Zebrafish Models of Neurodegenerative Disorders

by Ebru Emekli-Alturfan (Editor)

Overview

Advancing our understanding of neurodegenerative diseases demands innovative tools and approaches. Zebrafish Models in Neurodegenerative Disorders offers a comprehensive examination of zebrafish as a translational model for studying the molecular and cellular mechanisms of diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Beginning with the first section informing about the basic molecular mechanisms of neurodegenerative disorders, biomarkers, and therapeutic approaches, the book continues with the detailed exploration of zebrafish physiology, genetics, and behavioural phenotypes as they pertain to neurodegenerative pathologies; insight into cutting-edge technologies, including CRISPR/Cas9 genome editing; and in-depth analysis of zebrafish models, highlighting their strengths in modelling disease progression and therapeutic testing.

Product Details

ISBN-13:	9781032660462
Publisher:	CRC Press
Publication date:	09/08/2025
Series:	Neuroscience of Neurodegenerative Disease
Pages:	380
Product dimensions:	8.25(w) x 11.00(h) x (d)

About the Author

Dr. Ebru Emekli-Alturfan received her PhD in biochemistry from the University of Marmara in 2006 and was appointed as a professor in the Faculty of Dentistry at Marmara University, specifically within the Department of Basic Medical Sciences in 2016. Ebru Emekli-Alturfan leads a research group using Zebrafish as a model organism to investigate molecular mechanisms of neurodegeneration. Their research encompasses neurodegeneration, neurodevelopment, and its molecular regulation in vertebrate development. They use zebrafish as a main model system. To investigate the genetic foundation of human diseases, they work together with colleagues both within the Medical and Dental School and internationally to develop and implement in vivo models. Besides leading a research group, Ebru Emekli-Alturfan teaches medical biochemistry courses at Marmara University's Faculty of Dentistry and Institute of Health Sciences.

Table of Contents

Chapter 1: Main Molecular Mechanisms of Neurodegenerative Disorders. Chapter 2: Molecular Markers of Neurodegenerative Disorders. Chapter 3: Pharmacotherapy of Neurodegenerative Diseases. Chapter 4: Zebrafish Model of Neurodegenerative Disorders. Chapter 5: Zebrafish as a Model Organism for the Investigation of Neurodegenerative Aspects of Autism Spectrum Disorders. Chapter 6: Neurogenesis in the Zebrafish Olfactory Epithelium in Response to Nuerotoxicity and Injury. Chapter 7: Epigenetic Regulations during Neurogenesis in Zebrafish. Chapter 8: Proteomic Approaches on Neurodegenerative Disease Models in Zebrafish. Chapter 9: Zebrafish as a Model for Functional Analyses of Alzheimer's Disease-Related Genes and Drug Development. Chapter 10: Perfluorinated Chemicals, Zebrafish, and Neurodegenerative Disorders.Chapter 11: Effect of Myelination of Neurodegeneration and Neurodegenerative Diseases in the Zebrafish Model.Chapter 12: Zebrafish as a Model Organism to Evaluate the Neurotoxic Effects of Endocrine Disruptive Chemicals.  Chapter 13: Using Zebrafish to Explore the Brain-Gut Axis in Neurodegenerative Disorders. Chapter 14: Glyphosate Exposure and Neurological Outcomes in Zebrafish. Chapter 15: Zebrafish Model Organism to Investigate Pain in Neurodegenerative Diseases.  Chapter 16: Neurodegenerative Disease Modelling with CRISPR/CAS Systems in Zebrafish. Chapter 17: Zebrafish Genetic Models of Alzheimer's Disease. 
Chapter 18: Neurodegenerative Effects of Boron and Other Elements on Zebrafish and Zebrafish Embryos.  Chapter 19: Effects of Microplastics and Nano-plastics on Neurodevelopment and Neurodegeneration in Zebrafish. Chapter 20: Investigation of the Effects of Vitamins on Neurodegenerative Diseases using Zebrafish as a Model Organism.Chapter 21: Usability of Zebrafish as a Model Organism to Investigate the Relationship between Breast Milk and Neurodegeneration.  Chapter 22: Antimicrobial Agents in Mouthwashes: Unveiling Neurotoxic and Neurodegenerative Impacts through Zebrafish Models.