ISBN-10:
1118014286
ISBN-13:
9781118014288
Pub. Date:
11/15/2011
Publisher:
Wiley
Advances in Enzymology and Related Areas of Molecular Biology / Edition 1

Advances in Enzymology and Related Areas of Molecular Biology / Edition 1

by Eric J. Toone

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Product Details

ISBN-13: 9781118014288
Publisher: Wiley
Publication date: 11/15/2011
Series: Advances in Enzymology and Related Areas of Molecular Biology Series , #240
Pages: 568
Product dimensions: 6.10(w) x 9.10(h) x 1.40(d)

About the Author

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

Table of Contents

Contributors vii

Preface ix

Structure and Regulation of Type 2 Transglutaminase in Relationto Its Physiological Functions and Pathological Roles 1
Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and MartinGriffin

Physiopathological Roles of Human Transglutaminase 2 47
Vittorio Gentile

Transglutaminase in Epidermis and Neurological Disease or WhatMakes a Good Cross-Linking Substrate 97
Guylaine Hoffner, Amandine VanHoutteghem, William Andre, andPhilippe Djian

Transglutaminase 2: A New Paradigm for NF-B Involvement inDisease 161
Soo-Youl Kim

Transglutaminase 2 At the Crossroads between Cell Death andSurvival 197
Mauro Piacentini, Manuela D’Eletto, Laura Falasca, MariaGrazia Farrace, and Carlo Rodolfo

Tissue Transglutaminase and Its Role in Human Cancer Progression247
Bo Li, Richard A. Cerione, and Marc Antonyak

Transglutaminase 2 Dysfunctions in the Development of AutoimmuneDisorders: Celiac Disease and TG2−/−Mouse 295
Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and LaszloFesus

Effects and Analysis of Transglutamination on ProteinAggregation and Clearance in NeurodegenerativeDiseases 347
Zoltan Nemes

Transglutaminase-Mediated Remodeling of the Human ErythrocyteMembrane Skeleton: Relevance for Erythrocyte Diseases withShortened Cell Lifespan 385
Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE,Oksana Lockridge, and Athar H. Chishti

Irreversible Inhibitors of TissueTransglutaminase 415
Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani,Olivier Leogane, and Christophe Pardin

Methionine Adenosyltransferase (S-AdenosylmethionineSynthetase) 449
María A. Pajares and George D. Markham

Index 523

What People are Saying About This

From the Publisher

"With its discussion of current concepts of the biochemical basis of antibiotic resistance and its impact on modern medicine, this book will appeal to students, researchers, scientists, and clinicians interested in the areas of enzymology and mechanism of bacterial resistance." (Doody's, 26 August 2011)

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