Animal Models of Cognitive Impairment

Animal Models of Cognitive Impairment

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Taylor & Francis

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Animal Models of Cognitive Impairment

Animal models of cognitive function, including learning, memory, and attention, are critical for determining the neurobehavioral basis for cognition and for the development of new therapeutic treatments for cognitive impairment. Animal Models of Cognitive Impairment features an integrated approach that combines molecular and neurochemical approaches in translational models with behavioral and clinical applications. The text also discusses current research on genetic, lesion, pharmacological toxicant, and aging models. The book then explores the significance of this research to the treatment of various addictions and disorders such as stroke, autism, Alzheimer's, schizophrenia, and ADHD.

Product Details

ISBN-13: 9780849328343
Publisher: Taylor & Francis
Publication date: 10/26/2005
Series: Frontiers in Neuroscience Series
Pages: 400
Product dimensions: 6.12(w) x 9.25(h) x 1.00(d)

Table of Contents

Introduction; Edward D. Levin and Jerry I Buccafusco
Pharmacologic Models
Muscarinic Receptor Antagonists in Rats; Alvin V Terry, Jr.
Nicotinic Receptor Antagonists in Rats; Cindy S. Roegge and Edward D. Levin
Involvement of the NMDA System in Learning and Memory; Amir H. Rezvani
Animal Models and the Cognitive Effects of Ethanol; Merle G. Paule

Toxicologic Models
Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure; Deborah C. Rice
Developmental Behavioral Toxicity of Methylmercury: Consequences, Conditioning, and Cortex; M. Christopher Newland, Wendy D. Donlin, Elliott M. Paletz, and Kelly M. Banna
Executive Function following Developmental Exposure to Polychlorinated Biphenyls (PCBs): What Animal Models Have Told Us; Helen J.K. Sable and Susan L. Schantz
Modeling Cognitive Deficits Associated with Parkinsonism in the Chronic-Low-Dose MPTP-Treated Monkey; J.S. Schneider

Mouse Genetic Models
Cognitive Jmpairment in Transgenic Mouse Models of Amyloid Deposition; Dave Morgan
Cholinergic Receptor Knockout Mice; Lu Zhang
Assessments of Cognitive Deficits in Mutant Mice; Ramona Marie Rodriguiz and William C. Weisel

Model Applications and Future Developments
Cognitive Pharmacology in Aging Macaques; Jerry J. Buccaflisco
Cognitive Impairment following Traumatic Brain Injury; Mark D. Whiting, Anna I. Baranova, and Robert J. Jdamm
Cognitive Impairment Models Using Complementary Species; Daniel T. Cerutti and Edward D. Levin
Cognition Models and Drug Discovery; Michael W Decker

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