The Wrinkle Cure: Unlock the Power of Cosmeceuticals for Supple, Youthful Skin


Look Ten Years Younger in Days-Without Surgery! From Yale University's dermatological and anti-aging expert Nicholas Perricone, M.D., comes the all-natural program that has already helped thousands-including top Hollywood stars. This antioxidant plan revitalizes your skin from the outside and inside, reducing and effectively erasing wrinkles and blemishes, no matter your skin color or type, no matter your age! Find out About: Alpha Lipoic Acid-lines, wrinkles, under-eye puffiness, acne scars, and enlarged pores ...

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Look Ten Years Younger in Days-Without Surgery! From Yale University's dermatological and anti-aging expert Nicholas Perricone, M.D., comes the all-natural program that has already helped thousands-including top Hollywood stars. This antioxidant plan revitalizes your skin from the outside and inside, reducing and effectively erasing wrinkles and blemishes, no matter your skin color or type, no matter your age! Find out About: Alpha Lipoic Acid-lines, wrinkles, under-eye puffiness, acne scars, and enlarged pores can disappear. The Three-Day Diet for Better Skin-special "face-changing" foods visibly alter the way you look, in just seventy-two hours. Vitamin C Ester-this miracle supplement can heal sun-damaged skin or inflammations by helping your body produce collagen-it firms up sagging skin as well! An Instant Face-Lift-DMAE tightens skin almost instantly and offers long-lasting results with continued use. And quickly plumps up lips, too! The Sugar Taboo-simple carbs ravage your skin and speed aging. Find out how to reverse the damage!

"...presents an all-natural antioxidant program for skin rejuvenation that goes beyond surfaces fixes and produces long-lasting results."

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Editorial Reviews

From Barnes & Noble
The Barnes & Noble Review
Not confined -- despite its title -- to fending off those pesky wrinkles, this is a guide to maintaining a healthy, supple, and glowing complexion at any age, without plastic surgery. Dr. Perricone, a renowned dermatologist, instructs readers on reaping the benefits of antioxidants and cosmeceuticals, as well as the lasting effects of sound nutrition.

The book asserts that much of what we consider the natural effects of aging on the skin is actually quite avoidable. The lines, wrinkles, discoloration, and loss of firmness and moisture that accrue over the years are not the result of the body's aging process; they are in fact the result of exposure to free radicals released by contact with the sun, chemicals, stress, cosmetics, and other forms of maltreatment. The explanation of the damage caused by free radicals and the ways in which antioxidants counterbalance this damage is truly eye-opening. In addition to the skin-saving techniques imparted by the book, readers will come away with a clear understanding of the science of aging, especially as it relates to their skin.

To help patients, and now readers, combat the ravages of free radicals, Dr. Perricone has formulated a program that incorporates antioxidants found in vegetables and topical antioxidant treatments he has termed cosmeceuticals, like vitamin C ester, DMAE, and alpha lipoic acid. These cosmeceuticals -- a cross between cosmetics and pharmaceuticals -- allow antioxidants to be absorbed readily by the skin, which uses them to stabilize free radicals. The book presents numerous stories of patients who turned to cosmeceuticals instead of facelifts, to demonstrate the effectiveness of the program. These stories are a highlight of the book, as they provide compelling examples of the power of antioxidants to repair not only the skin but also the self-esteem of users of all ages.

The premise of the book is that treating your skin well -- from the inside as well as the outside -- ought to be an imperative part of anyone's health and beauty regimen. By nourishing our bodies with antioxidant-rich foods and protecting our skin from the sun and other exterior hazards, we can all enjoy luminous skin well into our golden years. And if it's too late for such precautionary measures, there's always The Wrinkle Cure to help. (Karen Burns)

From the Publisher
"Working on some of the most beautiful faces and bodies in the world demands that I keep up with any and all important scientific findings. I'm a big fan of Dr. Perricone's skin care technology— it's the most profound and effective breakthrough that I've seen."—Matthew Van Leeuwen, celebrity makeup artist

"Dr. Perricone's years of clinical and laboratory research have resulted in technological breakthroughs. Powerful antioxidants are actually proving to rejuvenate wrinkled skin."—Harry G. Preuss, M.D., professor of medicine, Georgetown University

"Dr. Perricone brings science to the art of beauty. His breakthrough treatments are pivotal to the success of my artistry."—Maria Verel, celebrity makeup artist

