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Vitamin D: Physiology, Molecular Biology and Clinical Applications / Edition 1

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Overview

A comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus. Vitamin D: Physiology, Molecular Biology, and Clinical Applications will serve as an authoritative day-to-day source for all those health care professionals, internists, dermatologists, house staff, and basic scientists who seek today's clearest understanding of the broad role of vitamin D in human health.

The book contains black-and-white illustrations.

This book is of particular interest to biochemists, physiologists, molecular and cell biologists, and nutritionists.

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Editorial Reviews

Doody's Review Service
Reviewer: Ada A. Cole, PhD (Rush Medical College of Rush University)
Description: This is the first of the Nutrition and Health series intended to highlight the status of science in a particular field. The task given to the editor for this series was to recruit authors for individual chapters who were capable of assembling and interpreting the area for those health professionals for whom the book was intended. In this book, the task has been admirably accomplished with internationally respected authors covering 25 individual chapters, including historical perspective, basic science, and clinical science.
Purpose: The purpose is to educate students as well as professionals on the broad spectrum of activities of vitamin D and its importance to human health. In addition, this is a reference source for the use of vitamin D in the continuing maintenance of a healthy body as we continue to age.
Audience: This book is intended for anyone in the field of healthcare, students as well as teachers, who are interested in the metabolism of vitamin D and its effect on normal homeostasis.
Features: This book covers photobiology, vitamin D metabolites and receptors, as well as regulation of the vitamin. It is well organized with an extensive, current bibliography and excellent diagrams, some of which are in color.
Assessment: This book will be a useful reference for anyone in the healthcare field. The chapters are focused on individual topics to provide the broadest information. This book would be a valuable addition to many libraries, both individual as well as academic.
Ada A. Cole
This is the first of the Nutrition and Health series intended to highlight the status of science in a particular field. The task given to the editor for this series was to recruit authors for individual chapters who were capable of assembling and interpreting the area for those health professionals for whom the book was intended. In this book, the task has been admirably accomplished with internationally respected authors covering 25 individual chapters, including historical perspective, basic science, and clinical science. The purpose is to educate students as well as professionals on the broad spectrum of activities of vitamin D and its importance to human health. In addition, this is a reference source for the use of vitamin D in the continuing maintenance of a healthy body as we continue to age. This book is intended for anyone in the field of healthcare, students as well as teachers, who are interested in the metabolism of vitamin D and its effect on normal homeostasis. This book covers photobiology, vitamin D metabolites and receptors, as well as regulation of the vitamin. It is well organized with an extensive, current bibliography and excellent diagrams, some of which are in color. This book will be a useful reference for anyone in the healthcare field. The chapters are focused on individual topics to provide the broadest information. This book would be a valuable addition to many libraries, both individual as well as academic.
Booknews
A broad reference for internists, dermatologists, house staff, basic scientists, and other health-care professionals interested in the role of vitamin D in human health. Ranges through such topics as recent recommendations for intake; new approaches for treating and preventing deficiency; vitamin D drugs for psoriasis and cancer; the relationship between sunlight exposure, vitamin D, and the increased risk of colon and breast cancer; how vitamin D is made in the skin and the sequence of events that leads to activation in the kidney; the biological functions of 1,25-dihydrovitamin D3 on the intestine, bone, skin, immune system, prostate, and breast; and the vitamin's molecular mechanism on the cell membrane and nucleus. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780896034679
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/28/1998
  • Series: Nutrition and Health Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 458
  • Product dimensions: 7.20 (w) x 10.10 (h) x 1.10 (d)

Table of Contents

In Memoriam: John G. Haddad
Series Introduction
Preface
Contributors
1 Evolution, Biologic Functions, and Recommended Dietary Allowances for Vitamin D 1
2 Photobiology of Vitamin D 17
3 Functional Metabolism and Molecular Biology of Vitamin D Action 39
4 Metabolism and Catabolism of Vitamin D, Its Metabolites, and Clinically Relevant Analogs 57
5 The Enzymes Responsible for Metabolizing Vitamin D 85
6 The Vitamin D Binding Protein and Its Clinical Significance 101
7 Molecular Biology of the Vitamin D Receptor 109
8 Vitamin D Receptor Translocation 129
9 Molecular Recognition and Structure-Activity Relations in Vitamin D-Binding Protein and Vitamin D Receptor 147
10 Mechanism of Action of 1,25-Dihydroxyvitamin D[subscript 3] on Intestinal Calcium Absorption and Renal Calcium Transport 163
11 Biologic and Molecular Effects of Vitamin D on Bone 175
12 Nongenomic Rapid Effects of Vitamin D 195
13 Noncalcemic Actions of 1,25-Dihydroxyvitamin D[subscript 3] and Clinical Implications 207
14 Regulation of Parathyroid Hormone Gene Expression and Secretion by Vitamin D 217
15 Vitamin D Assays and Their Clinical Utility 239
16 Rickets and Vitamin D Deficiency 273
17 Vitamin D and Bone Health in Adults and the Elderly 287
18 Inherited Defects of Vitamin D Metabolism 307
19 Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets 317
20 Extrarenal Production of 1,25-Dihydroxyvitamin D and Clinical Implications 337
21 Clinical Utility of 1,25-Dihydroxyvitamin D[subscript 3] and Its Analogs for the Treatment of Psoriasis and Other Skin Diseases 357
22 Epidemiology of Cancer Risk and Vitamin D 375
23 Chemotherapeutic and Chemopreventive Actions of Vitamin D[subscript 3] Metabolites and Analogs 393
24 Vitamin D and Breast Cancer 411
25 Anticancer Activity of Vitamin D Analogs 431
Index 447
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