ISBN-10:
0387773738
ISBN-13:
9780387773735
Pub. Date:
01/23/2008
Publisher:
Springer New York
Alternative Splicing in the Postgenomic Era / Edition 1

Alternative Splicing in the Postgenomic Era / Edition 1

by Benjamin J. Blencowe, Brenton R. Graveley

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Overview

Alternative Splicing in the Postgenomic Era / Edition 1

Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.

Product Details

ISBN-13: 9780387773735
Publisher: Springer New York
Publication date: 01/23/2008
Series: Advances in Experimental Medicine and Biology , #623
Edition description: 2007
Pages: 228
Product dimensions: 6.60(w) x 10.20(h) x 0.60(d)
Age Range: 3 Months

Table of Contents

CONTENTS FOREWORD......................................................................................................... v PREFACE.............................................................................................................. ix ABOUT THE EDITOR S.................................................................................... xiii PARTICI PANTS.................................................................................................. xv 1. Nuclear Organization and Splicing Control..................... 1 Maria Carmo-Fonseca and Célia Carvalho Abstract................................................................................................................................. 1 Splicing and the Nucleus...................................................................................................... 1 Compartmentalization of Splicing and Splicing Factors.................................................. 3 Compartmentalization of Splicing Factors and Splicing Regulation............................... 8 Perspectives.......................................................................................................................... 9 2. Spliceosome Assembly and Composition............................... 14 Arianne J. Matlin and Melissa J. Moore Abstract............................................................................................................................... 14 Introduction........................................................................................................................ 14 Composition and Structure................................................................................................ 14 In Vitro Spliceosome Assembly.......................................................................................... 15 Product Release and snRNPRecycling............................................................................. 24 Interactions at the Ends of Transcripts That Promote Spliceosome Assembly................................................................................................ 24 The Holospliceosome Hypothesis...................................................................................... 24 Insights from In Vivo Analysis of Spliceosome Assembly............................................... 25 Commitment to Particular Splice Sites............................................................................. 26 Proofreading....................................................................................................................... 26 Final Comments.................................................................................................................. 28 3. Relating Alternative Splicing to Proteome Complexity and Genome Evolution.................................. 36 Yi Xing and Christopher Lee Abstract............................................................................................................................... 36 Alternative Splicing and Proteomic Complexity.............................................................. 36 Alternative Splicing of Protein Domains and Functional Sites...................................... 37 Alternative Splicing and Protein Structure...................................................................... 39 Alternative Splicing and Genome Evolution.................................................................... 40 Alternative Splicing and Amino Acid Mutation Selection Pressure............................... 43 Alternative Splicing and RNA Selection Pressure........................................................... 43 Connecting RNA Selection Pressure to Real Splicing

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