Advances in Clinical Chemistry

Advances in Clinical Chemistry

by Gregory S. Makowski (Editor)

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Product Details

ISBN-13: 9780128152034
Publisher: Elsevier Science
Publication date: 11/09/2018
Series: Advances in Clinical Chemistry Series , #87
Pages: 212
Product dimensions: 6.00(w) x 9.00(h) x (d)

About the Author

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Table of Contents


Contributors     ix
Preface     xi
Caspases in Myocardial Infarction   Nina Zidar   Jeruc Jera   Jerse Maja   Stajer Dusan
Abstract     1
Introduction     2
Apoptosis and the Heart     3
Caspases     3
Activation of Caspases     4
Activation of Caspases in the Heart     5
Functional Significance of Caspases     6
Caspases for Detection of Apoptosis     9
Apoptosis and Caspases in MI     11
Apoptosis of Cardiomyocytes in Ventricular Remodeling After MI     14
Apoptosis of Other Cell Types in the Evolution of Fibrous Scar     15
Anti-Caspase Treatment     18
Conclusion     23
References     23
Deamidated Gliadin Peptides as Targets for Celiac Disease-Specific Antibodies   Thomas Mothes
Abstract     36
Introduction     36
Prolamins as Cereal Storage Proteins     37
Pathogenesis of CD     38
Serological Diagnosis of CD     42
Gliadin Antibodies of CD Patients Recognize Deamidated Gliadin     45
Enhanced Diagnostic Potential of Glutamine-Glutamic Acid Substituted Gliadin-Analogous Peptides     47
Does Epitope Specificity of Gliadin Antibodies of CD Patients Mirror Substrate Specificity of tTG?     49
Relation Between B- and T-Cell Epitopes of Gliadin     51
Conclusions     52
References     53
Urokinase Receptor Variants in Tissue and Body Fluids   Gunilla Hoyer-Hansen   Ida Katrine Lund
Abstract     66
Introduction     67
Monoclonal Antibodies to uPAR     77
Immunoassays for the Quantification of uPAR     79
uPAR in Cancer     82
Other Diseases     91
Conclusions and Perspectives     91
References     93
Proteomics in Cancer   M. A. Reymond   W. Schlegel
Abstract     104
Introduction     104
Sampling for Proteomic Analysis     106
Proteomic Technologies Used in Cancer Proteomics     110
Proteomic Applications in Cancer     114
What Has Been Achieved in Cancer Proteomics?     127
Conclusion     133
References     134
Paraneoplastic Neurological Syndromes and Onconeural Antibodies: Clinical and Immunological Aspects   Anette Storstein   Christian A. Vedeler
Abstract     144
Introduction      144
Onconeural Antigens     148
Paraneoplastic Syndromes of the CNS     149
PNS of the Peripheral Nervous System     155
Paraneoplastic Nervous System Syndromes of the Neuromuscular Junction     159
Diagnosis of Paraneoplastic Nervous System Syndromes     159
Pathogenesis of Paraneoplastic Nervous System Syndromes     165
Therapy for Paraneoplastic Nervous System Syndromes     170
Future Aspects     172
References     172
Pathophysiological Mechanisms of Angiogenesis   David A. Walsh
Abstract     188
Introduction     189
Measuring the Angiogenic Process     191
Endothelial Cells and the Initiation of Angiogenesis     193
Differential Angiogenic Pathways     198
Impact of the Vessel's Environment on Angiogenesis     204
Angiogenesis Biomarkers for Assessing Human Disease     205
Therapeutic Targeting of Angiogenesis     210
Conclusion     211
References     212
Bikunin (Urinary Trypsin Inhibitor): Structure, Biological Relevance, and Measurement   Michael J. Pugia   Roland Valdes, Jr.   Saeed A. Jortani
Abstract     224
Introduction      225
Roles in Biological Processes     230
Diagnostic Testing     233
Pathophysiology of Bik     235
Summary     240
References     240
Gene Expression Assays   Janine Kirby   Paul R. Heath   Pamela J. Shaw   Freddie C. Hamdy
Abstract     248
Introduction     248
The Technology     250
Gene Expression Assays in Cancer     256
Applications of Arrays to Neurological Disorders     265
Application of Microarrays to Neuropsychiatric Disorders     277
Future Advances     281
References     282
Index     293

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