A mathematical modeling framework to simulate and analyze cell type transitions

A mathematical modeling framework to simulate and analyze cell type transitions

by Daniella Schittler

Paperback

$58.00
Usually ships within 6 days

Overview

The quantitative understanding of changes in cell types, referred to as cell type transitions, is fundamental to advance fields such as stem cell research, immunology, and cancer therapies. This thesis provides a mathematical modeling framework to simulate and analyze cell type transitions. The novel methodological approaches and models presented here address diverse levels which are essential in this context: Gene regulatory network models represent the cell type-determining gene expression dynamics. Here, a novel construction method for gene regulatory network models is introduced, which allows to transfer results from generic low-dimensional to realistic high-dimensional gene regulatory network models.For populations of cells, a generalized model class is proposed that accounts for multiple cell types, division numbers, and the full label distribution. Analysis and solution methods are presented for this new model class, which cover common cell population experiments and allow to exploit the full information from data. The modeling and analysis methods presented here connect formerly isolated approaches, and thereby contribute to a holistic framework for the quantitative understanding of cell type transitions.

Product Details

ISBN-13: 9783832539351
Publisher: Logos Verlag
Publication date: 03/20/2015
Pages: 189
Product dimensions: 6.00(w) x 1.25(h) x 9.00(d)

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews