Annals of the New York Academy of Sciences, Immunology of Diabetes V / Edition 1

Annals of the New York Academy of Sciences, Immunology of Diabetes V / Edition 1

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Annals of the New York Academy of Sciences, Immunology of Diabetes V / Edition 1

This volume an overview of current research in the field ofimmunology as it relates to diabetes. Topics covered include:autoantibody markers for type 1 diabetes; cellular immune markersfor type 1 diabetes; animal models of type 1 diabetes; the pancreasin type 1 diabetes; genetics of type 1 diabetes; the role oftoll-like receptors and innate immunity in type 1 diabetes;cell-based therapies for type 1 diabetes; environmental andmechanistic causes of type 1 diabetes; mechanisms of beta-celldeath; role of the immune response in type 1 diabetes; and islettransplantation.

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Product Details

ISBN-13: 9781573317337
Publisher: Wiley
Publication date: 01/14/2009
Series: Annals of the New York Academy of Sciences Series
Pages: 352
Product dimensions: 6.90(w) x 9.90(h) x 0.70(d)

Table of Contents

Preface: C.B. Sanjeevi.

Part I: Special Reports:.

1. The Environmental Determinants of Diabetes in the Young(TEDDY) Study: The TEDDY Study Group and Marian Rewers.

2. Type 1 Diabetes TrialNet – An InternationalCollaborative Clinical Trials Network: Jay S. Skyler, Carla J.Greenbaum, John M. Lachin, Ellen Leschek, Lisa Rafkin-Mervis, PeterSavage, Lisa Spain, and the Type 1 Diabetes TrialNet StudyGroup.

3. What will it Take to get Therapies Approved for Type 1Diabetes?: Alexander Flemming.

Part II: The Pancreas in Type 1 Diabetes:.

4. Islet Glia, Neurons and β-cells: TheNeuroimmune-Interface in Type 1 Diabetes Pathogenesis: Hubert Tsui,Shawn Winer, Yin Chan, Dorothy Truong, Lan Tang, Jason Yantha,Geoffrey Paltser, and Hans-Michael Dosch.

5. Hedgehog signalling during expansion of human PancreaticIslet-Derived precursors: Rita Gallo, Fabio Arturo Grieco, LorellaMarselli, Elisabetta Ferretti, Alberto Gulino, Piero Marchetti andFrancesco Dotta.

Part III: Update on Animal Models of Type 1Diabetes:.

6. Humanized Mice for the Study of Type 1 Diabetes and Beta CellFunction: Marie King, Todd Pearson, Aldo A. Rossini, Leonard D.Shultz, and Dale L. Greiner.

7. Developing a Novel Model System to Target Insulin ReactiveCD8 T Cells: Gwen S. Scott, Sigal Fishman, Alon Margalit, L. KhaiSiew, Stephen Chapman, Li Wen, Gideon Gross, and F. Susan Wong.

8. GATA-2 Gene (Chr6、38.5cM) Locates Close to Idd20(Chr6、37.7cM): Lowered Expressions of the NF-κB FamilyMembers in Dendritic Cells from NOD Mice are Associated with aReduced Expression of GATA-2: Kazuma Takahashi, Jo Satoh, andYoshitomo Oka.

9. Measurement of CD8+ T-Cell Responses in Human Type 1Diabetes: Emanuela Martinuzzi, François A. Lemonnier,Christian Boitard, and Roberto Mallone.

10. Comparative Analysis of the Islet Proteome Between NOD/Ltand ALR/Lt Mice: Ping Yang, Manyu Li, Dehuang Guo, Feili Gong,Bao-Ling Adam, Mark A. Atkinson and Cong-Yi Wang.

Part IV: Genetics of Type 1 Diabetes: The NextGeneration:.

11. MicroRNA Genes: Are They Susceptibility Candidates for HumanType 1 Diabetes?: Li Zhou, Hongzhi He, Jenny X. Mi, Changgui Lia,Byung Lee, and Qing-Sheng Mi.

12. Independent Association of Tumor Necrosis FactorPolymorphism with Type 1 Diabetes Susceptibility: Hyoung Doo Shin,Sei Won Yang, Duk Hee Kim, and Yongsoo Park.

13. HLA Class I Supertypes in Type 1 Diabetic Children in anUrban Children’s Hospital: Zoltan Antal, Irene Jarchum, andTeresa P. DiLorenzo.

