Williams Hematology, Eighth Edition / Edition 8

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The landmark hematology reference -- now in full color

A Doody's Core Title ESSENTIAL PURCHASE for 2011!


"This edition continues the tradition of providing a comprehensive, updated textbook of hematology. This very worthy objective is spectacularly met by this edition. As a textbook of hematology, this has a broad-based audience -- medical students, residents, fellows, and practitioners (including our allied health

partners) in virtually every aspect of medicine. The authors and editors are internationally recognized -- in fact, luminaries, in their fields....Williams continues to sustain its unparalleled reputation as THE textbook of hematology. I've run out of superlatives. Get it."--Doody's Review Service

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. The book begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Featuring a brand-new full-color presentation, the Eighth Edition of Williams Hematology is extensively revised to reflect the latest views of experts in the field. Two new chapters examine the importance of genomics in hematology and cell therapy for tissue replacement, whereas other chapters have been revised to incorporate the newest clinical approaches to the leukemias and lymphomas, and the application of targeted therapy in the treatment of hematologic disorders.

New to this Edition:

  • Full-color presentation conveniently integrates images of blood and tissue findings where they are cited in the text
  • Two additional chapters, “Genomics and Epigenetics,” and “Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement,” offer insights into the application of genomic and monoclonal therapies to hematology and emphasize their role in improving diagnostic and therapeutic methods
  • Expanded coverage of non-Hodgkin lymphoma includes separate chapters on its constituent diseases, providing an in-depth assessment of the diagnosis and management of these disorders
  • A comprehensive discussion of erythrocytosis and thrombocytosis reviews reactive and malignant forms of myeloproliferation, encompassing new genetic advances in these disorders along with more targeted therapeutic approaches
  • Companion CD includes a large selection of morphologies, illustrations, and drawings from the book, in a presentation-ready PowerPoint format
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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is the eighth edition of this comprehensive textbook of hematology. The previous edition was published in 2005.
Purpose: This edition continues the tradition of providing a comprehensive, updated textbook of hematology. This very worthy objective is spectacularly met by this edition.
Audience: As a textbook of hematology, this has a broad-based audience — medical students, residents, fellows, and practitioners (including our allied health partners) in virtually every aspect of medicine. The authors and editors are internationally recognized — in fact, luminaries — in their fields.
Features: There is a reason Williams has been the go-to textbook of hematology for generations. It is comprehensive, it has the answer to any question regarding hematology, it has the depth of detail to explain and justify the answers, and it contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. The continued exponential growth of research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment is extraordinarily well captured in this edition. There are 141 chapters in 2400 pages (yes, it is heavy). To impart a sense of the comprehensiveness of this book, the first chapter discusses the physical exam (very basic), whereas the single chapter on thrombocytosis in the previous edition has now been split into two chapters: reactive versus myeloproliferative (esoteric). New to this edition are chapters on epigenetics and genomics, and regenerative medicine. Not only does this edition contain all you could ever want to know about hematology, it has new features to take advantage of contemporary technology (iPhone/mobile apps) and connectedness (online version has hyperlinks to cited references, drug databases, Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th edition, Brunton et al. (McGraw-Hill, 2011), Harrison's Principles of Internal Medicine, 18th edition, Longo et al. (McGraw-Hill, 2011)). This edition also comes with a CD-ROM containing images (photomicrographs, illustrations, drawings) ready to snap into PowerPoint presentations. Very, very, very minor criticisms: some of the photomicrographs do not have color faithful reproduction (e.g., blue or yellow backgrounds), and the book is heavy. This latter issue can be completely obviated by using the online version, likely on your smartphone or tablet.
Assessment: Williams continues to sustain its unparalleled reputation as THE textbook of hematology. I've run out of superlatives. Get it.
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Product Details

  • ISBN-13: 9780071621519
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 7/9/2010
  • Edition description: New Edition
  • Edition number: 8
  • Pages: 2460
  • Sales rank: 1,411,038
  • Product dimensions: 9.00 (w) x 10.90 (h) x 3.00 (d)

Meet the Author

Kenneth Kaushansky, MD

Helen M. Ranney Professor and Chair

Department of Medicine

University of California, San Diego

La Jolla, CA

Marshall A. Lichtman, MD

Departments of Medicine and of Biochemistry and Biophysics

University of Rochester Medical School

Rochester, NY

Ernest Beutler, MD


Professor and Chairman

Department of Molecular and Experimental Medicine

The Scripps Research Institute

La Jolla, CA

Senior Consultant

Division of Hematology Oncology

Scripps Clinical Medical Group, Inc.