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Product Details

  • ISBN-13: 9780446677769
  • Publisher: Grand Central Publishing
  • Publication date: 4/25/2001
  • Edition description: Reprint
  • Pages: 224
  • Sales rank: 325,313
  • Product dimensions: 5.50 (w) x 8.00 (h) x 0.75 (d)

Meet the Author

Nicholas Perricone, M.D., is assistant clinical professor of dermatology at Yale University School of Medicine and has a private practice in Connecticut. He is the author of numerous scientific papers that report his research on aging skin. The doctor is chairman of the prestigious annual International Conference on Aging Skin, which brings together leading researchers from around the world to exchange recent scientific breakthroughs on prevention of the aging process.


Nicholas Perricone, M.D., FACN, is a board certified clinical and research dermatologist. A brilliant scholar, Dr. Perricone completed medical school in just 2 1/2 years, graduating at the head of his class. He completed his internship in pediatrics at Yale Medical School and his dermatology residency at Ford Medical Center. Dr. Perricone is regarded as the father of the inflammation theory of aging. He is the author of the New York Times bestseller The Wrinkle Cure (Rodale Reach, May 2000). Warner Books published the trade paper edition in May of 2001. It reached No. 1 on both the New York Times and the Los Angeles Times bestseller lists on March 24, 2002, and remained there for four weeks. Close to one million copies are in print. His PBS-TV special of the same name is one of the top fundraisers for public television.

Dr. Perricone is certified by the American Board of Dermatology, is a fellow of the New York Academy of Sciences and a fellow of the American College of Nutrition. He is also a fellow of the American Academy of Dermatology and the Society of Investigative Dermatology. He is the recipient of the 2002 Eli Whitney Award, awarded annually to an outstanding individual for significant contribution to science.

Prior recipients include National Medal of Science recipient, Igor Sikorsky, (founder of Sikorsky aircraft) inventor of the first practical helicopter, which established the bedrock upon which today's helicopter industry rests, and Buckminster Fuller, inventor of the geodesic dome -- the lightest, strongest, and most cost-effective structure ever devised.

Dr. Perricone holds dozens of U.S. and international patents for the treatment of skin and systemic disease, and for the use of topical anti-inflammatories for reversing and preventing damage to skin caused by age, the sun, the environment, hormonal changes, etc. He is the author of numerous scientific articles documenting the results of his research and is a contributing editor to the peer-reviewed medical journal Skin and Aging and is a member of the editorial board of Archives of Gerontology & Geriatrics. He is chairman of the International Symposium on Aging Skin, an annual meeting in which researchers come together from around the world to share their latest scientific breakthroughs in the prevention of aging and aging skin.

Vogue magazine has named Dr. Perricone one of the top four dermatologists in the United States.

His book The Perricone Prescription, A Physician's 28-Day Program for Total Body and Face Rejuvenation, was published by HarperCollins to coincide with the premiere of his second television special for PBS-TV, the leading national educational television network, in September 2002.

Author biography courtesy of HarperCollins.

Good To Know

When Kim Cattrall had a skin emergency while filming HBO's Sex and the City, Perricone was summoned to the set to deliver a vitamin-enriched moisturizer that saved the day.

According to Dr. Perricone, the two best things you can add to your diet are salmon and berries.

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    1. Hometown:
    1. Education:
      Michigan State University

