Pub. Date:
Springer Netherlands
25 Years of p53 Research / Edition 1

25 Years of p53 Research / Edition 1

by Pierre Hainaut, Klas G. Wiman


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Product Details

ISBN-13: 9781402029202
Publisher: Springer Netherlands
Publication date: 06/01/2005
Edition description: 2005
Pages: 446
Product dimensions: 6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

Foreword to The Paperback Edition     ix
The First Twenty-Five Years of p53 Research   Harlan Robins   Gabriela Alexe   Sandra Harris   A. J. Levine     1
Regulation of p53 DNA Binding   Kristine McKinney   Carol Prives     27
20 Years of DNA Damage Signaling to p53   Kevin G. McLure   Michael B. Kastan     53
Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX   Geoffrey M. Wahl   Jayne M. Stommel   Kurt Krummel   Mark Wade     73
Regulation of the p53 Response by Cellular Growth and Survival Factors   Lauren Brown   Samuel Benchimol     115
p53, Cell Cycle Arrest and Apoptosis   Shulin Wang   Wafik S. El-Deiry     141
p53 Has a Direct Pro-apoptotic Action at the Mitochondria   Ute M. Moll     165
Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor   Lawrence A. Donehower   Dora Bocangel   Melissa Dumble   Guillermina Lozano     183
p53, p63, and p73: Internecine Relations?   Frank McKeon   Annie Yang     209
p73, p63 and Mutant p53: Members of Protein Complexs Floating in Cancer Cells   Olimpia Monti   Alexander Damalas   Sabrina Strano   Giovanni Blandino     223
p53: Gatekeeper, Caretaker or Both?   Carlos P. Rubbi   Jo Milner     233
Analysis of p53 Gene Alterations in Cancer: A Critical View   Thierry Soussi     255
Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection   Hong Shi   Florence Le Calvez   Magali Olivier   Pierre Hainaut     293
Prognostic and Predictive Value of TP53 Mutations in Human Cancer   Magali Olivier   Pierre Hainaut   Anne-Lise Borresen-Dale     321
p53 Links Tumor Development to Cancer Therapy   Michael T. Hemann   Scott W. Lowe     339
Novel p53-Based Therapies: Strategies and Future Prospects   Sonia Lain   David Lane     353
Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue   Andreas C. Joerger   Assaf Friedler   Alan R. Fersht     377
Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy   Galina Selivanova   Vladimir J.N. Bykov   Klas G. Wiman     399
Novel Approaches to p53-Based Therapy: ONYX-015   Frank McCormick      421
p53 as Seen by an Outsider   George Klein     431
Index     439

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