Clinical Professor of Medicine

University of California, San Diego

La Jolla, CA

Thomas J. Kipps, MD, PhD

Evelyn and Edwin Tasch Chair in Cancer Research

Professor of Medicine

Division of Hematology/Oncology

Deputy Director for Research Operations

Moores UCSD Cancer Center

University of California, San Diego

La Jolla, CA

Uri Seligsohn, MD

Professor and Director

Amalia Biron Research Institute of Thrombosis and Hemostatis

Department of Hematology

Chaim Sheba Medical Center

Tel-Hashomer and Sackler Faculty of Medicine

Tel Aviv University

Tel Aviv, Israel

Josef T. Prchal, MD

Professor of Medicine, Pathology, and Genetics

Hematology Division

University of Utah

Salt Lake City, UT

Department of Pathophysiology

First Faculty of Medicine

Charles University in Prague

Czech Republic

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Table of Contents



Part I Clinical Evaluation of the Patient

1 Initial Approach to the Patient: History and Physical Examination Ernest Beutler Beutler, Ernest 3

2 Examination of Blood Cells Daniel H. Ryan Ryan, Daniel H. 11

3 Examination of the Marrow Daniel H. Ryan Ryan, Daniel H. 25

Part II The Organization of the Lymphohematopoietic Tissues

4 Structure of the Marrow and the Hematopoietic Microenvironment Marshall A. Lichtman Lichtman, Marshall A. 41

5 The Organization and Structure of Lymphoid Tissues Thomas J. Kipps Kipps, Thomas J. 75

Part II Epochal Hematology

6 Hematology of the Fetus and Newborn George B. Segel Segel, George B. 87

7 Hematology during Pregnancy Josef T. Prchal Prchal, Josef T. 105

8 Hematology in Older Persons Dan L. Longo Longo, Dan L. 115

Part IV Molecular and Cellular Hematology

9 Genetic Principles and Molecular Biology Ernest Beutler Beutler, Ernest 129

10 Genomics and Epigenetics Lynn B. Jorde Jorde, Lynn B. 141

11 Cytogenetics and Molecular Abnormalities Michelle M. Le Beau Le Beau, Michelle M. 145

12 Apoptosis Roberta A. Gottlieb Gottlieb, Roberta A. 161

13 Cell-Cycle Regulation and Hematologic Disorders Dennis A. Carson Carson, Dennis A. 169

14 Signal Transduction Pathways Kenneth Kaushansky Kaushansky, Kenneth 183

15 The Cluster of Differentiation Antigens Thomas J. Kipps Kipps, Thomas J. 193

16 Hematopoietic Stem Cells, Progenitors, and Cytokines Kenneth Kaushansky Kaushansky, Kenneth 231

17 The Inflammatory Response Peter A. Ward Ward, Peter A. 251

18 Innate Immunity Bruce Beutler Beutler, Bruce 261

19 Dendritic Cells and the Control of Innate and Adaptive Immunity Ralph M. Steinman Steinman, Ralph M. 273

Part V Therapeutic Principles

20 Pharmacology and Toxicity of Antineoplastic Drugs Paul Richardson Richardson, Paul 283

21 Principles of Hematopoietic Cell Transplantation Robert S. Negrin Negrin, Robert S. 313

22 Treatment of Infections in the Immunocompromised Host Lisa Beutler Beutler, Lisa 343

23 Principles of Antithrombotic Therapy Mark Crowther Crowther, Mark 353

24 Principles of Immune Cell Therapy Stanley R. Riddell Riddell, Stanley R. 369

25 Principles of Vaccine Therapy Larry W. Kwak Kwak, Larry W. 379

26 Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications Bruce C. McLeod McLeod, Bruce C. 383

