ISBN-10:
1420080113
ISBN-13:
9781420080117
Pub. Date:
04/01/2009
Publisher:
Taylor & Francis
Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers / Edition 2

Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers / Edition 2

by G.O. Evans

Hardcover

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Overview

Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers / Edition 2

10+ Years of Updates Since First Edition

Newcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition collates information widely dispersed in journals and book chapters, focusing on the most relevant literature to experimental toxicology and its distinction from human medicine.

Expands Discussion of Troponins, Lipids, and Electrolytes

In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role with interpreting data from animal studies as compared to human studies when variables can be well controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology.

Under the editorial guidance of G.O. Evans, a recognized field authority, the book presents background information on the selection and application of biochemical tests in preclinical safety assessment studies. It also assesses specific organ toxicity, such as in the liver, kidney, and thyroid, along with regulatory requirements and statistical approaches. Careful to avoid delving into overly complex detail, this text is a comprehensive, practical reference ideal for new entrants to the field. However, its broad scope and depth also make it suitable for more seasoned scientists and toxicologists.

Product Details

ISBN-13: 9781420080117
Publisher: Taylor & Francis
Publication date: 04/01/2009
Edition description: New Edition
Pages: 368
Product dimensions: 6.40(w) x 9.30(h) x 1.00(d)

Table of Contents

Introduction

General Enzymology

Assessment of Hepatotoxicity

Assessment of Nephrotoxicity

Assessment of Gastrointestinal and Pancreatic Toxicities

Fluid Balance, Electrolytes, and Mineral Metabolism

Assessment of Cardiotoxicity and Myotoxicity

Proteins

Lipids

Assessment of Endocrine Toxicity

Assessment of Neurotoxicity

Preanalytical Variables

Analytical Variables and Biosafety

Data Processing and Interpretation

References for Laboratory Animal Clinical Chemistry Data

Appendix A References for Laboratory Animal Clinical Chemistry Data

Appendix B SI Unitage and Conversions

Appendix C "Expectable" Ranges for Plasma/Serum

Appendix D General Abbreviations

Appendix E Some Common Biochemical Abbreviations

Index

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