Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo / Edition 1

by David Raeburn, Mark A. Giembycz

Overview

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Product Details

ISBN-13:	9783034898638
Publisher:	Birkhäuser Basel
Publication date:	10/01/2011
Series:	Respiratory Pharmacology and Pharmacotherapy
Edition description:	Softcover reprint of the original 1st ed. 1996
Pages:	300
Product dimensions:	6.69(w) x 9.61(h) x 0.02(d)

Table of Contents

1. Measurement of Airways Smooth Muscle Responsiveness in Animals.- 2. Methods of Drug Administration to the Lung in Animals.- 3. PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs.- 4. Antigen-Induced Bronchial Hyperreactivity in Rats.- 5. Ozone-Induced Bronchial Hyperreactivity.- 6. Virus-Induced Bronchial Hyperreactivity.- 7. The Rabbit Model of Asthma and the Late Asthmatic Response.- 8. The Sheep as a Model of the Late Asthmatic Response.- 9. Primate Models of Asthma.- 10. The Sensitized Pig Model of Asthma.- 11. Transgenic Animals and the Modelling of Asthma.

Editorial Reviews

For researchers using animals to investigate human asthma, explains physiological and pharmacological process in the lung in vivo, and reviews the animal models available for studying the bronchospasm and inflammation associated with human asthma. Also discusses such methodological aspects as administering drugs to animal airways and the mechanics of assessing lung function. Also considers the use of genetically altered animals as research models. The sixth volume in the Airways Smooth Muscle sub- series. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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