Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry

by John E. Macor

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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

  • Timely and critical reviews of important topics in medicinal chemistry

Product Details

ISBN-13: 9780123860248
Publisher: Elsevier Science
Publication date: 10/12/2011
Series: Annual Reports in Medicinal Chemistry , #46
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 624
File size: 14 MB
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Table of Contents

Part I. Central Nervous System Diseases ¨C ROBICHAUD

Chapter 1 Recent Advances in Corticotropin Releasing Factor Receptor Antagonists
Carolyn D. Dzierba; Richard A. Hartz; Joanne J. Bronson

Chapter 2 Recent Advances on the 5-HT5A, 5-HT6 and 5-HT7 Receptors
Brock T. Shireman, Pascal Bonaventure and Nicholas I. Carruthers

Chapter 3 Recent Advances in Voltage Gated Sodium Channel Blockers: Therapeutic Potential as Drug Targets in the CNS
Andreas Termin, Esther Martinborough and Dean Wilson

Chapter 4 Medication Development for the Treatment of Substance Abuse
Brian Fulton

Part II. Cardiovascular and Metabolic Diseases - STAMFORD

Chapter 5 GPR40 (FFAR1) Modulators
Julio C. Medina and Jonathan B. Houze

Chapter 6 Rho-Kinase Inhibitors for Cardiovascular Disease
Robert A. Stavenger

Chapter 7 LXR Agonists for the Treatment of Atherosclerosis - Recent Highlights
Jonathan Bennett, Andrew Cooke, Heather J. McKinnon and Olaf Nimz

Chapter 8 Glucagon Receptor Antagonists for Type II Diabetes
DuaneE. DeMong, Michael W. Miller and Jean Lachowicz

Part III. Inflammation / Pulmonary / GI ¨C BARRISH

Chapter 9 Advances Towards Dissociated Non-Steroidal Glucocorticoid Receptor Agonists
John Regan, Hossein Razavi, David Thomson

Chapter 10 Advances in the Discovery of IkB Kinase Inhibitors
William J. Pitts and James Kempson

Chapter 11 Protease Inhibitors for the Potential Treatment of Chronic Obstructive Pulmonary Disease and Asthma
Weimin Liu and Eugene Hickey

Part IV. Oncology - MYLES

Chapter 12 mTor Inhibitors in Oncology
Jeroen Verheijen, Ker Yu and Arie Zask

Chapter 13 Oncology Drug Targets in the Sphingomyelin Signaling Path
Bill Garland, Amy Cavalli and Genevi¨¨ve Hansen

Part V. Infectious Diseases - Primeau

Chapter 14 Inhibitors of Respiratory Syncytial Virus
Malcolm Carter and G. Stuart Cockerill

Chapter 15 Recent Developments in ¦Â-Lactamases and Inhibitors
Tarek S. Mansour, Patricia A. Bradford and Aranapakam M. Venkatesan

Chapter 16 Recent Development in the Treatment of Clostridium Difficile Associated Disease (CDAD)
Xicheng Sun, Joseph Guiles and Nebojsa Janjic

Chapter 17 Recent Advances in the Discovery of Hybrid Antibacterial Agents
Mike Barbachyn

Part VI. Topics in Biology - LOWE

Chapter 18 Recent Renaissance of Prostaglandin Research
Robert Burk

Chapter 19 Human Exposure and Dose Projections
Punit H. Marathe, Christine Huang and A. David Rodrigues

Chapter 20 Modeling Networks of Glycolysis, Overall Energy Metabolism and Drug Metabolism under a Systems Biology Approach
Zoltan Sarnyai and Laszlo G. Boros

Part VII. Topics in Drug Design and Discovery ¨C DESAI

Chapter 21 Contrasting the Gastrointestinal Tracts of Mammals: Factors that Influence Absorption
John DeSesso and Amy Lavin Williams

Chapter 22 The Emerging Utility of Co-Crystals in Drug Discovery and Development
Nicholas Meanwell

Chapter 23 Pregnane X Receptor: Prediction and Attenuation of Human CYP3A4 Enzyme Induction and Drug-Drug Interactions
Michael W. Sinz

Chapter 24 Formulation in Drug Discovery
Robert Strictly

Part VIII. To Market, To Market

Chapter 25 To Market, To Market - 2007
Shridhar Hegde and Michelle Schmidt

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