Vitamin D: Physiology, Molecular Biology, and Clinical Applications / Edition 2

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Overview

In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus.

The first edition of Vitamin D: Physiology, Molecular Biology and Clinical Applications was the benchmark in the field when published in 1999. This new and expanded volume continues to include extensive, in-depth chapters covering the most important aspects of the complex interactions between vitamin D and other dietary components, the ongoing debate concerning the best indicator of optimal vitamin D status and its nutrient requirements, and the impact of less than optimal status on disease risk. Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.

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Editorial Reviews

Doody Reviews
Reviewer: Heather Huang, MD (Rush University Medical Center)
Description: This comprehensive book covers everything that is currently known about Vitamin D. It discusses topics ranging from the molecular biology of vitamin D and its role in human physiology to its role in health and disease.
Purpose: The purpose was to develop a standard book on vitamin D that also educates people about the prevalence and significance of vitamin D deficiency.
Audience: This book is so comprehensive that an extremely wide audience would find it useful: graduate students, medical students, healthcare professionals, nutritionists, and the lay public.
Features: The first 11 chapters cover the basics of vitamin D biology (photobiology, molecular biology, metabolism, biologic affects on various organ systems, and genetic effects). The second section focuses on the nonskeletal functions of vitamin D, while the third comprehensively reviews vitamin D, its role in diseases, and its epidemiology in countries across the globe. Health consequences of a vitamin D deficiency are the focus of the fourth section, while the fifth examines the interactions between sunlight, vitamin D, and cancer. The final two sections look at the clinical importance of vitamin D in its natural and synthetic form in multiple diseases: type 1 and 2 diabetes, cardiovascular health, lung diseases, chronic immune-related diseases, and cancer.
Assessment: The current scientific literature about vitamin D is eloquently summarized in this book. Topics range from molecular biology, clinical physiology and pathophysiology, to epidemiology, treatment, and disease prevention. The book reads consistently and easily from cover to cover, making it accessible to both scientists and nonscientists. The comprehensive care and attention to detail that went into each chapter clearly conveys the passion that the editor has for this subject.
Doody's Review Service
Reviewer: Heather Huang, MD (University of Wisconsin School of Medicine and Public Health)
Description: This comprehensive book covers everything that is currently known about Vitamin D. It discusses topics ranging from the molecular biology of vitamin D and its role in human physiology to its role in health and disease.
Purpose: The purpose was to develop a standard book on vitamin D that also educates people about the prevalence and significance of vitamin D deficiency.
Audience: This book is so comprehensive that an extremely wide audience would find it useful: graduate students, medical students, healthcare professionals, nutritionists, and the lay public.
Features: The first 11 chapters cover the basics of vitamin D biology (photobiology, molecular biology, metabolism, biologic affects on various organ systems, and genetic effects). The second section focuses on the nonskeletal functions of vitamin D, while the third comprehensively reviews vitamin D, its role in diseases, and its epidemiology in countries across the globe. Health consequences of a vitamin D deficiency are the focus of the fourth section, while the fifth examines the interactions between sunlight, vitamin D, and cancer. The final two sections look at the clinical importance of vitamin D in its natural and synthetic form in multiple diseases: type 1 and 2 diabetes, cardiovascular health, lung diseases, chronic immune-related diseases, and cancer.
Assessment: The current scientific literature about vitamin D is eloquently summarized in this book. Topics range from molecular biology, clinical physiology and pathophysiology, to epidemiology, treatment, and disease prevention. The book reads consistently and easily from cover to cover, making it accessible to both scientists and nonscientists. The comprehensive care and attention to detail that went into each chapter clearly conveys the passion that the editor has for this subject.
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Product Details

  • ISBN-13: 9781603273008
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/23/2010
  • Series: Nutrition and Health Series
  • Edition description: 2nd ed. 2010
  • Edition number: 2
  • Pages: 1160
  • Product dimensions: 7.10 (w) x 10.00 (h) x 2.00 (d)

