Wintrobe's Clinical Hematology / Edition 11

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Overview

With the 13th edition of Wintrobe’s Clinical Hematology, this new edition once again bridges the gap between the clinical practice of hematology and the basic foundations of science.  

Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of  Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues.

With the knowledge about gene therapy and immunotherapy expanding, the book includes new, up-to-date information about the process and application of these therapies. Likewise, the editors have  shed a completely new light on the process of stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.

The textbook features an online, interactive companion that has a reference list for each chapter as well as two appendices one reviewing the clusters of differentiation (CD) molecules and one that reviews lab values and photomicrographs of the blood of animals.

Along with these tools, the authors plan to post updates online when they are particularly pertinent or important. 

Features:
Greater emphasis on molecular genetics and flow cytometry
Increased number of hematopathology illustrations
Expanded coverage of Transplantation
Online companion with reference features and relevant updates

First published in 1942, Wintrobe's Clinical Hematology continues its tradition of excellence in correlating basic science with the clinical practice of hematology. This is the most comprehensive hematology book on the market and is organized to help physicians find clinical answers quickly and easily. The Eleventh Edition places a greater emphasis on clinical hematology, especially molecular aspects and new therapies. Most chapters have been revised or reconfigured, and seven new chapters have been added: Gene Therapy, Congenital Immunodeficiency Syndromes, Acute Lymphocytic Leukemia in Adults, Acute Myelogenous Leukemia in Children, Acute Promyelocytic Leukemia, Systemic Mastocytosis, and Diagnosis and Classification of Lymphoproliferative Disorders.

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Editorial Reviews

From The Critics
Reviewer: Hau C Kwaan, MD, PhD (Northwestern University Feinberg School of Medicine)
Description: This 12th edition of Wintrobe's Clinical Hematology incorporates many new features while continuing to uphold the tradition of a comprehensive, multidisciplinary textbook. Most illustrations, whether photographs or diagrams, are in full color, the full text is now accessible online, and two new editors and a number of new contributors reflect the need to keep pace with the rapid progress in this field.
Purpose: This valuable resource provides a much-needed update in the field of hematology.
Audience: Although targeted primarily at hematologists, this book also is valuable for those not in this field.
Features: "The most notable feature of this edition is the inclusion of new diagnostic approaches, particularly the use of immunophenotyping and cytogenetics. There are many outstanding chapters, especially in those areas that have seen the most recent advances, among them the well-illustrated chapter on acute promyelocytic leukemia. Detailed information on the pathogenesis and complete guidance for the management of this disease and its complex complications illustrates why this disorder has the highest cure rate among the leukemias, yet is the most feared because of its complications. Other impressive features include the update on the ever-expanding number of new chemotherapeutic drugs with detailed information on their action and adverse effects. The chapter on molecular genetics provides deeper insight into the pathogenesis of many disorders. Inevitably, some major new advances do not receive sufficient attention. For example, the importance of the JAK2 V617F mutation, considered one of two major criteria by WHO, is mentioned just briefly in the approach to the diagnosis of polycythemia vera. Also, thrombolytic therapy is omitted entirely. "
Assessment: Overall, this edition provides ample evidence why this is a unique book in hematology, unsurpassed in its broad coverage of topics and its state-of-the-art information. It will be treasured by all clinicians who have to deal with patients with hematologic disorders.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780781736503
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 11/24/2003
  • Edition description: Eleventh Edition
  • Edition number: 11
  • Pages: 2800
  • Product dimensions: 9.50 (w) x 11.75 (h) x 5.75 (d)

