Pub. Date:
Springer US
Alzheimer's and Parkinson's Diseases: Strategies for Research and Development

Alzheimer's and Parkinson's Diseases: Strategies for Research and Development


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Product Details

ISBN-13: 9780306422324
Publisher: Springer US
Publication date: 06/28/1986
Series: Advances in Behavioral Biology Series , #29
Edition description: 1986
Pages: 726
Product dimensions: 0.00(w) x 0.00(h) x (d)

Table of Contents

Welcoming Address.- Alzheimer’S And Parkinson’S Disease: Anatomical, Pathological And Biochemical Aspects.- Cholinergic Systems in the Brain and Spinal Cord: Anatomic Organization and Overview of Functions.- Histopathology of the Basal Forebrain and Its Targets in Alzheimer Dementia..- Clinical, Pathological and Biochemical Aspects of Alzheimer’s Disease.- Molecular Properties of Paired Helical Filaments andSenile Plaque Amyloid Fibers in Alzheimer’s Disease.- Structural and Chemical Aspects of Cortical Pathology in Alzheimer’s Disease.- Cholinergic and Non-Cholinergic Neurotransmitter Hypotheses for Alzheimer’s Disease.- Brain Topochemistry of Cholinergic and Monoaminergic Parameters in Alzheimer’s Disease.- The “Autocannibalism” of Choline-Containing Membrane Phospholipids in the Pathogenesis of Alzheimer’s Disease.- Trophic Factors and Neurologic Disease.- Neuronal Loss and Neurotransmitter Receptor Alterations in Alzheimer’s Disease.- Brain Nicotinic and Muscarinic Receptors in Normal Aging and Dementia.- Examination of Cholinergic and Neuropeptide Receptor Alterations in Senile Dementia of the Alzheimer’s Type (SDAT).- Quantitative Autoradiography and Histochemistry in the Human Brain Post Mortem.- Increased Vasopressin Production in Senescence and Dementia Due to Kidney Changes.- Clinical Aspects And Noninvasive Diagnostic Approaches.- Clinical Heterogeneity in Patients with Dementia of the Alzheimer Type.- Patterns of Cognitive Impairment in Patients with Alzheimer’s Disease and Parkinson’s Disease: Are They Similar or Different?.- Risk Factors in Alzheimer’s Disease.- Enhancing Communication for the Demented Patient and His Family.- Reaction Times in Tasks of Varying Degrees of Complexity, an Indication of the Degree and the Evolution of Mental Deterioration: A Preliminary Study.- An Intranosological Classification of Alzheimer’s Disease as a Multi-stage Dementing Process - The Basis for Individualized Therapeutic Strategies.- The Epidemiology of Alzheimer’s Type Presenile Dementia in Israel.- Dementia in Parkinson Disease.- Possible Dopaminergic Basis for Perceptual Motor Dysfunction.- Diagnostic Methods in Alzheimer’s Disease: Magnetic Resonance Brain Imaging and CSF Neurotransmitter Markers.- Neuroimaging Studies of Alzheimer’s Disease.- High Resolution Mapping of Cerebral Blood Flow in Alzheimer’s Disease.- Regional Cerebral Blood Flow in Dementing Disorders.- The Early Stages of Presenile and Senile Alzheimer’s Disease: Initial Studies of Disease Severity and Cerebral Blood Flow.- Etiological And Genetic Aspects Of Alzheimer’s And Parkinson’s Disease.- Laser Microprobe Mass Analyzer (LAMMA) - A New Approach to the Study of the Association of Aluminum and Neurofibrillary Tangle Formation.- Normal Pressure Hydrocephalus (NPH) as a Cause of Pre-Senile and Senile Dementia: The Complementary Role of Radionuclide Cysternography (RNC) and Cranial Computed Tomography (CCT) in the Early Recognition of the Treatable Patients.- Measles Virus Infection of Human Neural Cell Lines as a Model for Persistent Viral Infection of the Central Nervous System.- Brain Iron and Dopamine D2 Receptors in the Rat.- Down’s Syndrome and Alzheimer’s Disease: Are Common Genes for Human Chromosome 21 Involved in Both Disorders?.- The Natural History of Alzheimer’s Families: An Underutilized Method for Exploring Basic and Therapeutic Strategies in Age-Related Neuropsychiatric Disorders.