Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules.
Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines.
Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics.
- Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs
- Provides thorough information on candida drug resistance and its remedial implications
- Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics
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About the Author
Awanish Kumar is a Professor in the Bio Technology Faculty at the National Insitute of Technology Raipur, India. He has previously held posts at the National Institute of Pharma Education & Research; McGill University, Canada; and Jawaharlal Nehru University in New Dehli. His key interests in research are the development of drug targeting methods in therapeutic treatments.
Table of Contents
Chapter 1. Introduction
Chapter 2. Host–Pathogen Interaction
Chapter 3. Antifungals Used Against Candidiasis
Chapter 4. Drug Resistance in Candida
Chapter 5. Multidrug Resistance and Transporters
Chapter 6. Potential Anticandidal Targets
Chapter 7. Drug Development Strategies
Chapter 8. Conclusion