27 Principles of Gene Transfer for Therapy Thomas J. Kipps Kipps, Thomas J. 391

28 Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement Armand Keating Keating, Armand 401

Part VI The Erythrocyte

29 Morphology of the Erythron Paul C. Herrmann Herrmann, Paul C. 409

30 Composition of the Erythrocyte Ernest Beutler Beutler, Ernest 429

31 Production of Erythrocytes Josef T. Prchal Prchal, Josef T. 435

32 Destruction of Erythrocytes Ernest Beutler Beutler, Ernest 449

33 Clinical Manifestations and Classification of Erythrocyte Disorders Josef T. Prchal Prchal, Josef T. 455

34 Aplastic Anemia: Acquired and Inherited Marshall A. Lichtman Lichtman, Marshall A. 463

35 Pure Red Cell Aplasia Neal S. Young Young, Neal S. 485

36 Anemia of Chronic Renal Disease Ubaldo Martinez Outschoorn Outschoorn, Ubaldo Martinez 495

37 Anemia of Chronic Disease Tomas Ganz Ganz, Tomas 503

38 Anemia of Endocrine Disorders Josef T. Prchal Prchal, Josef T. 509

39 The Congenital Dyserythropoietic Anemias Jean Delaunay Delaunay, Jean 513

40 Paroxysmal Nocturnal Hemoglobinuria Charles J. Parker Parker, Charles J. 521

41 Folate, Cobalamin, and Megaloblastic Anemias Ralph Green Green, Ralph 533

42 Disorders of Iron Metabolism Ernest Beutler Beutler, Ernest 565

43 Anemia Resulting from Other Nutritional Deficiencies Ralph Green Green, Ralph 607

44 Anemia Associated with Marrow Infiltration Josef T. Prchal Prchal, Josef T. 613

45 The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseases Patrick G. Gallagher Gallagher, Patrick G. 617

46 Disorders of Red Cells Resulting from Enzyme Abnormalities Richard van Wijk van Wijk, Richard 647

47 The Thalassemias: Disorders of Globin Synthesis David J. Weatherall Weatherall, David J. 675

48 Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities Abdullah Kutlar Kutlar, Abdullah 709

