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Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirm our commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. This volume of Advances in Genetics contains articles on: Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila, The Neurospora crassa Circadian Clock, Involvement of Homologous Recombination in Carcinogenesis, Mutational Analysis of the Ribosome, Application of Genomics to Molecular Breeding of Wheat and Barley.
About the Author
School of Medicine, University of California at San Diego, USA
Dr. Jay Dunlap works at the Geisel School of Medicine at Dartmouth.
Dr. Stephen Goodwin works at the University of Oxford.
Table of Contents
Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila Pierre Hutter 1
Experimental Approaches 5
Influences of Rab9D on Viability of Hybrids Between D. melanogaster and Its Sibling Species 5
Predictions of Functions for 6paRAB9 Proteins 14
General Considerations 16
The Neurospora crassa Circadian Clock Christian Heintzen Yi Liu 25
Neurospora as a Circadian Model System 27
The Molecular Machinery of the Neurospora Circadian Oscillator 28
Temporal Input from the Environment 42
Temporal Output from the Oscillator 54
FRQ-Less Oscillators 56
Involvement of Homologous Recombination in Carcinogenesis Ramune Reliene Alexander J. R. Bishop Robert H. Schiestl 67
HR Involvement in DNA Repair 69
HR and Carcinogenesis 71
Other Diseases Attributable to HR 75
Carcinogen-Induced HR inExperimental Systems 76
Mutational Analysis of the Ribosome Kathleen L. Triman 89
Mutational Analysis of 16S rRNA Structure and Function 91
Mutational Analysis of 23S rRNA Structure and Function 97
Mutational Analysis of Ribosomal Protein Structure and Function 103
Mutational Analysis of Ribosomal Factor Structure and Function 106
Concluding Remarks 108
Application of Genomics to Molecular Breeding of Wheat and Barley Rajeev K. Varshney Peter Langridge Andreas Graner 121
Molecular Markers and Marker-Assisted Breeding 123
Genomic Resources and Approaches 131
Comparative Genomics 137
Exploitation of Natural Variation and Allelic Diversity 138
Concluding Remarks 143