14. Congenic Mapping of the MHC-Linked Susceptibility to Type 1Diabetes in the NOD Mouse: at Least Two Genes Contribute to theIdd16 Effect: Yoshihisa Hiromine, Tomomi Fujisawa, Shinsuke Noso,Naru Babaya, Yumiko Kawabata, and Hiroshi Ikegami.

15. STAT4 Polymorphism is Associated with Early-onset Type 1Diabetes, but not with Late-onset Type 1 Diabetes: Hye-Soon Lee,Hyewon Park, Seiwon Yang, Dukhee Kim, and Yongsoo Park.

16. From Type 1, LADA to Type 2 Diabetes: A Continuous Spectrum'The Evidence of HLA-DQ Gene: J. Lin, Z.G. Zhou, J.P. Wang, C.Zhang, and G. Huang.

17. Molecular Scanning of the Gene for Thioredoxin, anAntioxidative and Antiapoptotic Protein, and Genetic Susceptibilityto Type 1 Diabetes: Hiroshi Ikegami, Masaya Ono, Tomomi Fujisawa,Yoshihisa Hiromine, Yumiko Kawabata, and Eiji Yamato.

18. The Risk Conferred by HLA-DR and DQ for Type 1 Diabetes in0-35 Years Age Group is not Uniform and are Different in DifferentRegions of Sweden: Carani B. Sanjeevi, Saikiran K Sedimbi, MonaLandin-Olsson , Ingrid Kockum, Åke Lernmark on behalf of theSwedish Childhood Diabetes and the Diabetes Incidence in SwedenStudy Groups.

Part V: Toll-like Receptors and Innate Immunity in Type 1Diabetes:.

19. The Circle between the Bedside and the Bench: Toll-LikeReceptors in Models of Viral Induced Diabetes: Rita Bortell, StevenC. Pino, Dale L. Greiner, Danny Zipris, and Aldo A. Rossini.

20. Toll-like Receptors and Diabetes: F. Susan Wong and LiWen.

21. Different KIRs Confer Susceptibility and Protection toLatent Autoimmune Diabetes in Adults in Latvian and Asian-IndianPopulations: Arun Shastry, Saikiran K Sedimbi, Raja Rajalingam,Ingrida Rumba, Alok Kanungo, and CB Sanjeevi.

22. Innate Immune Pathways in Virus-Induced Autoimmune Diabetes:Anjali Nair, Travis R. Wolter, Adam J. Meyers, and DannyZipris.

23. The Distribution of Adiponectin Receptors on HumanPeripheral Blood Mononuclear Cells: Terence TL Pang and ParthNarendran.

24. The Role of Toll-Like Receptors 3 and 9 in the Developmentof Autoimmune Diabetes in NOD Mice: F. Susan Wong, Changyun Hu, LiZhang, Wei Du, Lena Alexopoulou, Richard A Flavell, and Li Wen.

25. TLR Agonists Abrogate Costimulation Blockade-Induced MixedChimerism and Transplantation Tolerance: David M. Miller, ThomasThornley, Todd Pearson, Masahiro Yamazaki, Michael A. Brehm, AldoA. Rossini, and Dale L. Greiner.

Part VI: Prevention or Reversal of Type 1 Diabetes:.

26. Exendin-4 Therapy in New Onset NOD Mice Increases RegulatoryT Cell Frequency: Song Xue, Clive H. Wasserfall, Matthew Parker,Todd M. Brusko, Sean McGrail, Kieran McGrail, Marcus Moore, MarthaCampbell-Thompson, Desmond A. Schatz, Mark A. Atkinson, and MichaelJ. Haller.

27. Role of increased ROS dissipation in prevention of T1D:Lessons from the ALR mouse: Jing Chen, Aaron M Gusdon, Terri CThayer, and Clayton E Mathews.

28. Apoptotic Non-β Cells Suppress β CellAntigen-Reactive T Cells and Induce β Cell Antigen-SpecificRegulatory T Cells: Transfusion of Apoptotic Splenic Stromal CellsPrevents Type 1 Diabetes: Chang-Qing Xia, Yushi Qiu, Ruihua Peng,Jeannette Lo-Dauer, and Michael J Clare-Salzler.

29. Persistence of Residual Beta Cells and Islet AutoimmunityDuring Increasing Duration of Diabetes in NOD Mice and ExperimentalApproaches Towards Reversing New-Onset Disease With BioactivePeptides: Shiva Reddy, Carlos Chun Ho Cheung, Ryan Chau Chia Chaiand Jessica Astrid Rodrigues.

