Wound Healing in Cardiovascular Disease / Edition 1

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Overview

An international group of clinicians and biomedical scientists interested in abnormal cardiovascular structure and organ failure present their perspectives on inflammation and wound healing in cardiovascular disease. Emphasis is placed on expressions of wound healing, such as myocardial infarction and rupture, chronic ischemic heart disease, the dilated failing heart, myocarditis, endomyocardial fibrosis, and coronary restenosis following revascularization.
The significance of the regulatory aspects of wound healing is also highlighted, which addresses the regulation of collagen turnover and collagen degradation in the diseased heart, aorta, and atherosclerotic lesion; the association between circulating peptide and steroid hormones and myocardial fibrosis; the role of locally produced peptides in promoting tissue repair; the potential association between angiotensin I-converting enzyme gene, polymorphism and cardiovascular risk; the regulation of fibrillar collagen gene expression.
This text offers an enhanced perspective of inflammation and wound healing in cardiovascular disease. Essential information regarding wound healing in specific cardiovascular disease states such as myocardial infarction and rupture, congent manner that will be useful to all cardiologists and cardiac surgeons. This international group of authors also offers a stimulating analysis of the regulatory aspects of wound healing

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Joseph F. Stella, DO (Loyola University Stritch School of Medicine)
Description: This new book adequately describes the detailed aspects of wound healing in various cardiovascular disorders and adaptive processes, both beneficial and pathologic, that occur as compensatory mechanisms.
Purpose: The purpose is to describe in great detail several different types of wounds or injuries to cardiovascular structures. The author easily realizes his objective. He first starts with an intricate description of the body's normal physiologic and cellular response to a various wound injury or pathologic process. Next, he describes the effect of various hormones both endogenous and erogenous, proteins, drugs and mechanical factors that can influence the body's response to the aforementioned insult. Finally, he describes in a cellular and somewhat clinical manner the reparative process and any therapeutic regimens that can alter the pathologic state or affect the patient's prognosis.
Audience: The primary audience for this book is cardiovascular research scientists. In addition, some general cardiologists may find this book of particular use. The author is a well-known and respected figure in the field of cardiovascular disease.
Features: The author appropriately uses an adequate number of graphs, charts, and pictures to help enable the reader to fully understand various concepts in this text. The references in this book are numerous and up-to-date.
Assessment: I believe that this is a well-written, unique book that would be useful for a cardiovascular research scientist. This book goes in-depth to explain cardiovascular wound healing in different pathologic states and different factors that can alter the body's response to these insults. In short, it would be a welcome addition to a cardiovascular scientist's library.
Joseph F. Stella
This new book adequately describes the detailed aspects of wound healing in various cardiovascular disorders and adaptive processes, both beneficial and pathologic, that occur as compensatory mechanisms. The purpose is to describe in great detail several different types of wounds or injuries to cardiovascular structures. The author easily realizes his objective. He first starts with an intricate description of the body's normal physiologic and cellular response to a various wound injury or pathologic process. Next, he describes the effect of various hormones both endogenous and erogenous, proteins, drugs and mechanical factors that can influence the body's response to the aforementioned insult. Finally, he describes in a cellular and somewhat clinical manner the reparative process and any therapeutic regimens that can alter the pathologic state or affect the patient's prognosis. The primary audience for this book is cardiovascular research scientists. In addition, some general cardiologists may find this book of particular use. The author is a well-known and respected figure in the field of cardiovascular disease. The author appropriately uses an adequate number of graphs, charts, and pictures to help enable the reader to fully understand various concepts in this text. The references in this book are numerous and up-to-date. I believe that this is a well-written, unique book that would be useful for a cardiovascular research scientist. This book goes in-depth to explain cardiovascular wound healing in different pathologic states and different factors that can alter the body's response to these insults. In short, it would be a welcome addition to a cardiovascular scientist'slibrary.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780879936204
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/28/1995
  • Edition number: 1
  • Pages: 380

Table of Contents

Contributors
Preface
Ch. 1 Inflammation and Healing in the Heart 1
Ch. 2 Wound Healing Response after Myocardial Infarction: Structural and Pharmacological Aspects 23
Ch. 3 Wound Healing After Myocardial Infarction 33
Ch. 4 Myocardial Rupture Postinfarction 49
Ch. 5 Chronic Ischemic Heart Disease 61
Ch. 6 Myocardial Collagenase in the Failing Human Heart 67
Ch. 7 Myocardial Collagenase Activity in Experimental Dilated Cardiomyopathy 73
Ch. 8 The Extracellular Matrix with the Development and Regression from Dilated Cardiomyopathy 83
Ch. 9 Myocarditis 99
Ch. 10 Endomyocardial Fibrosis 127
Ch. 11 Vascular Wound Healing and Restenosis Following Revascularization 137
Ch. 12 The Regulation of Collagen Turnover in the Normal, Hypertrophying and Fibrotic Heart 151
Ch. 13 Collagen Degradation After Myocardial Infarction 169
Ch. 14 The Pathogenesis of Atherosclerosis 179
Ch. 15 Proteinases and Inhibitors in Aortic Aneurysms 195
Ch. 16 Circulating Hormones of the Renin-Angiotensin-Aldosterone System and Myocardial Fibrosis in Left Ventricular Hypertrophy 211
Ch. 17 Locally Produced Substances and Tissue Repair 225
Ch. 18 Connective Tissue Ace 233
Ch. 19 Role of Endothelial Derived Signals 241
Ch. 20 Activation of Angiotensin II Receptors in the Postinfarcted Heart and Myocyte Growth Processes 249
Ch. 21 The Human Angiotensin I-Converting Enzyme Polymorphism and Its Implication in Cardiovascular Diseases 265
Ch. 22 Regulation of Fibrillar Collagen Gene Expression 281
Ch. 23 In Search of Common Ground 295
Index 307
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