Table of Contents

Contributing Authors
Preface
Color Plates follow p. xviii
1 Examination of the Blood and Bone Marrow 3
2 Clusters of Differentiation 27
3 Clinical Flow Cytometry 99
4 Cytogenetics 131
5 Molecular Biology and Hematology 153
6 Origin and Development of Blood Cells 169
7 Erythropoiesis 195
8 The Mature Erythrocyte 217
9 Destruction of Erythrocytes 249
10 Neutrophilic Leukocytes 267
11 The Human Eosinophil 311
12 Basophilic Leukocytes: Mast Cells and Basophils 335
13 Mononuclear Phagocytes 349
14 Phagocytosis 387
15 Lymphocytes and Lymphatic Organs 409
16 B Lymphocytes 439
17 T Lymphocytes and Natural Killer Cells 475
18 Effector Mechanisms in Immunity 527
19 Megakaryocytes and Platelets 605
20 Platelet Function in Hemostasis and Thrombosis 651
21 Blood Coagulation and Fibrinolysis 677
22 Endothelium: Angiogenesis and the Regulation of Hemostasis 775
23 Red Cell, Platelet, and White Cell Antigens 791
24 Transfusion Medicine 831
25 Hematopoietic Stem Cell Transplantation 883
26 Gene Therapy for Hematologic Disorders, Human Immunodeficiency Virus Infection, and Cancer 911
27 Anemia: General Considerations 947
28 Iron Deficiency and Related Disorders 979
29 Sideroblastic Anemias 1011
30 Hemochromatosis 1035
31 Porphyria 1057
32 Hereditary Spherocytosis and Other Anemias Due to Abnormalities of the Red Cell Membrane 1089
33 Hereditary Hemolytic Anemias Due to Enzyme Disorders 1115
34 Mechanisms of Immune Destruction of Erythrocytes 1141
35 Autoimmune Hemolytic Anemias 1157
36 Alloimmune Hemolytic Disease of the Fetus and Newborn 1183
37 Paroxysmal Nocturnal Hemoglobinuria 1203
38 Acquired Nonimmune Hemolytic Disorders 1223
39 Abnormal Hemoglobins: General Principles 1247
40 Sickle Cell Anemia and Other Sickling Syndromes 1263
41 Unstable Hemoglobin Disease 1313
42 Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis 1319
43 Megaloblastic Anemias: Disorders of Impaired DNA Synthesis 1367
44 Acquired and Inherited Aplastic Anemia Syndromes 1397
45 Red Cell Aplasia 1421
46 Congenital Dyserythropoietic Anemias 1439
47 Anemias Secondary to Chronic Disease and Systemic Disorders 1445
48 Anemias Unique to Pregnancy and the Perinatal Period 1467
49 Hemoglobins Associated with Cyanosis: Methemoglobinemia and Low-Affinity Hemoglobins 1487
50 Erythrocytosis 1495
51 Diagnostic Approach to the Bleeding Disorders 1511
52 Thrombocytopenia: Pathophysiology and Classification 1529
53 Thrombocytopenia Caused by Immunologic Platelet Destruction 1533
54 Thrombotic Thrombocytopenic Purpura and Other Forms of Nonimmunologic Platelet Destruction 1555
55 Miscellaneous Causes of Thrombocytopenia 1565
56 Bleeding Disorders Caused by Vascular Abnormalities 1573
57 Thrombocytosis 1591
58 Qualitative Disorders of Platelet Function 1603
59 Inherited Coagulation Disorders 1619
60 Acquired Coagulation Disorders 1669
61 Thrombosis and Antithrombotic Therapy 1713
62 Diagnostic Approach to Malignant and Nonmalignant Disorders of the Phagocytic and Immune Systems 1761
63 Neutropenia 1777
64 Qualitative Disorders of Leukocytes 1801
65 Abnormalities of the Monocyte-Macrophage System: Lysosomal Storage Diseases 1819
66 Langerhans Cell Histiocytosis 1827
67 Infectious Mononucleosis and Other Epstein-Barr Virus-Related Disorders 1837
68 Primary Immunodeficiency Syndromes 1863
69 Acquired Immunodeficiency Syndrome 1875
70 Disorders of the Spleen 1893
71 Hematopoietic-Lymphoid Neoplasms: Principles of Diagnosis 1913
72 Complications of Hematopoietic Neoplasms 1919
73 Principles and Pharmacology of Chemotherapy 1945
74 Immunotherapy 1971
75 Supportive Care in Hematologic Malignancies 1997
76 Molecular Genetics of Acute Leukemia 2045
77 Classification and Differentiation of the Acute Leukemias 2063
78 Acute Lymphoblastic Leukemia in Adults 2077
79 Acute Myeloid Leukemia in Adults 2097
80 Acute Lymphoblastic Leukemia in Children 2143
81 Acute Myelogenous Leukemia in Children 2169
82 Acute Promyelocytic Leukemia 2191
83 Myelodysplastic Syndromes 2207
84 Chronic Myeloid Leukemia 2235
85 Polycythemia Vera 2259
86 Myelofibrosis 2273
87 Systemic Mastocytosis 2285
88 Diagnosis and Classification of Non-Hodgkin Lymphomas 2301
89 Molecular Aspects of Non-Hodgkin Lymphomagenesis 2325
90 Non-Hodgkin Lymphomas in Adults 2363
91 Non-Hodgkin Lymphomas in Children 2411
92 Chronic Lymphocytic Leukemia 2429
93 Hairy Cell Leukemia 2465
94 Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sezary Syndrome 2485
95 Hodgkin Disease 2521
96 Practical Aspects of the Clinical Approach to Patients with Monoclonal Immunoglobulin Disorders 2555
97 Monoclonal Gammopathy of Undertermined Significance and Smoldering Multiple Myeloma 2565
98 Multiple Myeloma 2583
99 Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) 2637
100 Waldenstrom Macroglobulinemia 2667
101 Cryoglobulinemia, Heavy Chain Diseases, and Monoclonal Gammopathy-Associated Disorders 2683
App. A Normal Blood and Bone Marrow Values in Humans 2697
App. B Comparative Hematology 2707
Index
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