Table of Contents

Chapter 1 Beautiful Skin for Life 1
Good Nutrition for a Great Complexion 2
The Cosmeceutical Alternative 6
Chapter 2 Understanding Aging Skin 9
The Skin You're In 10
Why Our Skin Ages 12
The Free-Radical Theory of Aging 13
Antioxidants to the Rescue 17
Chapter 3 Taking Care of Your Skin 21
Treat Your Skin Tone Right 23
White Skin 23
Brown Skin 25
Light Brown or Yellow Skin 28
Treat Your Skin Type Right 31
Dry Skin 31
Oily Skin 33
Combination Skin 35
The Gender Gap 36
Chapter 4 How Skin Cells Age: Free Radicals and the Inflammation-Aging Connection 45
Understanding Free Radicals 46
The Theory That Started a Revolution 48
Protecting Cells from Free-Radical Damage 50
Free Radicals and Inflammation 54
The Final Frontier 56
Chapter 5 Vitamin C Ester: An All-Star Antioxidant 57
The Antioxidant Avenger 58
How Vitamin C Saves Your Skin 59
From Failure to Hope 60
The Breakthrough: Vitamin C Ester 61
Youth in a Jar 64
Chapter 6 Alpha Lipoic Acid: Nature's Most Powerful Antioxidant and Anti-Inflammatory 67
The Alpha Lipoic-Inflammation Connection 70
The Sugar-Aging Connection 72
From the Lab to Life 75
Chapter 7 DMAE: An Instant Anti-Aging Face-Life 81
Why Your Skin Goes South 82
How DMAE Helps 85
Soothing Super-Stressed Skin 85
Putting DMAE to the Test 86
Fuller, Firmer Lips 88
A Bonanza for Your Body, Too 89
Chapter 8 Undercover Antioxidants: Alpha Hydroxy and Beta Hydroxy Acids 91
An Ancient Beauty Secret 92
Hydroxies in Medicine 93
The Alphas and Betas of 2000 97
Chapter 9 Beauty from the Inside Out: The Anti-Inflammatory Diet 101
The Future of Healthy Eating 103
The Meal Plan 112
Chapter 10 Creating an Antioxidant Safety Net 119
Vitamins: Your Daily Dose 121
Minerals 129
Other Important Supplements 131
Chapter 11 Beyond Skin: Staying One Step Ahead of the Aging Process 139
Medicine to Keep the Body Young 141
Anti-Aging Consultation 143
Anti-Aging Consultation 2 Harry 161
Anti-Aging Consultation 3 Carter 166
Happy Endings 180
Chapter 12 Facing the Future 181
Spin Traps: Stopping Free-Radical Damage Before It Begins 181
Telomerase: Staying Forever Young 184
Resources 189
References 193
Index 197
About the Author 208
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First Chapter

Chapter 7
An Instant Anti-Aging Face-Lift

Go ahead. Sink your teeth into a delectable chocolate-fudge brownie. Plunge into a cool stream on a hot day. Pamper yourself with a long, sensuous massage. All three experiences promise one fantastic payoff--instant gratification. A surge of pleasure and satisfaction floods your senses seconds after you indulge yourself.

You can give your skin the same kind of quick satisfaction. In just about the time it takes you to finish a sinful dessert, DMAE complex can produce a visible and gratifying improvement. If you've shied away from so-called treatments because the very word conjures up visions of spending days carefully applying this and dipping in that until you finally see results, DMAE will change your mind. It's quick, it's easy, and it works.

DMAE is a great little acronym that's easier to say than the tongue twister dimethylaminoethanol. Mixed in a cocktail with other nutrients, combined with an antioxidant base, and applied topically, DMAE can quickly and dramatically improve the appearance of sagging skin. As an added bonus, DMAE boosts the effects of other antioxidants, resulting in increased smoothness, brightness, and line reduction.

What, exactly, is DMAE? Unlike the antioxidants I've discussed so far, DMAE is an antioxidant membrane stabilizer. Because of its unique structure, DMAE actually intersperses and becomes part of the cell plasma membrane. When this occurs, the membrane is more able to resist stress and therefore is stabilized. DMAE also gives some protection from free radicals--probably by preventing the other portions of the cell membrane from being attacked by free radicals--and therefore can act as an antioxidant. Thus, DMAE is an antioxidant membrane stabilizer. It prevents breakdown of the cell plasma membrane and the resulting production of arachidonic acid and a bunch of pro-inflammatory mediators. When mixed with other amino acids and nutrients, it has a dramatic firming effect on skin.

How DMAE Helps

One of the best places to find DMAE is in fish--nature's brain food. DMAE will increase the chemicals in the central nervous system that help us to think clearly. Millions of people take DMAE capsules simply to increase cognitive function.

Although DMAE has a very impressive record as a successful defense against aging, it is not traditionally thought of as an antioxidant. Conventional thinking aside, however, DMAE acts as an antioxidant because it helps stabilize cell membranes, protecting them from free-radical damage by helping cells to expel waste and hold on to valuable nutrients.

When this unusual nutrient complex is applied topically, not only does it work quickly--within minutes of application; it also continues to firm the skin over time. And it couldn't be safer. It's considered a food-grade substance, so you could actually eat it without doing yourself any harm, although I don't recommend that you try.

