Pub. Date:
Cambridge University Press
Allostasis, Homeostasis, and the Costs of Physiological Adaptation

Allostasis, Homeostasis, and the Costs of Physiological Adaptation

by Jay Schulkin


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Allostasis, Homeostasis, and the Costs of Physiological Adaptation

There are many books on homeostasis, so the focus here is on allostasis as an additional explanation for the diverse forms of adaptation to changing circumstances that animals exhibit. Not even the contributors here agree totally on a definition, but do agree that it emphasizes adaptive changes and a diverse range of physiological and behavioral options that emerged with central nervous system involvement in peripheral physiological regulation, and the breakdown of regulatory systems when pushed beyond adaptation. Researchers mostly from psychology, but also a number of other disciplines review recent literature with the hope of stimulating colleagues to investigate the mechanisms that underlie physiological and behavioral adaptation in the regulation of the internal milieu. Annotation ©2004 Book News, Inc., Portland, OR

Product Details

ISBN-13: 9780521811415
Publisher: Cambridge University Press
Publication date: 09/28/2004
Edition description: New Edition
Pages: 384
Product dimensions: 6.97(w) x 9.96(h) x 1.10(d)

Table of Contents

1Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics17
2Protective and Damaging Effects of the Mediators of Stress and Adaptation: Allostasis and Allostatic Load65
3Merging of the Homeostat Theory with the Concept of Allostatic Load99
4Operationalizing Allostatic Load113
5Drug Addiction and Allostasis150
6Adaptive Fear, Allostasis, and the Pathology of Anxiety and Depression164
7A Chronobiological Perspective on Allostasis and Its Application to Shift Work228
8Allostatic Load and Life Cycles: Implications for Neuroendocrine Control Mechanisms302
Commentary: Viability as Opposed to Stability: An Evolutionary Perspective on Physiological Regulation343

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