Alzheimer's and Parkinson's Diseases: Strategies for Research and Development available in Hardcover
- Pub. Date:
- Springer US
This book is the outcome of an international conference, held at the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985. This was the 30th in a series of the annual OHOLO Conferences, sponsored by the Israel Institute for Biological Research. Participants in this Conference consisted of scientists from four teen countries; represented a broad spectrum of research interests; and included a well-balanced representation from academia, clinical institutions and pharmaceutical industry. The book includes talks, poster sessions, and a comprehensive general discussion, all from the proceedings of this conference. In the interest of assuring a rapid publication of the novel infor mation reviewed, this book has been prepared in camera-ready format. We are cognizant of the fact that several typographical errors may exist in the text, and that there are variations in style and typeface of the var ious chapters. This, we felt, was a reasonable compromise for the sake of speed and efficient transmission of valuable scientific information. No body is perfect . •••• The success of the conference, and hence the quality of this book are attributable to the extensive efforts of a large number of extremely capable individuals. These include members of the Scientific Organizing Committee, and the Technical staff of the OHOLO Organization. Of course, the conference could not have succeeded without the high quality of the presentations, and the enthusiastic participation of the contributing scientists.
Table of ContentsWelcoming Address.- Alzheimer’S And Parkinson’S Disease: Anatomical, Pathological And Biochemical Aspects.- Cholinergic Systems in the Brain and Spinal Cord: Anatomic Organization and Overview of Functions.- Histopathology of the Basal Forebrain and Its Targets in Alzheimer Dementia..- Clinical, Pathological and Biochemical Aspects of Alzheimer’s Disease.- Molecular Properties of Paired Helical Filaments andSenile Plaque Amyloid Fibers in Alzheimer’s Disease.- Structural and Chemical Aspects of Cortical Pathology in Alzheimer’s Disease.- Cholinergic and Non-Cholinergic Neurotransmitter Hypotheses for Alzheimer’s Disease.- Brain Topochemistry of Cholinergic and Monoaminergic Parameters in Alzheimer’s Disease.- The “Autocannibalism” of Choline-Containing Membrane Phospholipids in the Pathogenesis of Alzheimer’s Disease.- Trophic Factors and Neurologic Disease.- Neuronal Loss and Neurotransmitter Receptor Alterations in Alzheimer’s Disease.- Brain Nicotinic and Muscarinic Receptors in Normal Aging and Dementia.- Examination of Cholinergic and Neuropeptide Receptor Alterations in Senile Dementia of the Alzheimer’s Type (SDAT).- Quantitative Autoradiography and Histochemistry in the Human Brain Post Mortem.- Increased Vasopressin Production in Senescence and Dementia Due to Kidney Changes.- Clinical Aspects And Noninvasive Diagnostic Approaches.- Clinical Heterogeneity in Patients with Dementia of the Alzheimer Type.- Patterns of Cognitive Impairment in Patients with Alzheimer’s Disease and Parkinson’s Disease: Are They Similar or Different?.- Risk Factors in Alzheimer’s Disease.- Enhancing Communication for the Demented Patient and His Family.- Reaction Times in Tasks of Varying Degrees of Complexity, an Indication of the Degree and the Evolution of Mental Deterioration: A Preliminary Study.- An Intranosological Classification of Alzheimer’s Disease as a Multi-stage Dementing Process - The Basis for Individualized Therapeutic Strategies.- The Epidemiology of Alzheimer’s Type Presenile Dementia in Israel.- Dementia in Parkinson Disease.- Possible Dopaminergic Basis for Perceptual Motor Dysfunction.- Diagnostic Methods in Alzheimer’s Disease: Magnetic Resonance Brain Imaging and CSF Neurotransmitter Markers.- Neuroimaging Studies of Alzheimer’s Disease.- High Resolution Mapping of Cerebral Blood Flow in Alzheimer’s Disease.- Regional Cerebral Blood Flow in Dementing Disorders.- The Early Stages of Presenile and Senile Alzheimer’s Disease: Initial Studies of Disease Severity and Cerebral Blood Flow.- Etiological And Genetic Aspects Of Alzheimer’s And Parkinson’s Disease.- Laser Microprobe Mass Analyzer (LAMMA) - A New Approach to the Study of the Association of Aluminum and Neurofibrillary Tangle Formation.