Table of Contents
Contributors vii
Preface xi
Section I Foundations for Understanding Antiviral Therapies in HCV
1 HCV Replication 3Michael R. Beard
2 Hepatitis C Virus Genotypes 12Scott A. Read and Mark W. Douglas
3 Immune Responses to HCV: Implications for Therapy 17David G. Bowen
4 Mechanisms of Action of Antiviral Drugs: The Interferons 25Edmund Tse and Michael R. Beard
5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs 36Fred Poordad and Grace M. Chee
6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors 43Lotte Coelmont Leen Delang Mathy Froeyen Piet Herdewijn and Johan Neyts
7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors 53Laurent Chatel-Chaix Martin Baril and Daniel Lamarre
8 Measuring Antiviral Responses 60Jean-Michel Pawlotsky and Stephane Chevaliez
Section II Efficacy and Clinical Use of Antiviral Therapies
9 Genotype 1: Standard Treatment 67Rebekah G. Gross and Ira M. Jacobson
10 Individually Tailored Treatment Strategies in Treatment-naíve Chronic Hepatitis C Genotype 1 Patients 74Johannes Wiegand and Thomas Berg
11 Genotype 1 Relapsers and Non-responders 84Salvatore Petta and Antonio Craxì
12 Standard Therapy for Genotypes 2/3 90Kenneth Yan and Amany Zekry
13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3 97Alessandra Mangia Leonardo Mottola and Angelo Andriulli
14 Genotypes 2 and 3 Relapse and Non-response 104Stella Martinez Jose Maria Sanchez-Tapias and Xavier Forns
15 Hepatitis C Genotype 4 Therapy: Progress and Challenges 113Sanaa M. Kamal
16 Antivirals in Acute Hepatitis C 127Heiner Wedemeyer
17 Antivirals in Cirrhosis and Portal Hypertension 132Diarmuid S. Manning and Nezam H. Afdhal
18 Treatment of Recurrent Hepatitis C Following Liver Transplantation 140Ed Gane
19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations 150Benjamin Terrier and Patrice Cacoub
20 Cytopenias: How they Limit Therapy and Potential Correction 160Mitchell L. Shiffman
21 The Problem of Insulin Resistance and its Effect on Therapy 169Venessa Pattullo and Jacob George
22 HIV and Hepatitis C Co-infection 177Gail V. Matthews and Gregory J. Dore
23 HCV and Racial Differences 185Andrew J. Muir
24 HCV and the Pediatric Population 190Kathleen B. Schwarz
25 New Horizons: IL28 Direct-acting Antiviral Therapy for HCV 196Alexander J. Thompson John G. McHutchison and Geoffrey W. McCaughan
Index 215