Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment / Edition 1

by Louis Denis

Overview

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons :o/hy such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.

Product Details

ISBN-13:	9783642457470
Publisher:	Springer Berlin Heidelberg
Publication date:	02/23/2012
Series:	ESO Monographs
Edition description:	Softcover reprint of the original 1st ed. 1996
Pages:	120
Product dimensions:	8.27(w) x 10.98(h) x 0.01(d)

Table of Contents

Some Aspects of the Molecular Endocrinology of Prostatic Cancer.- Pharmacology of Cyproterone Acetate — A Short Review.- Cyproterone Acetate — Results of Clinical Trials and Indications for Use in Human Prostate Cancer.- Biological Properties of Flutamide.- Combination Therapy with Flutamide: The Therapy of Choice from Early to Advanced Stages of Prostate Cancer.- Casodex: Preclinical Studies.- Clinical Aspects of Casodex.- Pharmacodynamics and Pharmacokinetics of Nilutamide in Animal and Man.- A Review of the Clinical Studies with Nilutamide.- Indications for Antiandrogen Treatment in Prostate Cancer.

Editorial Reviews

Reviewer: Robert B. Nadler, MD (Northwestern University Feinberg School of Medicine)
Description: This book, part of a series published by the European school of oncology, discusses the molecular endocrinology of prostate cancer and the role of antiandrogens in the management of prostate cancer. Specifically, it targets the steroidal antiandrogen cyproterone acetate and the nonsteroidal antiandrogens flutamide, nilutamide, and bicalutamide.
Purpose: The purpose of the this monograph is to define the role of antiandrogens in the management of prostate cancer. The use of antiandrogens is controversial because of their expense, side effects, and unclear clinical utility. This book nicely outlines the mechanism of action of the antiandrogens, their side effects and benefits.
Audience: This book is written for any clinician, researcher, or student in the field of prostate cancer.
Features: This book is extremely well illustrated and filled with succinct tables summarizing the key points. There is an excellent introductory chapter summarizing the molecular endocrinology of prostate cancer. There are also excellent chapters outlining the pharmacology, mechanism of action, side effects, and role of each of the antiandrogens. The book is also well referenced.
Assessment: This text is an extremely through review of the molecular biology of prostate cancer and the role of steroidal and nonsteroidal antiandrogens in the treatment of prostate cancer. This book would be invaluable to anyone with a research or clinical interest in advanced prostate cancer and the pharmacology of cyproterone acetate, flutamide, nilutamide, and bicalutamide.

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