Analytical Profiles of Drug Substances and Excipients / Edition 1

by Harry G. Brittain

Overview

Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Analytical Profiles of Drug Substances and Excipients, brings the latest information together in one source.

Product Details

ISBN-13:	9780122608254
Publisher:	Elsevier Science
Publication date:	03/02/1998
Series:	Analytical Profiles of Drug Substances and Excipients , #25
Pages:	582
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Prior to forming the Center for Pharmaceutical Physics, Dr. Brittain was Vice President for Pharmaceutical Development of Discovery Laboratories, Inc. Before that, he served as Director of Pharmaceutical Development at Ohmeda, Inc., and also led a variety of groups within the Analytical R&D department at Bristol-Myers Squibb. Dr. Brittain is a graduate of Queens College (B.S., 1970; M.S. 1972), and of the City University of New York (Ph.D. in physical chemistry, 1975). He was a postdoctoral fellow at the University of Virginia, and has held faculty positions at Ferrum College (Assistant Professor of Chemistry) and Seton Hall University (Associate Professor of Physical and Inorganic Chemistry). He has been Adjunct Professor of Pharmaceutics at Rutgers University, and presently holds a position as Visiting Research Scientist in the Chemistry Department at Lehigh University.

Dr. Brittain has authored approximately 225 research publications and book chapters, and has edited the monographs Physical Characterization of Pharmaceutical Solids, Polymorphism in Pharmaceutical Solids, and Analytical Applications of Circular Dichroism. Dr. Brittain is a member of the editorial boards of Pharmaceutical Research, Journal of Pharmaceutical Sciences, Pharmaceutical Development and Technology PharmSci, Pharmaceutical Technology, Journal of Pharmaceutical and Biomedical Analysis, Saudi Pharmaceutical Journal, Chirality, and Instrumentation Science and Technology. He is also the Editor for the book series Analytical Profiles of Drug Substances and Excipients, and is Chairman of the USP Committee 'Excipients: Substances and Characterization as a member of the Council of Experts. Dr. Brittain was elected as a Fellow of the American Association of Pharmaceutical Sciences (AAPS) in 1991, and received the AAPS Research Achievement Award in Analysis and Pharmaceutical Quality in 1998.

Table of Contents

Prior to forming the Center for Pharmaceutical Physics, Dr. Brittain was Vice President for Pharmaceutical Development of Discovery Laboratories, Inc. Before that, he served as Director of Pharmaceutical Development at Ohmeda, Inc., and also led a variety of groups within the Analytical R&D department at Bristol-Myers Squibb. Dr. Brittain is a graduate of Queens College (B.S., 1970; M.S. 1972), and of the City University of New York (Ph.D. in physical chemistry, 1975). He was a postdoctoral fellow at the University of Virginia, and has held faculty positions at Ferrum College (Assistant Professor of Chemistry) and Seton Hall University (Associate Professor of Physical and Inorganic Chemistry). He has been Adjunct Professor of Pharmaceutics at Rutgers University, and presently holds a position as Visiting Research Scientist in the Chemistry Department at Lehigh University.

Dr. Brittain has authored approximately 225 research publications and book chapters, and has edited the monographs Physical Characterization of Pharmaceutical Solids, Polymorphism in Pharmaceutical Solids, and Analytical Applications of Circular Dichroism. Dr. Brittain is a member of the editorial boards of Pharmaceutical Research, Journal of Pharmaceutical Sciences, Pharmaceutical Development and Technology PharmSci, Pharmaceutical Technology, Journal of Pharmaceutical and Biomedical Analysis, Saudi Pharmaceutical Journal, Chirality, and Instrumentation Science and Technology. He is also the Editor for the book series Analytical Profiles of Drug Substances and Excipients, and is Chairman of the USP Committee 'Excipients: Substances and Characterization' as a member of the Council of Experts. Dr. Brittain was elected as a Fellow of the American Association of Pharmaceutical Sciences (AAPS) in 1991, and received the AAPS Research Achievement Award in Analysis and Pharmaceutical Quality in 1998.

Editorial Reviews

"Volume 25 of this series continues the long tradition of well-written and well-documented profiles of drug substances and pharmaceutical excipients that should be essential readings for the practicing pharmaceutical scientist...What makes this and the entire series of volumes a valuable work is the thoroughness of the presented data and the detail which is paid to consistency. It is hopeful that pharmaceutical scientists worldwide will help to maintain the outstanding reputation of this series by contributing profiles. The price of each volume is reasonable and can be purchased for a personal library. The entire 25 volume set should definitely be available in academic, industrial, and governmental laboratories where pharmaceutical research is being conducted." —James T. Stewart, College of Pharmacy, The University of Georgia, JOURNAL OF PHARMACEUTICAL and BIOMEDICAL ANALYSIS

from:Praise for the Series
"This volume and the entire 24 volumes are highly recommended for single individual use or by groups of scientists when placed in a corporate, government, or academic library. There is no comparable series of books that provides this important data in such a timely and meaningful manner." —James T. Stewart in JOURNAL OF NATURAL PRODUCTS

"This series was first published in 1972 and represents a very important contribution to the practice of pharmaceutical analysis...This volume represents an excellent overview of physical, chemical, and biochemical properties of some regularly prescribed drugs." —Brian J. Clark in THE ANALYST

From the Publisher

A compilation of drug substances summarizing physical and chemical data, analytical methods, routes of compound preparation, and degradation pathways. Volume 24 of the distinguished reference series profiles carbenoxolone sodium, clarithromycin, crospovidone, fluvoxamine maleate, gadoteridol, guar gum, mafenide acetate, maltodextrin, nalmefene hydrochloride, polyvinyl alcohol, sertraline hydrochloride, solasodine, starch, and tobramycin. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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