Alzheimer's Disease - Modernizing Concept, Biological Diagnosis and Therapy

Alzheimer's Disease - Modernizing Concept, Biological Diagnosis and Therapy

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Overview

How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the 'amyloid' or 'tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Product Details

ISBN-13: 9783805598026
Publisher: Karger, S. Inc.
Publication date: 04/23/2012
Series: Advances in Biological Psychiatry Series , #28
Pages: 194
Product dimensions: 6.90(w) x 9.60(h) x 0.70(d)

Table of Contents

The Global Impact of Alzheimer's Disease Carrillo, M.C. Thies, W. (Chicago, III.) Bain, L.J. (Elverson, Pa.) 1

The Genetics of Alzheimer's Disease Schu, M.C Sherva, R. Farrer, L.A. Green, R.C. (Boston, Mass.) 15

Current Conceptual View of Alzheimer's Disease Herrup, K. (Piscataway, N J.) 30

Neuropathological Basis of Alzheimer's Disease and Alzheimer's Disease Diagnosis Schneider, J.A. (Chicago, III.) Montine, T.J. (Seattle, Wash.) Sperling, R.A. (Boston, Mass) Bennett, D.A. (Chicago, III.) 49

Diagnostic Tools: Fluid Biomarkers for Alzheimer's Disease Zetterberg, H. (Mölndal) Hampel, H. (Frankfurt a.M.) Blennow, K. (Mölndal) 71

MRI- and PET-Based Imaging Markers for the Diagnosis of Alzheimer's Disease Teipel, S. (Rostock) Sperling, R.A. (Boston, Mass.) Skudlarski, P. (Hartford, Conn.) Jack, C. (Rochester, Minn.) Hampel, H. (Frankfurt a.M.) Fellgiebel, A. (Mainz) Herholz, K. (Manchester) 80

Changing Diagnostic Concepts of Alzheimer's Disease McKhann, G.M. Albert, M.S. (Baltimore, Md.) Sperling, R.A. (Boston, Mass.) 115

Pharmacological Treatment of Alzheimer's Disease Schneider, L.S. (Los Angeles, Calif.) 122

Regulatory Requirements on Clinical Trials in Alzheimer's Disease Broich, K. Schlosser-Weber, G. Weiergräber, M. (Bonn) Hampel, H. (Frankfurt a.M.) 168

Perspectives on Alzheimer's Disease: Past, Present and Future Khachaturian, Z.S. (Potomac, Md.) 179

Author Index 189

Subject Index 190

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