Xenobiotics and Food-Producing Animals: Metabolism and Residues

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Discusses the metabolism and fate of xenobiotic compounds, such as veterinary drugs, agrochemicals, and other products to which food-producing animals are exposed. Describes state-of-the-art techniques for experimental studies of xenobiotic compounds in ruminants, poultry, and aquatic species, including study design to meet specific regulatory requirements. Also addresses the fate of specific products such as prilimycin, albenazole tilmicosin, ametryn, sulfonamides, invermectin and avervectin, luprostiol, and ...
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Overview


Discusses the metabolism and fate of xenobiotic compounds, such as veterinary drugs, agrochemicals, and other products to which food-producing animals are exposed. Describes state-of-the-art techniques for experimental studies of xenobiotic compounds in ruminants, poultry, and aquatic species, including study design to meet specific regulatory requirements. Also addresses the fate of specific products such as prilimycin, albenazole tilmicosin, ametryn, sulfonamides, invermectin and avervectin, luprostiol, and the repartitioning agent ractopamine. Offers an introduction to the use and regulation of veterinary drugs in the United States and Europe.
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Editorial Reviews

Booknews
Discusses the metabolism and fate of a number of specific xenobiotic compounds to which food-producing animals are exposed as veterinary drugs, agrochemicals, and other products. Also describes the techniques for experimental studies on ruminants, poultry, and aquatic species, including experiments designed to meet specific regulatory requirements. The 16 papers are from a symposium at the American Chemical Society national meeting in New York, August 1991. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780841224728
  • Publisher: American Chemical Society
  • Publication date: 5/5/1992
  • Series: ACS Symposium Series
  • Pages: 255
  • Product dimensions: 6.00 (w) x 9.00 (h) x 1.00 (d)

Meet the Author

Shell Research Limited

Huntingdon Research Centre

U.S. Department of Agriculture

Hazelton Laboratories

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Table of Contents

Preface
Veterinary Drugs: Use and Regulation
1 Uses and Regulation of Veterinary Drugs: Introduction 2
2 Use of Xenobiotics in Food-Producing Animals in the United States: Regulatory Aspects 17
3 Veterinary Medicines: Regulation in Europe and the Importance of Pharmacokinetic Studies 26
4 Design and Conduct of Studies To Meet Residue Chemistry Requirements: Residue Depletion and Metabolism of Flunixin in Cattle 37
5 Semduramicin in the Chicken: Tissue Residue Depletion Studies 49
Methodology of Xenobiotic Metabolism
6 In Vitro Models for Biotransformation and Toxicity Studies in Farm Animals: Furazolidone and Isolated Pig Hepatocytes 72
7 Dermal Absorption and Metabolism of Xenobiotics in Food-Producing Animals 88
8 Drug Pharmacokinetics and Metabolism in Food-Producing Fish and Crustaceans: Methods and Examples 98
Metabolism and Disposition
9 Pirlimycin in the Dairy Cow: Metabolism and Residue Studies
10 Albendazole in Cattle Administered via a Sustained-Release "Captec" Device: Pharmacokinetics and Tissue Residues 148
11 Tilmicosin in Cattle: Metabolism and Tissue Residues 158
12 Ametryn in Rats, Lactating Goats, and Laying Hens: Metabolic Fate 168
13 Sulfonamide Drug in Lactating Dairy Cows: Novel Metabolism 190
14 Ivermectin and Abamectin Metabolism: Differences and Similarities 203
15 Luprostiol in Dairy Cows: Residue Depletion and Metabolism 217
16 Ractopamine Hydrochloride, a Phenethanolamine Repartitioning Agent: Metabolism and Tissue Residues 234
Author Index 246
Affiliation Index 246
Subject Index 247
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