Table of Contents

Dedication to Louis V. Avioli Steve Teitelbaum
A. Introduction and Basic Biology
1. Vitamin D and Health: Evolution, Biologic Functions, and Dietary Requirements for Vitamin D Michael F. Holick
2. Photobiology of Vitamin D Tai C. Chen, Zhiren Lu and Michael F. Holick
3. The Functional Metabolism and Molecular Biology of Vitamin D Action Lori A. Plum and Hector F. DeLuca
4. Metabolism and Catabolism of Vitam D, its Metabolites and Clinically Relevant Analogs Glenville Jones
5. The Molecular Biology of the Vitamin D Receptor Diane R. Dowd and Paul N. MacDonald
6. VDR and RXR Subcellular Trafficking Julia Barsony
7. Mechanism of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport Dare Ajibade, Bryan S. Benn and Sylvia Christakos
8. Biologic and Molecular Effects of Vitamin D on Bone Martin A. Montecino, Jane B. Lian, Janet L. Stein, Gary S. Stein, Andre J. van Wijnen, Fernando Cruzat
9. Biologic and Molecular Effect of Vitamin D on the Kidney Adriana S. Dusso and Masanori Tokumoto
10. Vitamin D and the Parathyroids Justin Silver and Tally Naveh Many
11. Diversity of Vitamin D Target Genes Carsten Carlberg
B. Non-skeletal/Functions of Vitamin D
12. Extra Renal Synthesis of 1,25-Dihydroxyvitamin D and Health Implications Daniel D. Bikle
13. Vitamin D and the Innate Immunity Philip Liu, Martin Hewison, John S. Adams
14. Vitamin D and Colon Cancer Heidi S. Cross and Meinrad Peterlik
15. Mechanisms of Resistance to Vitamin D action in Human Cancer Cells Maria Jesus Iarriba and Alberto Munoz
16. Vitamin D and the Brain: A Neuropsychiatric Perspective Louise Harvey, Thomas Burne, Xiaoying Cui, Alan Mackay-Sim, Darryl Eyles and John McGrath
17. Vitamin D Modulation of Adipocyte Function Michael B. Zemel and Xiaocun Sun
C. Vitamin D Status - Global Analysis
18. Determinants of Vitamin D Intake and Vitamin D Deficiency in the United States Mona S. Calvo and Susan J. Whiting
19. 25-hydroxyvitamin D Assays and Their Clinical Utility Neil C. Binkley and Gary Leusmeyer
20. Health Disparity and Vitamin D Deficiency in the United States Douglass Bibuld
21. Vitamin D Deficiency and its Health Consequences in Canada David A. Hanley
22. Vitamin D Deficiency and its Health Consequences in Northern Europe Leif Mosekilde
23. Vitamin D Deficiency and its Health Consequences in Mediterranean Countries Jose Manuel Quesada Gomez and Manuel Diaz-Curiel
24. Vitamin D Deficiency in the Middle East and its Health Consequences for Children Ghada El-Hajj Fuleihan
25. Vitamin D Deficiency in the Middle East and its Health Consequences for Adults El-Kaissi Samer and Suphia Sherbeeni
26. Vitamin D Deficiency and its Health Consequences in Africa Ann Prentice, Inez Schoenmakers, Kerry Jones, Landing Jarjou, Gail Goldberg
27. Vitamin D Deficiency and its Health Consequences in India R.K. Marwaha and R. Goswami
28. Vitamin D Deficiency, Rickets and Flourosis in India CV Harinaragan, CV and Shashank R Joshi
29. Vitamin D Deficiency and its Health Consequences in Asia Tim Green and Bernard Venn
30. Vitamin D Deficiency and its Health Consequences in New Zealand Mark J. Boland Ian R. Reid
31. Toxicity of Vitamin D Reinhold Vieth
D. Health Consequences of Vitamin D Deficiency and Resistance on Musculoskeletal Health
32. Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences Sarah N. Taylor, Carol L. Wagner, Bruce Hollis
33. Vitamin D Def

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