The Black Widow, the most prolific and elusive American female serial killer in the 21st century, crisscrosses the country to feed her desires and appetite. Prim librarian by day, Myra James haunts bars, casinos and hotels for unsuspecting male victims as the Black Widow. Myra James successfully evaded the FBI on her trail of slayings across multiple states. Choosing Las Vegas to be anonymous amidst the burgeoning growth, she meets her match in Det. Dan Stroberg of Metro. Her unique and particularly gruesome style of seduction and murder shocks the hard-boiled detective, who faces nearly insurmountable challenges to stop her.