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Williams Hematology, Eighth Edition / Edition 8

Williams Hematology, Eighth Edition / Edition 8

by Kenneth Kaushansky, Uri Seligsohn, Marshall Lichtman, Thomas Kipps, Josef Prchal

ISBN-10: 0071621512

ISBN-13: 9780071621519

Pub. Date: 07/09/2010

Publisher: McGraw-Hill Professional Publishing

The landmark hematology reference — now in full color

A Doody's Core Title for 2015!

"This edition continues the tradition of providing a comprehensive, updated textbook of hematology. This very worthy objective is spectacularly met by this edition. As a textbook of hematology, this has a broad-based audience — medical


The landmark hematology reference — now in full color

A Doody's Core Title for 2015!

"This edition continues the tradition of providing a comprehensive, updated textbook of hematology. This very worthy objective is spectacularly met by this edition. As a textbook of hematology, this has a broad-based audience — medical students, residents, fellows, and practitioners (including our allied healthpartners) in virtually every aspect of medicine. The authors and editors are internationally recognized — in fact, luminaries, in their fields....Williams continues to sustain its unparalleled reputation as THE textbook of hematology. I've run out of superlatives. Get it."—Doody's Review Service

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. The book begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Featuring a brand-new full-color presentation, the Eighth Edition of Williams Hematology is extensively revised to reflect the latest views of experts in the field. Two new chapters examine the importance of genomics in hematology and cell therapy for tissue replacement, whereas other chapters have been revised to incorporate the newest clinical approaches to the leukemias and lymphomas, and the application of targeted therapy in the treatment of hematologic disorders.

New to this Edition:

  • Full-color presentation conveniently integrates images of blood and tissue findings where they are cited in the text
  • Two additional chapters, “Genomics and Epigenetics,” and “Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement,” offer insights into the application of genomic and monoclonal therapies to hematology and emphasize their role in improving diagnostic and therapeutic methods
  • Expanded coverage of non-Hodgkin lymphoma includes separate chapters on its constituent diseases, providing an in-depth assessment of the diagnosis and management of these disorders
  • A comprehensive discussion of erythrocytosis and thrombocytosis reviews reactive and malignant forms of myeloproliferation, encompassing new genetic advances in these disorders along with more targeted therapeutic approaches
  • Companion CD includes a large selection of morphologies, illustrations, and drawings from the book, in a presentation-ready PowerPoint format

Product Details

McGraw-Hill Professional Publishing
Publication date:
Edition description:
Older Edition
Product dimensions:
9.00(w) x 10.90(h) x 3.00(d)

Related Subjects

Table of Contents




1. Initial Approach to the Patient: History and Physical Examination, Marshal A. Lichtman and Ernest Beutler

2. Examination of Blood Cells, Daniel H. Ryan

3. Examination of the Marrow, Daniel H. Ryan


4. Structure of the Marrow and the Hematopoietic Microenvironment, Mark J. Koury and Marshall A. Lichtman

5. The Organization and Structure of Lymphoid Tissues, Thomas J. Kipps


6. Hematology of the Fetus and Newborn, James Palis and George B. Segel

7. Hematology during Pregnancy, Martha P. Mims and Josef T. Prchal

8. Hematology in Older Persons, William B. Ershler and Dan L. Longo


9. Genetic Principles and Molecular Biology, Ernest Beutler

10. Genomics and Epigenetics, Lynn B. Jorde

11. Cytogenetics and Molecular Abnormalities, Lucy A. Godley and Michelle M. Le Beau

12. Apoptosis, Roberta A. Gottlieb

13. Cell-Cycle Regulation and Hematologic Disorders, Mathias Schmid and Dennis A. Carson

14. Signal Transduction Pathways, Kenneth Kaushansky

15. The Cluster of Differentiation Antigens, Thomas J. Kipps

16. Hematopoietic Stem Cells, Progenitors, and Cytokines, Kenneth Kaushansky

17. The Inflammatory Process, Jeffrey S. Warren and Peter A. Ward

18. Innate Immunity, Bruce Beutler

19. Dendritic Cells and the Control of Innate Adaptive Immunity, Madhav Dhodapkar and Ralph M. Steinman


20. Pharmacology and Toxicity of Antineoplastic Drugs, Bruce A. Chabner, Jeffrey Barnes, James Cleary, Andrew Lane, Constantine Mitsiades, and Paul Richardson

21. Principles of Hematopoietic Cell Transplantation, Robert Lowsky and Robert S. Negrin

22. Treatment of Infections in the Immunocompromised Host, Steven Beutler and Lisa Beutler

23. Principles of Antithrombotic Therapy, Charles W. Francis and Mark Crowther

24. Principles of Immune Cell Therapy, Carolina Berger and Stanley R. Riddell

25. Principles of Vaccine Therapy, Sattva S. Neelapu and Larry W. Kwak

26. Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications, Bruce C. McLeod