49 Methemoglobinemia and Other Dyshemoglobinemias Josef T. Prchal Prchal, Josef T. 743

50 Hemolytic Anemia Resulting from Physical Injury to Red Cells Joel Moake Moake, Joel 755

51 Hemolytic Anemia Resulting from Chemical and Physical Agents Paul C. Herrmann Herrmann, Paul C. 763

52 Hemolytic Anemia Resulting from Infections with Microorganisms Marshall A. Lichtman Lichtman, Marshall A. 769

53 Hemolytic Anemia Resulting from Immune Injury Charles H. Packman Packman, Charles H. 777

54 Alloimmune Hemolytic Disease of the Fetus and Newborn Naomi L. C. Luban Luban, Naomi L. C. 799

55 Hypersplenism and Hyposplenism Ubaldo Martinez Outschoorn Outschoorn, Ubaldo Martinez 815

56 Primary and Secondary Polycythemias (Erythrocytosis) Josef T. Prchal Prchal, Josef T. 823

57 The Porphyrias Karl E. Anderson Anderson, Karl E. 839

58 Hereditary and Acquired Sideroblastic Anemias Josef T. Prchal Prchal, Josef T. 865

Part VII Neutrophils, Eosinophils, Basophils, and Mast Cells

59 Morphology of Neutrophils, Eosinophils and Basophils C. Wayne Smith Smith, C. Wayne 875

60 Composition of Neutrophils C. Wayne Smith Smith, C. Wayne 883

61 Production, Distribution, and Fate of Neutrophils C. Wayne Smith Smith, C. Wayne 891

62 Eosinophils and Their Disorders Andrew J. Wardlaw Wardlaw, Andrew J. 897

63 Basophils and Mast Cells and Their Disorders Ann M. Dvorak Dvorak, Ann M. 915

64 Classification and Clinical Manifestations of Neutrophil Disorders Marshall A. Lichtman Lichtman, Marshall A. 933

65 Neutropenia and Neutrophilia David C. Dale Dale, David C. 939

66 Disorders of Neutrophil Function Laurence A. Boxer Boxer, Laurence A. 951

Part VIII Monocytes and Macrophages

67 Morphology of Monocytes and Macrophages Florin Tuluc Tuluc, Florin 989

68 Biochemistry and Functions of Monocytes and Macrophages Siamon Gordon Gordon, Siamon 999

69 Production, Distribution, and Fate of Monocytes and Macrophages Annette Pluddemann Pluddemann, Annette 1021

70 Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages Marshall A. Lichtman Lichtman, Marshall A. 1035

71 Monocytosis and Monocytopenia Marshall A. Lichtman Lichtman, Marshall A. 1041

72 Inflammatory and Malignant Histiocytosis Carl E. Allen Allen, Carl E. 1047

73 Lipid Storage Diseases Deborah Elstein Elstein, Deborah 1065

Part IX Lymphocytes and Plasma Cells

74 Morphology of Lymphocytes and Plasma Cells H. Elizabeth Broome Broome, H. Elizabeth 1079

75 Composition and Biochemistry of Lymphocytes and Plasma Cells Thomas J. Kipps Kipps, Thomas J. 1087

76 Lymphopoiesis Gay M. Crooks Crooks, Gay M. 1095

77 Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production Thomas J. Kipps Kipps, Thomas J. 1105

78 Functions of T Lymphocytes: T-Cell Receptors for Antigen Thomas J. Kipps Kipps, Thomas J. 1119

79 Functions of Natural Killer Cells Lewis L. Lanier Lanier, Lewis L. 1131

80 Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders Thomas J. Kipps Kipps, Thomas J. 1137

81 Lymphocytosis and Lymphocytopenia Thomas J. Kipps Kipps, Thomas J. 1141

82 Immunodeficiency Diseases Luigi D. Notarangelo Notarangelo, Luigi D. 1153

83 Hematologic Manifestations of Acquired Immunodeficiency Syndrome Erin Gourley Reid Reid, Erin Gourley 1175

84 Mononucleosis Syndromes Robert F. Betts Betts, Robert F. 1199

Part X Neoplastic Myeloid Diseases

85 Classification and Clinical Manifestations of the Clonal Myeloid Disorders Marshall A. Lichtman Lichtman, Marshall A. 1211

86 Polycythemia Vera Jaroslav F. Prchal Prchal, Jaroslav F. 1223

87 Essential Thrombocythemia Anthony R. Green Green, Anthony R. 1237

88 Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia) Marshall A. Lichtman Lichtman, Marshall A. 1249

89 Acute Myelogenous Leukemia Marshall A. Lichtman Lichtman, Marshall A. 1277

90 Chronic Myelogenous Leukemia and Related Disorders Marshall A. Lichtman Lichtman, Marshall A. 1331

91 Primary Myelofibrosis Ayalew Tefferi Tefferi, Ayalew 1381

Part XI Malignant Lymphoid Diseases

92 Classification of Malignant Lymphoid Disorders Huan-You Wang Wang, Huan-You 1403

93 Acute Lymphoblastic Leukemia Ching-Hon Pui Pui, Ching-Hon 1409

94 Chronic Lymphocytic Leukemia and Related Diseases Thomas J. Kipps Kipps, Thomas J. 1431

95 Hairy Cell Leukemia Alan Saven Saven, Alan 1483

96 Large Granular Lymphocytic Leukemia Marshall E. Kadin Kadin, Marshall E. 1493

97 General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease Marshall A. Lichtman Lichtman, Marshall A. 1497

98 Pathology of Malignant Lymphomas Brian F. Skinnider Skinnider, Brian F. 1511

99 Hodgkin Lymphoma Sandra J. Horning Horning, Sandra J. 1527

100 Diffuse Large B-Cell Lymphoma Kenneth A. Foon Foon, Kenneth A. 1547

101 Follicular Lymphoma Oliver W. Press Press, Oliver W. 1565

102 Mantle Cell Lymphoma Peter W. McLaughlin McLaughlin, Peter W. 1575

103 Marginal Zone B-Cell Lymphomas Emanuele Zucca Zucca, Emanuele 1583

104 Burkitt Lymphoma Archibald S. Perkins Perkins, Archibald S. 1589

105 Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome) Larisa J. Geskin Geskin, Larisa J. 1595