30. TGF Plasmid Construction and Delivery for the Prevention ofType 1 Diabetes: Leejin Park, Eunjig Lee, Sangkyung Lee, Minsu Lim,Hekyung Hong, Geewook Shin, and Yongsoo Park.

31. Intravenous Administration of Murine Proinsulin1 or 2Expressing Fiber-mutant Recombinant Adenovirus Vector ProtectsDiabetes in NOD Mice: Hiroaki Moriyama, Katsumi Yamada, YasuyoOkumachi, Takashi Arai, Mami Kameno, Minoru Kishi, Hisafumi Yasuda,Kenta Haraa, Koichi Yokono, and Masao Nagata.

32. IFN-α Can Both Protect Against and Promote theDevelopment of Type 1 Diabetes: F. Susan Wong and Li Wen.

33. Update on Worldwide Efforts to Prevent Type 1 Diabetes: JayS. Skyler, for the Type 1 Diabetes TrialNet Study Group.

Part VII. Environmental and Mechanistic Causes of Type 1Diabetes.

34. Tobacco exposure and diabetes related auto antibodies inchildren. - Results from the ABIS study: AnnaKarin Johansson,Göran Hermansson, and Johnny Ludvigsson.

35. Variations in Incidence of Type 1 Diabetes in DifferentMunicipalities of Stockholm: Sreevalsam Gopinath, EvaÖrtqvist, Svante Norgren Anders Green, And Carani BSanjeevi.

36. Eradication of Helicobactor pylori may trigger onset of type1 diabetes: Ai Tada, Naoko Komiya, Akira Shimada, Takeshi Katsuki,Yoichi Oikawa, and Hiroshi Itoh.

37. Diabetogenic Effects of Enteroviruses Found to be the MostPrevalent in Finnish Sewage: Paivi Klemola, Svetlana Kaijalainen,Petri Ylipaasto, and Merja Roivainen.

Part VIII: Immune Response in Islet Cell and PancreaticTransplantation:.

38. Co-transplantation of stromal cells interferes with therejection of allogeneic islet grafts: Stella Jacobson, MakikoKumagai-Braesch, Annika Tibell, Mattias Svensson, and MalinFlodström-Tullberg.

39. Anti-CD20 treatment prolongs syngeneic islet graft survivaland delays the onset of recurrent autoimmune diabetes: Changyun Hu,Songyan Deng, Wei Du, F. Susan Wong, and Li Wen.

40. Autologous hematopoietic stem cell transplantation for type1 diabetes mellitus: Júlio C Voltarelli, Carlos EB Couri, AnaBPL Stracieri, Maria C Oliveira, Daniela A Moraes, Fabiano Pieroni,Marina Coutinho, Kelen CR Malmegrim, Maria C Foss-Freitas, BelindaP Simões, Milton C Foss Elizabeth Squiers, and Richard KBurt.

41. Time Course of Islet Loss After Intraportal Transplantation:Krystian Pawelec, Maciej Tadeusz Juszczak, Anila Kumar, Steve HughPowis, and Martin Press.

Part IX: Defining the Role of Immune Response in Type 1Diabetes:.

42. Human Regulatory CD8+ T cells: the Involvement of Cytokines:Vitaly Ablamunits, Brygida C. Bisikirska, and Kevan C. Herold.

43. Type 1 diabetes versus type 2 diabetes with onset below 20years: results from an Indian multicenter study: A. G.Unnikrishnan, Eesh Bhatia, Vijayalakshmi Bhatia, Sanjay Bhadada,Rakesh Kumar Sahay, Arun Kannan, V. Kumaravel, Dipti Sarma, BantwalGanapathy, Bantwal Ganapathy, Mathew John, R. V. Jayakumar, HarishKumar, Vasantha Nair, and Carani B. Sanjeevi.

44. Conserved Epitopes in the Protein Tyrosine PhosphataseFamily of Diabetes Autoantigens: Y. Liu, J.M. Wenzlau, L. Yu, C.Patel, G.S. Eisenbarth, J.C. Hutton, and H.W. Davidson.

45. Humoral immune response to islet autoantigens in Japanesepatients with type 1 diabetes: Eiji Kawasaki, Genpei Kuriya,Tsuyoshi Satoh, Keiichiro Fujishima, Akie Moriuchi, KeikoFukushima, Masako Ozaki, Norio Abiru, Hironori Yamasaki, andKatsumi Eguchi.

