X-Ray Crystallography of Biomacromolecules: A Practical Guide / Edition 1

X-Ray Crystallography of Biomacromolecules: A Practical Guide / Edition 1

by Albrecht Messerschmidt, Messerschmidt
     
 

ISBN-10: 3527313966

ISBN-13: 9783527313969

Pub. Date: 02/02/2007

Publisher: Wiley

Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from this extremely

Overview

Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from this extremely clearly written book.
Part A covers the theoretical basis and such experimental techniques as principles of x-ray diffraction, solutions for the phase problem and time-resolved x-ray crystallography. Part B includes case studies for different kinds of x-ray crystal structure determination, such as the MIRAS and MAD techniques, molecular replacement, and the difference Fourier technique.

Product Details

ISBN-13:
9783527313969
Publisher:
Wiley
Publication date:
02/02/2007
Pages:
318
Product dimensions:
6.93(w) x 9.67(h) x 0.83(d)

Table of Contents

PART A THEORETICAL BASIS AND EXPERIMENTAL TECHNIQUES
Introduction
Techniques
Principles of X-ray Diffraction by a Crystal
Methods for Solving the Phase Problem
Model Building and Refinement
Time-resolved X-ray Crystallography

PART B CASE STUDIES FOR DIFFERENT KINDS OF X-RAY CRYSTAL STRUCTURE DETERMINATION OF BIOMACROMOLECULES
Space Group Determination and Data Reduction
Phase Determination by MIRAS Technique
Phase Determination by MAD Technique
Phase Determination by Molecular Replacement
Difference Fourier Technique
Map Improvement by NCS Averaging and other Methods
Automated Model Building
Structure Validation and PDB-Submission

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