106 Mature T-Cell and Natural Killer Cell Lymphomas Nam H. Dang Dang, Nam H. 1609

107 Plasma Cell Neoplasms: General Considerations H. Elizabeth Broome Broome, H. Elizabeth 1627

108 Essential Monoclonal Gammopathy Marshall A. Lichtman Lichtman, Marshall A. 1635

109 Myeloma Bart Barlogie Barlogie, Bart 1645

110 The Amyloidoses Joel N. Buxbaum Buxbaum, Joel N. 1683

111 Macroglobulinemia Giampaolo Merlini Merlini, Giampaolo 1695

112 Heavy-Chain Disease Robert A. Kyle Kyle, Robert A. 1709

Part XII Hemostasis and Thrombosis

113 Megakaryopoiesis and Thrombopoiesis Kenneth Kaushansky Kaushansky, Kenneth 1721

114 Platelet Morphology, Biochemistry, and Function Barry S. Coller Coller, Barry S. 1735

115 Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis Harold R. Roberts Roberts, Harold R. 1815

116 Control of Coagulation Reactions John H. Griffin Griffin, John H. 1845

117 Vascular Function in Hemostasis William A. Muller Muller, William A. 1863

118 Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis Kenneth Kaushansky Kaushansky, Kenneth 1883

119 Thrombocytopenia Jose A. Lopez Lopez, Jose A. 1891

120 Reactive Thrombocytosis Kenneth Kaushansky Kaushansky, Kenneth 1929

121 Hereditary Qualitative Platelet Disorders A. Koneti Rao Rao, A. Koneti 1933

122 Acquired Qualitative Platelet Disorders Joel S. Bennett Bennett, Joel S. 1971

123 The Vascular Purpuras Richard L. Gallo Gallo, Richard L. 1993

124 Hemophilia A and Hemophilia B Miguel A. Escobar Escobar, Miguel A. 2009

125 Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V And VIII and of the Vitamin K-Dependent Factors Ophira Salomon Salomon, Ophira 2031

126 Hereditary Fibrinogen Abnormalities Philippe de Moerloose de Moerloose, Philippe 2051

127 Von Willebrand Disease David Ginsburg Ginsburg, David 2069

128 Antibody-Mediated Coagulation Factor Deficiencies Pete Lollar Lollar, Pete 2089

129 Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation Philip G. De Groot De Groot, Philip G. 2095

130 Disseminated Intravascular Coagulation Uri Seligsohn Seligsohn, Uri 2101

131 Hereditary Thrombophilia Aaron Lubetsky Lubetsky, Aaron 2121

132 The Antiphospholipid Syndrome Jacob H. Rand Rand, Jacob H. 2145

133 Antibody-Mediated Thrombotic Disorders: Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia Mortimer Poncz Poncz, Mortimer 2163

134 Venous Thrombosis Graham F. Pineo Pineo, Graham F. 2185

135 Atherothrombosis: Disease Initiation, Progression, and Treatment Andrew I. Schafer Schafer, Andrew I. 2197

136 Fibrinolysis and Thrombolysis Jia Ruan Jia, Ruan 2219

Part XIII Transfusion Medicine

137 Erythrocyte Antigens and Antibodies Marion E. Reid Reid, Marion E. 2247

138 Human Leukocyte and Platelet Antigens Neil Blumberg Blumberg, Neil 2269

139 Blood Procurement and Screening Jeffrey McCullough McCullough, Jeffrey 2279

140 Red Cell Transfusion Neil Blumberg Blumberg, Neil 2287

141 Preservation and Clinical Use of Platelets Ralph Vassallo Vassallo, Ralph 2301

Index 2317

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