X-Ray Crystallography of Biomacromolecules: A Practical Guide / Edition 1

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Overview

Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from this extremely clearly written book.
Part A covers the theoretical basis and such experimental techniques as principles of x-ray diffraction, solutions for the phase problem and time-resolved x-ray crystallography. Part B includes case studies for different kinds of x-ray crystal structure determination, such as the MIRAS and MAD techniques, molecular replacement, and the difference Fourier technique.

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Editorial Reviews

From the Publisher
"This is clearly going to be a very useful book for students and researchers coming from across all the relevant disciplines." (Crystallography Reviews, July 2008)

"…this book is reasonably well organized and covers all the relevant theory and much of the practical applications of the field." (Journal of the American Chemical Association, August 6, 2008)

I would highly recommend this book to someone who is thinking about or already using X-ray crystallography. (The Yale Journal of Biology and Medicine, March 2008)

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Product Details

  • ISBN-13: 9783527313969
  • Publisher: Wiley
  • Publication date: 2/2/2007
  • Edition number: 1
  • Pages: 318
  • Product dimensions: 6.93 (w) x 9.67 (h) x 0.83 (d)

Meet the Author

Professor Dr. Albrecht Messerschmidt is group leader at the Max Planck Institute for Biochemistry, Marinsried, Germany.
His main reserach interest is in the determination of X-ray structures of metalloproteins and -enzymes, PLP-dependent enzymes, CoA-transferases and other proteins. His group is part of the department of X-ray structure determination of proteins headed by nobel laureate Robert Huber.

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Table of Contents

PART A THEORETICAL BASIS AND EXPERIMENTAL TECHNIQUES
Introduction
Techniques
Principles of X-ray Diffraction by a Crystal
Methods for Solving the Phase Problem
Model Building and Refinement
Time-resolved X-ray Crystallography

PART B CASE STUDIES FOR DIFFERENT KINDS OF X-RAY CRYSTAL STRUCTURE DETERMINATION OF BIOMACROMOLECULES
Space Group Determination and Data Reduction
Phase Determination by MIRAS Technique
Phase Determination by MAD Technique
Phase Determination by Molecular Replacement
Difference Fourier Technique
Map Improvement by NCS Averaging and other Methods
Automated Model Building
Structure Validation and PDB-Submission

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