What the Doctor Didn't Say: The Hidden Truth about Medical Research

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Overview

Millions of people each year decide to participate in clinical trials—medical research studies involving an innovative treatment for a medical problem. For the patient, such participation can sometimes be a life-saving choice. But it can also be just the opposite. Our country years ago adopted rules designed to assure that people are making informed choices about participation. This book explains the reality behind those rules: that our current system of clinical trials hides much of the information patients need to make the right choices.

Witness the following scenarios:

-Hundreds of patients with colon cancer undergo a new form of keyhole surgery at leading cancer centers—never being told that 85% of colorectal surgeons, worried that it increases the risk of the cancer returning, would not themselves undergo that procedure.

-Tens of thousands of women at high risk of developing breast cancer are asked to participate in a major research study. They are told about the option of having both breasts surgically removed—but not told about the option of taking a standard osteoporosis pill that might cut the risk of getting breast cancer by one-half or more.

What The Doctor Didn't Say, principally written by a nationally prominent expert, is the first book to reveal many heretofore hidden aspects about the true nature of participation in clinical trials. It shows why options not commonly known—including getting a new treatment outside of a research study—can often be the best choice. It explains how patients can make good decisions even if there is only limited information about a treatment's effect. And it does this through the eye-opening stories of what is happening daily to thousands of people.

This book ends up confronting the fundamental dilemma of medical research: Participation in clinical trials plays a vital role in advancing knowledge, and many experts fear that if the information provided herein became widely known, fewer people would participate. But the authors demonstrate that there is no need to deceive people into participating in research. We can have a system that promotes participation while still providing truthful information to participants.

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Editorial Reviews

From the Publisher
"Take my advice: study carefully this deftly written account of the hackneyed myths and jarring realities of human subjects experimentation."—Jerome P. Kassirer, M.D., Distinguished Professor, Tufts University School of Medicine, Editor-in-Chief Emeritus, New England Journal of Medicine

"A very good book, precisely because it is so disturbing. All of us tend to think that medical research will continue to progress in linear fashion. Yet as Jerry Menikoff's comprehensive and insightful book reveals, many hidden obstacles lie along the path to medical improvements. Most patients enroll in clinical trials because they are desperately ill, and rightly concerned with their own health and welfare. Menikoff highlights the genuine conflicts of interest between care for the patient and the advancement of science that cannot, and should not, be swept under the rug."—Richard A. Epstein, James Parker Hall Distinguished Service Professor of Law, University of Chicago

"Finally! A book for the layperson that explodes the myths, unpacks the mysteries and tells the truth about medical research. It should be required reading for anyone thinking of entering a clinical trial. Menikoff has done the public a great service."—Mary Faith Marshall, Ph.D., Professor, Center for Bioethics and Associate Dean, University of Minnesota Medical School

"What the Doctor Didn't Say combines depth of scholarship and clear writing with wisdom, experience and sound judgment to create a volume that is essential for understanding the rights and interests of patients and the obligations of providers in the dance of medicine called informed consent. It provides the gold standard of understanding that should be the starting point for discussion and future research."—Nancy Neveloff Dubler, Director, Division of Bioethics, Montefiore Medical Center, and Professor of Epidemiology and Population Health, Albert Einstein College of Medicine

"Menikoff's book tells us that if we believe in the research enterprise, then we must accept that persons, consenting and not consenting, will be exposed to risks—sometimes very substantial risks."—New England Journal of Medicine

"This is most definitely a book not to be sneered at; an interesting insight into a mystical sphere of clinical research."—London Medical Student Journal

"His observations regarding clinical trials in the way they are typically conducted are striking...Insightful and sometimes painfully honest book."—The Journal of Legal Medicine

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Product Details

  • ISBN-13: 9780195147971
  • Publisher: Oxford University Press, USA
  • Publication date: 8/7/2006
  • Edition description: 1ST
  • Pages: 336
  • Sales rank: 1,402,895
  • Product dimensions: 9.30 (w) x 6.30 (h) x 0.80 (d)

Meet the Author

Jerry Menikoff is Associate Professor of Law, Ethics & Medicine at the University of Kansas School of Medicine, where he is also Director of the Institute for Bioethics, Law & Public Policy and chair of the Human Subjects Committee. He is also Associate Professor of Law at the University of Kansas School of Law. He is the author of a leading textbook on law and bioethics and co-author of a textbook on the ethics and regulation of research with human subjects. He has on a number of occasions served as a consultant to the federal government on issues relating to protecting research subjects.

Edward P. Richards is Harvey A. Peltier Professor of Law at the Louisiana State University, where he directs the program in Law, Science, and Public Health. He has published several books and more than 100 articles on health and public health policy, and has consulted with state and federal agencies on public health and policy. He worked in medical research before becoming a law professor and has taught both FDA and biotechnology law.

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Table of Contents

1. The Dilemma of Human Research
Part I: How Good Studies Can Be Bad Choices
2. The Nature of Research
3. A Case Study: The Difference Between Being a Patient and Being a Research Subject
4. How the Law Protects Patients Who Get Non-Standard Care
5. The Weakened Legal Protections Given to Research Subjects
6. How Bad for the Subjects Can the Study Be?
Part II: Consent: What Are Subjects Told?
7. What Informed Consent Requires
8. The Anatomy of a Consent Form
9. The Good, the Bad, and the Ugly Research Study: From Consent to Choice
10. The Hidden Alternative
Part III: When Consent Can't Be Obtained
11. Incompetent Adults
12. Emergency Research
13. Children in Research: The Basic Rules
14. Can Children Be Enrolled in Studies That Are Bad for Them?
15. Research and Reproduction
Part IV: The Role of Money
16. Should Research Subjects be Paid?
17. Compensating Researchers: Dealing with Conflicts of Interest
Part V: The Challenge for the Future
18. Where Do We Go From Here: The Paradox of Pediatric Oncology Research
Index

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