46. Identification of a major humoral epitope in Slc30A8 (ZnT8):Janet M. Wenzlau, Ong Moua, Yu Liu, George S. Eisenbarth, John C.Hutton, and Howard W. Davidson.

47. SlC30A8 is a Major Target of Humoral Autoimmunity in Type 1Diabetes and a Predictive Marker in Prediabetes: Janet M. Wenzlau,Ong Moua, Suparna A. Sarkar, Liping Yu, Marian Rewers, George S.Eisenbarth, Howard W. Davidson, and John C. Hutton.

48. Prevalence of Organ Specific Autoantibodies in Childhood andAdulthood Onset Type 1 Diabetes: S. Allen, J. Huber, and D.Devendra.

49. Carboxypeptidase-H Autoantibodies Discriminate a More LatentSubset of Autoimmune Diabetes from Phenotypic Type 2 Diabetes amongChinese Adults: L. Yang, Z.G. Zhou, S.Z. Tan, G. Huang, P. Jin, X.Yan, X. Li, H. Peng, and W. Hagopian.

50. A Case of Latent Autoimmune Diabetes in Adult (Lada)Followed-Up Including Change of Reactivity to GAD65 AntibodyEpitope From IGT to IDDM Stage Over 9 Years: Taro Maruyama, AyakoKoyama, and Christiane S. Hampe.

51. The sentinel role of CD8 T cells in regulating CD4 T cellresponses to proinsulin in beta–islet cell autoimmunity:Vedran Batarelo and Ivana Durinovic-Belló.

52. Diverse FOXP3 expression in children with type 1 diabetesand coeliac disease: Anna Kivling, Lennart Nilsson, KarinFälth-Magnusson, Sofia Söllvander, Calle Johanson, andMaria Faresjö.

53. Autoreactive T cell response in CD25 negative fraction ofperipheral blood mononuclear cells from established type 1diabetes: Hiroaki Moriyama, Reiko Kotani, Atsumi Katsuta, MamiKameno, Takashi Arai, Yasuyo Okumachi, Minoru Kishi, KatsumiYamada, Hisafumi Yasuda, Kenta Hara, Koichi Yokono, And MasaoNagata.

54. Gene Expression Profiles Stratified According to the Type 1Diabetes Mellitus Susceptibility Regions: Diane Meyre Rassi,Cristina Moraes Junta, Ana Lúcia Fachin, Paula Sandrin-Garcia,Stephano Mello, Guilherme Liberato Silva, Adriane FeijóEvangelista, Danielle Aparecida Magalhães, Isabela JubéWastowski, Janaína Oliveira Crispim,. GustavoMartelli-Palomino, Ana Paula Mores Fernandes, Maria CristinaFoss-Freitas, Milton César Foss, Christiane Pienna Soares,Elza Tieme Sakamoto-Hojo, Geraldo Aleixo Silva Passos, and EduardoAntônio Donadi.

Part X: Natural History of Type 1 Diabetes:.

55. Importance of the methodological approach in the evaluationof cytokine production from peripheral blood mononuclear cell oftype 1 diabetic patients: Maria Cristina Foss-Freitas, NormaTiraboschi Foss, Diane Meyre Rassi, Eduardo Antônio Donadi,and Milton C Foss.

56. Insulitis in Human Type 1 Diabetes: Toshiaki Hanafusa andAkihisa Imagawa.

57. Immunoregulatory Pathways Controlling Progression ofAutoimmunity in NOD Mice: The Role of CTLA-4 And TGF-β:Sylvaine You, Marie-Alexandra Alyanakian, Berta Segovia, DianeDamotte, Jeffrey Bluestone, Jean-François Bach, and LucienneChatenoud.

58. Advanced Glycation Endproducts (AGEs), important mediator ofchronic complication of diabetes mellitus, induce apoptosis ofcells of pancreas: Minsu Lim, Leejin Park, Geewook Shin, HekyungHong, Incheol Kang, and Yongsoo Park.

Part XI: Short Communications:.

59. Preparation and testing of diabetes autoantibody controls: HBrooking, MJ Powell, M Amoroso, C Betterle, B Pedini, G Coco, JFurmaniak, and B Rees Smith.

60. Tumor Necrosis Factor Alpha Induced Spatial InteractionsBetween Calcium Sensing Receptor and L-type Voltage DependentCalcium Channel: Jai Parkash.

61. Tracking Down Immune Marker from Alternative System PathwayFactors of Diabetic Population: Bushra Chaudhry, Kausar Saboohi,Nazema Ahsen, and Najamul Islam.

Index of Contributors.

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