27. Principles of Gene Transfer for Therapy, Januario E. Castro and Thomas J. Kipps

28. Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement, Armand Keating


29. Morphology of the Erythron, Brian S. Bull and Paul C. Herrmann

30. Composition of the Erythrocyte, Ernest Beutler

31. Production of Erythrocytes, Josef T. Prchal

32. Destruction of Erythrocytes, Ernest Beutler

33. Clinical Manifestations and Classification of Erythrocyte Disorders, Josef T. Prchal

34. Aplastic Anemia: Acquired and Inherited, George B. Segel and Marshall A. Lichtman

35. Pure Red Cell Aplasia, Neal S. Young

36. Anemia of Chronic Renal Disease, Jaime Caro and Ubaldo Martinez Outschoorn

37. Anemia of Chronic Disease, Tomas Ganz

38. Anemia of Endocrine Disorders, Xylina T. Gregg and Josef T. Prchal

39. The Congenital Dyserythropoietic Anemias, Jean Delaunay

40. Paroxysmal Nocturnal Hemoglobinuria, Charles J. Parker

41. Folate, Cobalamin, and Megaloblastic Anemias, Ralph Green

42. Disorders of Iron Metabolism, Ernest Beutler

43. Anemia Resulting from Other Nutritional Deficiencies, Ralph Green

44. Anemia Associated with Marrow Infiltration, Archana M. Agarwal and Josef T. Prchal

45. The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseaes, Patrick G. Gallagher

46. Disorders of Red Cells Resulting from Enzyme Abnormalities, Wouter W. van Solinge and Richard van Wijk

47. The Thalassemias: Disorders of Globin Synthesis, David J. Weatherall

48. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities, Kavita Natarajan, Tim M. Townes, and Abdullah Kutlar

49. Methemoglobinemia and Other Dyshemoglobinemias, Neeraj Agarwal and Josef T. Prchal

50. Hemolytic Anemia Resulting from Physical Injury to Red Cells, Kelty R. Baker and Joel Moake

51.Hemolytic Anemia Resulting from Chemical and Physical Agents, Brian S. Bull and Paul C. Herrmann

52. Hemolytic Anemia Resulting from Infections with Microorganisms, Marshall A. Lichtman

53. Hemolytic Anemia Resulting from Immune Injury, Charles H. Packman

54. Alloimmune Hemolytic Disease of the Fetus and Newborn, Jayashree Ramasethu and Naomi L. C. Luban

55. Hypersplenism and Hyposlenism, Jaime Caro and Ubaldo Martinez Outschoorn

56. Primary and Secondary Polycythemias (Erythrocytosis), Josef T. Prchal

57. The Porphyrias, John D. Phillips and Karl E. Anderson

58. Hereditary and Acquired Sideroblastic Anemias, Prem Ponka and Josef T. Prchal


59. Morphology of Neutrophils, Eosinophils, and Basophils, C. Wayne Smith

60. Composition of Neutrophils, C. Wayne Smith

61. Production, Distribution, and Fate of Neutrophils, C. Wayne Smith

62. Eosinophils and Their Disorders, Andrew J. Wardlaw

63. Basophils and Mast Cells and Their Disorders, Stephen J. Galli, Dean D. Metcalfe, Daniel A. Arber, and Ann M. Dvorak

64. Classification and Clinical Manifestations of Neutrophil Disorders, Marshall A. Lichtman

65. Neutropenia and Neutrophilia, David C. Dale

66. Disorders of Neutrophil Function, Niels Borregaard and Laurence A. Boxer


67. Morphology of Monocytes and Macrophages, Steven D. Douglas and Florin Tuluc

68. Biochemistry and Functions of Monocytes and Macrophages, Annette Pluddemann and Siamon Gordon

69. Production, Distribution, and Fate of Monocytes and Macrophages, Siamon Gordon and Annette Pluddemann

70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages, Marshall A. Lichtman

71. Monocytosis and Monocytopenia, Marshall A. Lichtman

72. Inflammatory and Malignant Histiocytosis, Kenneth L. McClain and Carl E. Allen

73. Lipid Storage Diseases, Ari Zimran and Deborah Elstein


74. Morphology of Lymphocytes and Plasma Cells, H. Elizabeth Broome

75. Composition and Biochemistry of Lymphocytes and Plasma Cells, Thomas J. Kipps

76. Lymphopoiesis, Gay M. Crooks

77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production, Thomas J. Kipps

78. Functions of T Lymphocytes: T-Cell Receptors for Antigen, Thomas J. Kipps

79. Functions of Natural Killer Cells, Giorgio Trinchieri and Lewis L. Lanier

80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders, Thomas J. Kipps

81. Lymphocytosis and Lymphocytopenia, Thomas J. Kipps

82. Immunodeficiency Diseases, Hans D. Ochs and Luigi D. Notarangelo

83. Hematologic Manifestations of Acquired Immunodeficiency Syndrome, Erin Gourley Reid

84. Mononucleosis Syndromes, Robert F. Betts


85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders, Marshall A. Lichtman

86. Polycythemia Vera, Josef T. Prchal and Jaroslav F. Prchal

87. Essential Thrombocythemia, Philip A. Beer and Anthony R. Green

88. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia), Jane L. Liesveld and Marshall A. Lichtman

