Williams Manual of Hematology, Eighth Edition / Edition 8

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A convenient full-color reference distilled from the world’s leading hematology text – perfect when you need answers in the office, clinic, or on hospital rounds.

Williams Manual of Hematology, 8e is a concise and easy-to-navigate compilation of the pathogenic, diagnostic, and therapeutic essentials of blood cell and coagulation protein disorders. Referenced to the classic Williams Hematology, 8e, this handy, easily transported reference has been carefully edited to deliver only the most clinical point-of-care facts.

Covering both common and uncommon blood disorders, this complete guide includes sections on:

  • Disorders of red cells
  • Disorders of granulocytes
  • Disorders of monocytes and macrophages
  • The clonal myeloid disorders
  • The polyclonal lymphoid diseases
  • The clonal lymphoid and plasma cell diseases
  • Disorders of platelets and hemostasis
  • Disorders of coagulation proteins
  • Transfusion and hemapheresis

Now in full color for the first time, Williams Manual of Hematology, 8e is the fastest and most convenient way to access the unmatched clinical authority of Williams Hematology, 8e.

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Product Details

  • ISBN-13: 9780071622424
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 5/10/2011
  • Edition description: New Edition
  • Edition number: 8
  • Pages: 756
  • Sales rank: 1,475,723
  • Product dimensions: 4.80 (w) x 8.30 (h) x 1.10 (d)

