The first edition of this book was described by the British Medical Journal as 'a concise and clear account of the basics of pharmacokinetics which could not be faulted in any way.' Since it was published in 1981, there has been an enormous increase in the quantity of published pharmacokinetic data. And, in addition to the great interest in pharmacokinetics in medicine, there is now a greatly increased reliance upon pharmacokinetics to help in the design and interpretation of animal toxicity tests carried out to evaluate drug safety. This expansion of the data and interest in the subject reinforces the need for this simple introductory text aimed at students of pharmacy, pharmacology, human or veterinary medicine, toxicology and drug metabolism.
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Table of Contents
List of common symbols; Introduction to pharmacokinetics; Rapid (bolus) intravenous injection; Clearance; Extraction; The measurement of clearance; Clearance, flow and extraction; Importance of site of administration; First-pass effects; Area under the curve; The concept of compartments; First-order and zero-order processes; Intravenous infusion; Partial infusion data; The single oral dose; Bioavailability and bioequivalence; Other applications; Repeated doses; Excretion of drugs in urine; Incomplete urinary excretion data; Capacity-limited processes; Capacity-limited elimination; Protein binding; Conclusion; Appendices