89. Acute Myelogenous Leukemia, Jane L. Liesveld and Marshall A. Lichtman

90. Chronic Myelogenous Leukemia and Related Disorders, Jane L. Liesveld and Marshall A. Lichtman

91. Primary Myelofibrosis, Marshall A. Lichtman and Ayalew Tefferi


92. Classification of Malignant Lymphoid Disorders, Thomas J. Kipps and Huan-You Wang

93. Acute Lymphoblastic Leukemia, Ching-Hon Pui

94. Chronic Lymphocytic Leukemia and Related Diseases, Thomas J. Kipps

95. Hairy Cell Leukemia, Darren Sigal and Alan Saven

96. Large Granular Lymphocytic Leukemia, Thomas P. Loughran and Marshall E. Kadin

97. General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodel Disease, Kenneth A. Foon and Marshall A. Lichtman

98. Pathology of Malignant Lymphomas, Randy D. Gascoyne and Kenneth A. Foon

99. Hodgkin Lymphoma, Sandra J. Horning

100. Diffuse Large B-Cell Lymphoma, Michael Boyiadzis and Kenneth A. Foon

101. Follicular Lymphoma, Oliver W. Press

102. Mantle Cell Lymphoma, Jorge E. Romaguera and Peter W. McLaughlin

103. Marginal Zone B-Cell Lymphomas, Emanuele Zucca

104. Burkitt Lymphoma, Jonathan W. Friedberg and Archibald S. Perkins

105. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome), Larisa J. Geskin

106. Mature T-Cell and Natural Killer Cell Lymphomas, Oscar B. Goodman, Jr. and Nam H. Dang

107. Plasma Cell Neoplasms: General Considerations, H. Elizabeth Broome

108. Essential Monoclonal Gammopathy, Marshall A. Lichtman

109. Myeloma, Frits van Rhee, Elias Anaissie, Edgardo Angtuaco, Twyla Bartel, Joshua Epstein, Bijay Nair, John Shaughnessy, Shmuel Yaccoby, and Bart Barlogie

110. The Amyloidoses, Vaishali Sanchorawala, Daniel R. Jacobson, David C. Seldin, and Joel N. Buxbaum

111. Macroglobulinemia, Steven P. Treon and Giampaolo Merlini

112. Heavy-Chain Disease, Dietlind L. Wahner-Roedler and Robert A. Kyle


113. Megakaryopoiesis and Thrombopoiesis, Kenneth Kaushansky

114. Platelet Morphology, Biochemistry, and Function, Susan S. Smyth, Sidney Whiteheart, Joseph E. Italiano, Jr. and Barry S. Coller

115. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostatis, Dougald M. Monroe, III, Maureane Hoffman, and Harold R. Roberts

116. Control of Coagulation Reactions, John H. Griffin

117. Vascular Function in Hemostatis, Katherine A. Hajjar, Aaron J. Marcus, and William Muller

118. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostatis, Uri Seligsohn and Kenneth Kaushansky

119. Thrombocytopenia, Reyhan Diz-Kucukkaya, Junmei Chen, Amy Geddis, and Jose A. Lopez

120. Reactive Thrombocytosis, Kenneth Kaushansky

121. Hereditary Qualitative Platelet Disorders, Barry S. Coller, Deborah L. French, and A. Koneti Rao

122. Acquired Qualitative Platelet Disorders, Charles S. Adams, Sanford J. Shattil, and Joel S. Bennett

123. The Vascular Purpuras, Doru T. Alexandrescu and Richard L. Gallo

124. Hemophilia A and Hemophilia B, Harold R. Roberts, Nigel S. Key, adn Miguel A. Escobar

125. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors, Uri Seligsohn, Ariella Zivelin, and Ophira Salomon

126. Hereditary Fibrinogen Abnormalities, Marguerite Neerman-Arbez and Philippe de Moerloose

127. Von Willebrand Disease, Jill Johnsen and David Ginsburg

128. Antibody-Mediated Coagulation Factor Deficiencies, Pete Lollar

129. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation, Ton Lisman and Philip G. De Groot

130. Disseminated Intravascular Coagulation, Marcel Levi and Uri Seligsohn

131. Hereditary Thrombophilia, Uri Seligsohn and Aharon Lubetsky

132. The Antiphospholipid Syndrome, Jacob H. Rand

133. Antibody-Mediated Thrombotic Disorders: Thrombotic-Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia, J. Evan Sadler and Mortimer Poncz

134. Venous Thrombosis, Gary E. Raskob, Russell D. Hull, and Graham F. Pineo

135. Atherothrombosis: Disease Initiation, Progression, and Treatment, Emile R. Mohler III and Andrew I. Schafer

136. Fibrinolysis and Thrombolysis, Katherine A. Hajjar and Jia Ruan


137. Erythrocyte Antigens and Antibodies, Marion E. Reid

138. Human Leukocyte and Platelet Antigens, Myra Coppage, David Stroncek, Janice McFarland, and Neil Blumberg

139. Blood Procurement and Screening, Jeffrey McCullough

140. Red Cell Transfusion, Norma B. Lerner, Majed A. Rafaai, and Neil Blumberg

141. Preservation and Clinical Use of Platelets, Mike Murphy and Ralph Vassallo


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