Meet the Author

Marshall A. Lichtman, MD

Professor of Medicine and of Biochemistry and Biophysics

University of Rochester Medical Center

Rochester, NY

Kenneth Kaushansky, MD

Senior Vice President, Health Sciences

Dean, School of Medicine

Stony Brook University

Stony Brook, NY

Thomas J. Kipps, MD, PhD

Evelyn and Edwin Tasch Chair in Cancer Research

Professor of Medicine

Division of Hematology/Oncology

Deputy Director for Research Operations

Moores UCSD Cancer Center

University of California, San Diego

La Jolla, CA

Josef T. Prchal, MD

Professor of Medicine, Pathology, and Genetics

Hematology Division

University of Utah

Salt Lake City, UT

Department of Pathophysiology

First Faculty of Medicine

Charles University of Prague

Czech Republic

Marcel M. Levi, MD, PhD

Chairman, Department of Medicine

Academic Medical Center

University of Amsterdam

The Netherlands

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Table of Contents

Ch. 1 Initial approach to the patient : history and physical examination 3
Ch. 2 Examination of the blood 11
Ch. 3 Examination of the marrow 21
Ch. 4 Structure of the marrow and the hematopoietic microenvironment 35
Ch. 5 The lymphoid tissues 73
Ch. 6 Hematology of the newborn 81
Ch. 7 Hematology during pregnancy 101
Ch. 8 Hematology in older persons 111
Ch. 9 Genetic principles and molecular biology 125
Ch. 10 Cytogenetics and gene rearrangement 137
Ch. 11 Apoptosis 151
Ch. 12 Cell cycle regulation and hematological disorders 159
Ch. 13 Signal transduction pathways 173
Ch. 14 The cluster of differentiation (CD) antigens 183
Ch. 15 Hematopoietic stem cells, progenitors, and cytokines 201
Ch. 16 The inflammatory response 221
Ch. 17 Innate immunity 231
Ch. 18 Dendritic cells and the control of innate and adaptive immunity 239
Ch. 19 Pharmacology and toxicity of antineoplastic drugs 249
Ch. 20 Treatment of infections in the immunocompromised host 275
Ch. 21 Principles of antithrombotic therapy 283
Ch. 22 Principles of hematopoietic cell transplantation 301
Ch. 23 Principles of immune cell therapy 323
Ch. 24 Principles of vaccine therapy 333
Ch. 25 Principles of therapeutic apheresis : indications, efficacy, complications 337
Ch. 26 Principles of gene transfer for therapy 345
Ch. 27 Pain management 355
Ch. 28 Morphology of the erythron 369
Ch. 29 Composition of the erythrocyte 387
Ch. 30 Production of erythrocytes 393
Ch. 31 Destruction of erythrocytes 405
Ch. 32 Clinical manifestations and classification of erythrocyte disorders 411
Ch. 33 Aplastic anemia 419
Ch. 34 Pure red cell aplasia 437
Ch. 35 Anemia of chronic renal failure 449
Ch. 36 Anemia of endocrine disorders 459
Ch. 37 The congenital dyserythropoietic anemias 463
Ch. 38 Paroxysmal nocturnal hemoglobinuria 469
Ch. 39 Folate, cobalamin, and megaloblastic anemias 477
Ch. 40 Disorders of iron metabolism 511
Ch. 41 Anemia resulting from other nutritional deficiencies 555
Ch. 42 Anemia associated with marrow infiltration 561
Ch. 43 Anemia of chronic disease 565
Ch. 44 Disorders of the red blood cell membrane : hereditary spherocytosis, elliptocytosis, and related disorders 571
Ch. 45 Disorders of red cells resulting from enzyme abnormalities 603
Ch. 46 Disorders of globin synthesis : the thalassemias 633
Ch. 47 Disorders of hemoglobin structure : sickle cell anemia and related abnormalities 667
Ch. 48 Methemoglobinemia and other causes of cyanosis 701
Ch. 49 Hemolytic anemia resulting from physical injury to red cells 709
Ch. 50 Hemolytic anemia resulting from chemical and physical agents 717
Ch. 51 Hemolytic anemia resulting from infections with microorganisms 723
Ch. 52 Hemolytic anemia resulting from immune injury 729
Ch. 53 Alloimmune hemolytic disease of the newborn 751
Ch. 54 Acute blood loss anemia 767
Ch. 55 Hypersplenism and hyposplenism 773
Ch. 56 Primary and secondary polycythemias (erythrocytosis) 779
Ch. 57 The hematologic aspects of porphyria 803
Ch. 58 Hereditary and acquired sideroblastic anemias 823
Ch. 59 Morphology of neutrophils, eosinophils, and basophils 831
Ch. 60 Composition of neutrophils 847
Ch. 61 Production, distribution, and fate of neutrophils 855
Ch. 62 Eosinophils and their disorders 863
Ch. 63 Basophils and mast cells and their disorders 879
Ch. 64 Classification and clinical manifestations of neutrophil disorders 899
Ch. 65 Neutropenia and neutrophilia 907
Ch. 66 Disorders of neutrophil function 921
Ch. 67 Morphology of monocytes and macrophages 961
Ch. 68 Biochemistry and function of monocytes and macrophages 971
Ch. 69 Production, distribution, and fate of monocytes and macrophages 979
Ch. 70 Classification and clinical manifestations of disorders of monocytes and macrophages 983
Ch. 71 Monocytosis and monocytopenia 987
Ch. 72 Inflammatory and malignant histiocytosis 993
Ch. 73 Lipid storage diseases 1009
Ch. 74 Morphology of lymphocytes and plasma cells 1023
Ch. 75 Composition and biochemistry of lymphocytes and plasma cells 1031
Ch. 76 Lymphopoiesis 1039
Ch. 77 Functions of B lymphocytes and plasma cells in immunoglobulin production 1051
Ch. 78 Functions of T lymphocytes : T cell receptors for antigen 1065
Ch. 79 Functions of natural killer cells 1077
Ch. 80 Classification and clinical manifestations of lymphocyte and plasma cell disorders 1083
Ch. 81 Lymphocytosis and lymphocytopenia 1087
Ch. 82 Immunodeficiency diseases 1099
Ch. 83 Hematological aspects of human immunodeficiency syndrome 1109
Ch. 84 Mononucleosis syndromes 1135
Ch. 85 Classification and clinical manifestations of the clonal myeloid disorders 1147
Ch. 86 Myelodysplastic syndromes (clonal cytopenias and oligoblastic leukemia) 1157
Ch. 87 Acute myelogenous leukemia 1183
Ch. 88 Chronic myelogenous leukemia and related disorders 1237
Ch. 89 Idiopathic myelofibrosis (myelofibrosis with myeloid metaplasia) 1295
Ch. 90 Classification of malignant lymphoid disorders 1315
Ch. 91 Acute lymphoblastic leukemia 1321
Ch. 92 Chronic lymphocytic leukemia and related diseases 1343
Ch. 93 Hairy cell leukemia 1385
Ch. 94 Large granular lymphocytic leukemia 1395
Ch. 95 Pathology of lymphomas 1399
Ch. 96 The non-Hodgkin lymphomas 1407
Ch. 97 Hodgkin lymphoma 1461
Ch. 98 Plasma cell neoplasms : general considerations 1483
Ch. 99 Essential monoclonal gammopathies 1491
Ch. 100 Plasma cell myeloma 1501
Ch. 101 The amyloidoses 1535
Ch. 102 Macroglobulinemia 1549
Ch. 103 Heavy chain diseases 1561
Ch. 104 Megakaryopoiesis and thrombopoiesis 1571
Ch. 105 Platelet morphology, biochemistry, and function 1587
Ch. 106 Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis 1665
Ch. 107 Control of coagulation reactions 1695
Ch. 108 Vascular function in hemostasis 1715
Ch. 109 Classification, clinical manifestations, and evaluation of disorders of hemostasis 1741
Ch. 110 Thrombocytopenia 1749
Ch. 111 Essential thrombocythemia and thrombocytosis 1785
Ch. 112 Hereditary qualitative platelet disorders 1795
Ch. 113 Acquired qualitative platelet disorders 1833
Ch. 114 The vascular purpuras 1857
Ch. 115 Hemophilia A and hemophilia B 1867
Ch. 116 Inherited deficiencies of coagulation factors II, V, VII, X, XI, and XIII and combined deficiencies of factors V and VIII and of the vitamin K-dependent factors 1887
Ch. 117 Hereditary fibrinogen abnormalities 1909
Ch. 118 Von Willebrand disease 1929
Ch. 119 Antibody-mediated coagulation factor deficiencies 1947
Ch. 120 Hemostatic dysfunction related to liver diseases and liver transplantation 1953
Ch. 121 Disseminated intravascular coagulation 1959
Ch. 122 Hereditary thrombophilia 1981
Ch. 123 The antiphospholipid syndrome 2009
Ch. 124 Antibody-mediated thrombotic disorders : idiopathic thrombotic thrombocytopenic purpura and heparin-induced thrombocytopenia 2031
Ch. 125 Venous thrombosis 2055
Ch. 126 Atherothrombosis : disease initiation, progression, and treatment 2067
Ch. 127 Fibrinolysis and thrombolysis 2089
Ch. 128 Erythrocyte antigens and antibodies 2119
Ch. 129 Human leukocyte and platelet antigens 2137
Ch. 130 Blood procurement and screening 2151
Ch. 131 Preservation and clinical use of erythrocytes and whole blood 2159
Ch. 132 Preservation and clinical use of platelets 2175
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