Putting DMAE to the Test

When I put DMAE to the test as part of a clinical study, I could clearly see a difference. Experimenting with 17 selected patients, I applied the DMAE lotion to half the face and neck of each patient and then waited 20 to 30 minutes. A dermatologist and cosmetic expert were then asked if they could tell the difference between the treated and untreated sides of the faces. The improvement in the treated skin could be seen clearly. The treated sides showed an increase in skin tone, producing tighter, more youthful-looking faces. The effect lasted for approximately 24 hours.

Later I determined that long-term use of DMAE could help to permanently increase the firmness of the skin. When I tested DMAE lotion on my patients for long periods of time, my patients and I saw incredible results. The first thing my patients reported was that they achieved a leaner look because the muscle tone in their faces improved. One female patient in her forties told me that several people she met asked what kind of diet she had been on. They thought she had lost thirty pounds. Her photographs told the same story: her face definitely looked firmer and more defined.

With prolonged use, some patients have even noticed that the tip of their noses got a bit of a lift owing to the increased muscle tone that DMAE brought about in their foreheads. Believe me, there is nothing that gives a face a more youthful look than raising the sagging tip of the nose.

Several study subjects brought another finding to my attention: their noses actually seemed thinner after repeated use of the DMAE lotion. One of the most exciting changes, however, occurred when we measured DMAE's effects on study participants' necks and jawlines. After only one application of the treatment, skin tone in the neck visibly improved. Within a few weeks of use, the jawline became more defined.

The most dramatic effect, however, was the natural lift that DMAE produced in the eyelids. All study participants reported a tighter, more toned appearance in the skin around the eyes after just a few days of use.

Chapter 9
Beauty from the Inside Out
The Anti-Inflammatory Diet

Don't panic! This chapter is not about losing weight. As a matter of fact, by the time you finish reading the next few pages, you'll no longer agonize about every calorie you consume; you'll celebrate the fact that you can fight the effects of aging with every meal. Even if you decide that you're not ready to try antioxidant-based creams or lotions, you can enjoy the benefits of increased antioxidant protection for your skin through your diet. The key is eating nutrition-packed, antioxidant-rich foods.

If you're the type of person who rushes over to the nearest department store anxious to try the latest skin-smoothing miracle cream, then it's time you started getting just as excited about your trips to the grocery store. Get started in the produce aisle. Picking and choosing is easy--just about every luscious, brightly colored fruit or vegetable that draws your eye can work wonders for your skin, so try one or two new foods each week. Next stop--the fresh fish and poultry counters. Eating high-quality protein will make your skin glow and give you healthier hair than ever, since your hair is 97 percent protein and needs a protein-rich diet to grow and thrive. But forgo the red meat because it is a pro-inflammatory food. Last, stroll over to the beverage aisle and fill your cart with mineral or spring water. Water is the one thing your entire body needs to perform the metabolic processes that keep you alive and keep your skin looking clear, bright, and beautiful. The inexpensive and relatively easy process of gradually adding these powerful foods to your diet will begin to take a few years off your appearance in no time.

In the next few pages, I will show you how to make your diet one of the most important parts of your skin care regimen. You can enhance the effects of my topical antioxidant program with a nutrition plan that promotes overall health. The best diet for good health and gorgeous skin is one made up of the freshest possible fruits and vegetables, combined with low-fat sources of protein, complex carbohydrates, and clean water. Also, remember that you'll never look your absolute best unless you eat right, get plenty of rest, and get at least a moderate amount of exercise.

The Quick Face Fix

What should you eat before a big event? Fish, fish, and more fish.

When my patients tell me they need to look absolutely fabulous for a big night, I recommend a topical dose of DMAE complex (of course) and suggest that they concentrate on eating certain foods for 48 hours before a special occasion. You can actually produce a healthier, smoother complexion with what you eat. The idea is to load up on plenty of non-insulin-promoting high-antioxidant foods, while hydrating your skin.

Here are some meal suggestions:


¥ Fresh fruit salad, with lots of berries

¥ Egg white omelet


¥ Hot or cold mixed vegetable medley: broccoli; green, red, and yellow bell peppers; cauliflower; and green beans. Season the vegetables with the fresh herbs of your choice. Cook with olive oil.

¥ 4 to 6 ounces of freshly broiled salmon

¥ A salad of leafy greens, with a little bit of olive oil and lemon juice

¥ Fresh melon such as cantaloupe or honeydew for dessert. WARNING: Do not eat your cantaloupe before your protein (fish). The protein slows the absorption of sugars from the cantaloupe into the bloodstream, so that it does not cause a spike in your blood sugar.