- Biological Markers In Alzheimer’s And Parkinson’s Disease.- Biological Markers for Alzheimer’s Disease.- Acetylcholine Metabolism in Brain: Is it Reflected by CSF Changes?.- Acetylcholinesterase Activity and Somatostatin-Like Immunoreactivity in Lumbar Cerebrospinal Fluid of Demented Patients.- Monoamine Neurotransmitter Metabolites and Hydroxylase Cofactor in Alzheimer-Type Dementia and Normals.- Antibodies to Cholinergic Cell Bodies in Alzheimer’s Disease..- Nicotinic and Muscarinic Binding Sites on Lymphocytes from Alzheimer Patients.- Cholinergic Muscarinic Binding by Lymphocytes: Changes with Age, Antagonist Treatment and Senile Dementia.- Dexamethasone Suppression Test in Senile Dementia of the Alzheimer Type.- Hormone-Stimulated Adenylate Cyclase Activity in Man: Studies with Peripheral Models.- Anti-Haloperidol Antibodies and Their Auto-Antiidiotypes: Tools in the Study of Neurological Disorders.- Experimental Models Of Alzheimer’s And Parkinson’s Disease.- Pharmacological Protection Against Memory Retrieval Deficits as a Method of Discovering New Therapeutic Agents.- Neurochemical and Behavioral Alterations in Aging and in Animal Models of Alzheimer’s Disease.- Reversal of Cerebral Metabolic Deficits in Rodent Models for Aging and Alzheimer’s Disease.- Radial Maze Performance Deficits following Lesions of Rat Basal Forebrain.- The AF64A-Treated Rat as an Experimental Model for Alzheimer’s Disease: A Critical evaluation.- Histochemical and Electronmicroscopic Study of the Brain of the AF64A-Treated Rat.- A Review of the Behavioral Effects of AF64A, a Cholinergic Neurotoxin.- AF64A Induced Choiinotoxicity: Behavioral and Biochemical Correlates.- Neurobehavioral Aspects of Some Animal Models of Age-Related Neuropsychiatrie Disorders.- Dysfunction of Central Cholinergic System in Hyperkinetic Rats, Following Postnatal Anoxia.- Implantation of Alzheimer’s Disease Brain Tissue in Young Rat Brain: Parenchymal and Vascular Reactions.- Functional Properties of Septo-Hippocampal Neurons in the Rat..- Micromolar Concentrations of Neurotoxic Cations Induce Phase Separation, Aggregation and Fusion in Phosphatidylserine Containing Membranes.- MPTP-Induced Parkinsonian Syndromes in Humans and Animals.- New Drug Development, And Innovative Experimental Approaches.- Human and Animal Studies with Cholinergic Agents: How Clinically Exploitable is the Cholinergic Deficiency in Alzheimer’s Disease.- Pharmacological Activity of Novel Anticholinesterase Agents of Potential Use in the Treatment of Alzheimer’s Disease.- Sulfonyl Fluorides as Possible Therapeutic Agents in Alzheimer’s Disease: Structure/Activity Relationships as CNS Selective Cholinesterase Inhibitors.- A Novel Transdermal Therapeutic System, a Potential Treatment for Alzheimer’s Disease.- Differences in the Agonist Binding Properties of Muscarinic leGeptor Subpopulations in the Rat Cerebral Cortex and Myocardium.- Cholinoceptor Characterization Reconsidered in the Light of Diversity of Response.- Structure-Activity Relationships of RS 86 Analogues.- The Lipid Regimen.- Spatial Discrimination and Passive Avoidance Behavior in the Rat: Age-Related Changes and Modulation by Chronic Dietary Choline Enrichment.- Hippocampal Morphometry in the Rat: Age-Related Changes and Modulation by Chronic Dietary Choline Enrichment.- Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Injury.- Can Septal Grafting Facilitate Recovery from Physiological and Behavioral Deficits Produced by Fornix Transections?.- Structural Analogs of AF64A: Synthesis and Their Effects on High Affinity Choline Transport and QNB Binding.- In Vivo Evaluation of 125I-Labeled Iodoclebopride and Iodoazidoclebopride Binding to the Dopamine D2 Receptor.- Monoamine Oxidase Type B Inhibitors in Human and Animal Parkinsonism.- General Discussion.- Participants.

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