION:
"..exceptionally easy to read and full of 'need-to know' material appropriate for students. ...well organized and thoughtfully prepared."
—DOODY'S

3 Stars from Doody
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Product Details

  • ISBN-13: 9780126730500
  • Publisher: Elsevier Science
  • Publication date: 2/14/2002
  • Edition description: Older Edition
  • Pages: 383
  • Product dimensions: 8.74 (w) x 11.38 (h) x 0.85 (d)

Table of Contents

Preface
1 Overview of Viruses and Virus Infection
Classification of Viruses 5
An Overview of the Replication Cycle of Viruses 8
Effects of Virus Infection on the Host Cell 27
Epidemiology: The Spread of Viruses from Person to Person 29
2 The Structure of Viruses
Helical Symmetry 33
Icosahedral Symmetry 34
Nonenveloped Viruses with More Complicated Structural Features 43
Enveloped Viruses 43
Assembly of Virions 52
Stability of Virions 55
3 Plus-Strand RNA and Double-Strand RNA Viruses
Family Picornaviridae 58
Family Caliciviridae 71
Family Astroviridae 74
Family Togaviridae 76
Family Flaviviridae 85
Family Coronaviridae 100
Family Arteriviridae 103
The Plus-Strand RNA Viruses of Plants 104
Origin and Evolution of Plus-Strand RNA Viruses 105
Viruses That Contain Double-Stranded RNA: Family Reoviridae 108
4 Minus-Strand RNA Viruses
Overview of the Minus-Strand RNA Viruses 123
Family Rhabdoviridae 126
Family Paramyxoviridae 132
Family Filoviridae 144
Family Bornaviridae 146
Family Orthomyxoviridae 147
Family Bunyaviridae 156
Family Arenaviridae 162
Evolution of Minus-Strand RNA Viruses 168
5 Viruses Whose Life Cycle Uses Reverse Transcriptase
Family Retroviridae 172
Family Hepadnaviridae 210
6 DNA-Containing Viruses
Family Poxviridae 223
Family Herpesviridae 234
Family Adenoviridae 252
Family Polyomaviridae 259
Family Papillomaviridae 265
Family Parvoviridae 270
TT Virus: A Newly Described Human Virus 276
7 Subviral Agents
Defective Interfering Viruses 279
Satellites and Satellite Viruses 283
Viroids and Virusoids 284
Hepatitis [sigma] 284
Prions and Prion Diseases 291
8 Host Defenses against Viral Infection and Viral Counterdefenses
Adaptive Immune System 303
Innate Immune System 323
Viral Counterdefenses 334
Interactions of Viruses with Their Hosts 345
9 Gene Therapy
Virus Vector Systems 347
Use of Viruses as Expression Vectors 357
App. A: References for Figures 367
App. B: References for Tables 373
Index 375
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