These foods are primarily non-insulin-promoting and rich in anti-inflammatory properties. Also drink 8 to 10 glasses of water each day.

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Sort by: Showing all of 11 Customer Reviews
  • Posted June 29, 2009

    Basic Perricone Book

    Unfortunately this book was published in 2000
    Skin Care had changed dramatically since then--his theories are not bad--but no longer the best--the book is simply outdated
    My error for not checking

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted August 27, 2006

    Good book, expensive products

    I thoroughly enjoyed reading this book. It was very educational and informative on proper diet,lifestyle and cosmetics to use to turn back the signs of aging.So I was excited to go to the perricone website to purchase some of his amazing products.But I was deeply disappointed to see the prices on the skin care line. I am used to spending a moderate amount of money on my skin care line, but there is no way that I can budget hundreds of dollars every few months to take care of my skin.

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted August 7, 2005

    The book works!

    This book really gets you on track. Yes, he does have his own line of cosmeceuticals, but the names are pretty generic. Follow his regiment and buy online. I found some of the same products at and they work just as well. Dr. Perricone is great at what he does. You need the book to do it right.

    1 out of 1 people found this review helpful.

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  • Posted December 29, 2009

    I Also Recommend:

    Good Companion book to "7 Secrets to Beauty, Health, and Longevity"

    This book focuses on anti-aging skin care through supplements, food choices, and life style changes. It is a great companion to Dr. Perricone's 7 Secrets... book. Although it can be used alone if anti-aging is your specific area of interest.

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  • Anonymous

    Posted July 11, 2009

    Best kept secret

    A must read for all. If you want to know on cellular level what is going on in your cells, including your skin cells! as they age, then this is a quick but scientific read. I found this book in my mothers library in Spain and I knew I had found a treasure. I will buy all the copies Barnes & Nobles has and give them to people I care about.

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted March 20, 2002

    I'm so excited

    I am so excited that he writes about how to look younger without surgery. Although most people would be turned off by the products that he recommends due to their cost, I found that they are all available through BeautiControl for only $189. This is really fascinating to find that the ingredients can be found in the products that I am already using.

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  • Anonymous

    Posted February 3, 2002

    He just so happens to have his own line of skin care...Sound fishy??? Read on!

    When you first begin to read this book, you are so glad to hear an MD give info on nutrition, supplements, etc. and from one who actually believes in 'prevention.' You're so glad he talks about the unnecessary 'expense' of cosmetic surgery and the dangers of it. You start to really trust the guy until you find out that the products he so believes will make you look younger, are only found at Saks, Nordstroms, and a few other select salons- and guess whose name is on the label??? For a mere 450 dollars, you too can have a 3 month supply of the author's serums, lotions, etc.!! The good news-you can actually buy most of his suggested ingrediants in potions and creams from your local health food store, drug store, or online pharmacy.

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted January 14, 2002

    Great book if you follow exact directions!

    This is a book which brings home the saying 'you are what you eat'. I tried the 3 day diet and personally did not notice too much of a difference on my face but I FELT great! The foods suggested are all low on the glycemic scale and therefore not fattening. Since buying the book I have emptied out my cupboard of 'bad' foods once and for all and am really encouraged to eat well not only for my skin, but for overall health. Supposedly the charts on the skin are for 'lay people'. Without a chemistry background I found some of them difficult to understand...but I will take Dr. Perricone's word for it since he looks so great at the age of 53!

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  • Anonymous

    Posted November 2, 2000

    This really works!

    As a baby boomer and professional, I am somewhat of a skeptic, however after seeing the amazing results of the 3 day Wrinkle Cure diet on Good Morning America I decided to buy the book. The Wrinkle Cure is chock full of breakthrough information focussing on diet and the role anti-oxidants. When they are taken internally and applied externally they work synergistically to cause dramatic changes in wrinkles and sagging skin. Dr. Perricone also explains what foods increase skin firmness and what skins cause premature aging. I am very grateful to find a program based on genuine science that appears to be working right before my eyes.

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  • Anonymous

    Posted August 17, 2000

    Infomercial in book form

    I found this book to be quite like an infomercial. A lot of what was written leads to the fact that the Dr. sells products about which he writes. I went to his site and the recommended products would cost me approximately $430.00 for an estimated 3 month supply. He does, however, give a few token alternatives to his products.

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  • Anonymous

    Posted April 8, 2010

    No text was provided for this review.

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