- Normal Pressure Hydrocephalus (NPH) as a Cause of Pre-Senile and Senile Dementia: The Complementary Role of Radionuclide Cysternography (RNC) and Cranial Computed Tomography (CCT) in the Early Recognition of the Treatable Patients.- Measles Virus Infection of Human Neural Cell Lines as a Model for Persistent Viral Infection of the Central Nervous System.- Brain Iron and Dopamine D2 Receptors in the Rat.- Down’s Syndrome and Alzheimer’s Disease: Are Common Genes for Human Chromosome 21 Involved in Both Disorders?.- The Natural History of Alzheimer’s Families: An Underutilized Method for Exploring Basic and Therapeutic Strategies in Age-Related Neuropsychiatric Disorders.- Biological Markers In Alzheimer’s And Parkinson’s Disease.- Biological Markers for Alzheimer’s Disease.- Acetylcholine Metabolism in Brain: Is it Reflected by CSF Changes?.- Acetylcholinesterase Activity and Somatostatin-Like Immunoreactivity in Lumbar Cerebrospinal Fluid of Demented Patients.- Monoamine Neurotransmitter Metabolites and Hydroxylase Cofactor in Alzheimer-Type Dementia and Normals.- Antibodies to Cholinergic Cell Bodies in Alzheimer’s Disease..- Nicotinic and Muscarinic Binding Sites on Lymphocytes from Alzheimer Patients.- Cholinergic Muscarinic Binding by Lymphocytes: Changes with Age, Antagonist Treatment and Senile Dementia.- Dexamethasone Suppression Test in Senile Dementia of the Alzheimer Type.- Hormone-Stimulated Adenylate Cyclase Activity in Man: Studies with Peripheral Models.- Anti-Haloperidol Antibodies and Their Auto-Antiidiotypes: Tools in the Study of Neurological Disorders.- Experimental Models Of Alzheimer’s And Parkinson’s Disease.- Pharmacological Protection Against Memory Retrieval Deficits as a Method of Discovering New Therapeutic Agents.- Neurochemical and Behavioral Alterations in Aging and in Animal Models of Alzheimer’s Disease.- Reversal of Cerebral Metabolic Deficits in Rodent Models for Aging and Alzheimer’s Disease.- Radial Maze Performance Deficits following Lesions of Rat Basal Forebrain.- The AF64A-Treated Rat as an Experimental Model for Alzheimer’s Disease: A Critical evaluation.- Histochemical and Electronmicroscopic Study of the Brain of the AF64A-Treated Rat.- A Review of the Behavioral Effects of AF64A, a Cholinergic Neurotoxin.- AF64A Induced Choiinotoxicity: Behavioral and Biochemical Correlates.- Neurobehavioral Aspects of Some Animal Models of Age-Related Neuropsychiatrie Disorders.- Dysfunction of Central Cholinergic System in Hyperkinetic Rats, Following Postnatal Anoxia.- Implantation of Alzheimer’s Disease Brain Tissue in Young Rat Brain: Parenchymal and Vascular Reactions.- Functional Properties of Septo-Hippocampal Neurons in the Rat..- Micromolar Concentrations of Neurotoxic Cations Induce Phase Separation, Aggregation and Fusion in Phosphatidylserine Containing Membranes.- MPTP-Induced Parkinsonian Syndromes in Humans and Animals.- New Drug Development, And Innovative Experimental Approaches.- Human and Animal Studies with Cholinergic Agents: How Clinically Exploitable is the Cholinergic Deficiency in Alzheimer’s Disease.- Pharmacological Activity of Novel Anticholinesterase Agents of Potential Use in the Treatment of Alzheimer’s Disease.- Sulfonyl Fluorides as Possible Therapeutic Agents in Alzheimer’s Disease: Structure/Activity Relationships as CNS Selective Cholinesterase Inhibitors.- A Novel Transdermal Therapeutic System, a Potential Treatment for Alzheimer’s Disease.- Differences in the Agonist Binding Properties of Muscarinic leGeptor Subpopulations in the Rat Cerebral Cortex and Myocardium.- Cholinoceptor Characterization Reconsidered in the Light of Diversity of Response.- Structure-Activity Relationships of RS 86 Analogues.- The Lipid Regimen.- Spatial Discrimination and Passive Avoidance Behavior in the Rat: Age-Related Changes and Modulation by Chronic Dietary Choline Enrichment.- Hippocampal Morphometry in the Rat: Age-Related Changes and Modulation by Chronic Dietary Choline Enrichment.- Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Injury.- Can Septal Grafting Facilitate Recovery from Physiological and Behavioral Deficits Produced by Fornix Transections?.- Structural Analogs of AF64A: Synthesis and Their Effects on High Affinity Choline Transport and QNB Binding.- In Vivo Evaluation of 125I-Labeled Iodoclebopride and Iodoazidoclebopride Binding to the Dopamine D2 Receptor.- Monoamine Oxidase Type B Inhibitors in Human and Animal Parkinsonism.- General Discussion.- Participants.