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Doody's Review ServiceReviewer: Hau C Kwaan, MD, PhD (Northwestern University Feinberg School of Medicine)
Description: This 12th edition of Wintrobe's Clinical Hematology incorporates many new features while continuing to uphold the tradition of a comprehensive, multidisciplinary textbook. Most illustrations, whether photographs or diagrams, are in full color, the full text is now accessible online, and two new editors and a number of new contributors reflect the need to keep pace with the rapid progress in this field.
Purpose: This valuable resource provides a much-needed update in the field of hematology.
Audience: Although targeted primarily at hematologists, this book also is valuable for those not in this field.
Features: The most notable feature of this edition is the inclusion of new diagnostic approaches, particularly the use of immunophenotyping and cytogenetics. There are many outstanding chapters, especially in those areas that have seen the most recent advances, among them the well-illustrated chapter on acute promyelocytic leukemia. Detailed information on the pathogenesis and complete guidance for the management of this disease and its complex complications illustrates why this disorder has the highest cure rate among the leukemias, yet is the most feared because of its complications. Other impressive features include the update on the ever-expanding number of new chemotherapeutic drugs with detailed information on their action and adverse effects. The chapter on molecular genetics provides deeper insight into the pathogenesis of many disorders. Inevitably, some major new advances do not receive sufficient attention. For example, the importance of the JAK2 V617F mutation, considered one of two major criteria by WHO, is mentioned just briefly in the approach to the diagnosis of polycythemia vera. Also, thrombolytic therapy is omitted entirely.
Assessment: Overall, this edition provides ample evidence why this is a unique book in hematology, unsurpassed in its broad coverage of topics and its state-of-the-art information. It will be treasured by all clinicians who have to deal with patients with hematologic disorders.