Workshop on Disseminated Intravascular Coagulation

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Table of Contents

Preface
Acknowledgements
Attempts to define disseminated intravascular coagulation 3
Bacteria, cells and disseminated intravascular coagulation in man 11
Role of tissue factor in the coagulant and inflammatory response to LD[subscript 100] E. coli sepsis and in the early diagnosis of DIC in the baboon 19
Leukocytes, adhesive proteins and disseminated intravascular coagulation: treatment of DIC with plasma/leukapheresis? 32
Tissue factor gene regulation 41
Tissue factor expression in endotoxin-activated monocytes is suppressed by agents which increase intracellular cyclic AMP concentration 47
Involvement of the vascular endothelium and activation of the coagulation system in human malaria 51
Effect of peripheral blood lymphocytes on procoagulant activity of human endothelial cells pretreated with lipopolysaccharide 55
Freshly formed thrombi induce procoagulant activity in human vascular endothelial cells 63
Hemostasis in orthotopic liver transplantation - a model for studying DIC development? 71
Markers of hemostatic activation in experimental endotoxemia: implications for therapy 81
Quantitative evaluation of hypercoagulability by fibrin monomer ELISA 89
Determination of plasma fibrin monomers by a newly developed ELISA method in patients with disseminated intravascular coagulation 99
Soluble fibrin - a predictor for development and outcome of multiple organ failure 111
Monitoring the anticoagulant treatment of DIC and recurrent thrombosis in patients with malignancies using the measurement of "soluble fibrin" (FM-test, Chromogenix), F1+2 and TAT complexes 113
Degradation of fibrinogen and its derivatives in the course of disseminated intravascular coagulation 117
Evidence that heparin cofactor II participates in the control of disseminated intravascular coagulation 125
Cytokine release in leukocytopenic patients with septic shock is associated with coagulation activation and consumption of inhibitors 129
Increased activated protein C - its inhibitor complex levels in patients with disseminated intravascular coagulation 131
Activation of hemostasis and the release of cytokines following the injection of bacterial lysates: fibrinolysis precedes fibrinemia 139
Alterations of coagulation and fibrinolysis during the preclinical phase after polytrauma 147
Alterations of coagulation inhibitors in consumption coagulopathy 159
Hypercoagulation predicts outcome after isolated brain trauma 163
Sepsis and septic shock: hemostasis-fibrinolysis equilibrium as a prognostic factor and an indicator during therapy 165
Influence of blood sampling from venipunctures and catheter systems on serial determinations of prothrombin activation fragment 1+2 and thrombin-antithrombin III complex
Hypercoagulable state and DIC in neonatal asphyxia 175
New developments in the field of benzamidine-derived thrombin inhibitors 183
Investigation of in vitro antithrombotic potency of a r-hirudin (HBW 023) and a synthetic analogue 191
Heparin treatment in thrombin-induced disseminated intravascular coagulation (DIC) in the baboon 197
Clinical evaluation of low-molecular-weight heparin (FR-860) on disseminated intravascular coagulation (DIC). A multicenter cooperative double-blind trial in comparison with heparin 203
Protection of DIC-induced mortality in Klebsiella pneumoniae-infected and LPS-treated rats by antithrombin III 215
Results of a double-blind, placebo-controlled trial of antithrombin III concentrates in septic shock with DIC 221
Antithrombin concentrate dose to patients with acquired antithrombin deficiency 227
Effect of two-domain tissue factor pathway inhibitor (2D-TFPI) and inactivated factor VIIa on endotoxin-induced DIC in rabbits 229
Antithrombotic effects of recombinant soluble human thrombomodulin analogs in animal models of tissue-factor and thrombin induced DIC 233
The xanthine derivatives HWA 138 and A 80 attenuate activation of coagulation in porcine endotoxin shock 239
Effect of nafamostat mesilate (NM), a synthetic protease inhibitor, on the extrinsic pathway of coagulation 243
The use of Octaplas in patients undergoing open heart surgery 253
Index of authors 263
Keyword index 265
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