Antiepileptic Drug Discovery: Novel Approaches

Antiepileptic Drug Discovery: Novel Approaches

Paperback(Softcover reprint of the original 1st ed. 2016)

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Product Details

ISBN-13: 9781493981748
Publisher: Springer New York
Publication date: 06/27/2018
Series: Methods in Pharmacology and Toxicology
Edition description: Softcover reprint of the original 1st ed. 2016
Pages: 386
Product dimensions: 7.01(w) x 10.00(h) x (d)

Table of Contents

Part I: Novel Approaches for the Treatment of Epilepsy

1. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy

María-Leonor López-Meraz, Jesús-Servando Medel-Matus, and Jerome Niquet

2. The Use of Anti-Inflammatory Drugs in Epilepsy

María Guadalupe Valle-Dorado, Laura Elena Córdova-Dávalos, Daniel Pérez-Pérez, Rosalinda Guevara-Guzmán, and Luisa Rocha

3. Carbonic Anhydrase and Epilepsy

Luciana Gavernet

4. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs

Luz Adriana Pichardo-Macías, Itzel Jatziri Contreras-García, Sergio R. Zamudio, Edgar Mixcoha, and Julieta G. Mendoza-Torreblanca

5. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?

Cecilia Zavala-Tecuapetla and Luisa Rocha

6. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy

Manola Cuellar-Herrera, César E. Santana-Gómez, Francia Carmona-Cruz, Daruni Vázquez-Barrón, Francisco Velasco, and Ana L. Velasco

7. Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity

Suchitra Joshi and Jaideep Kapur

8. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy

Amalia Marelli, Liliana Czornyj, Luisa Rocha, and Alberto Lazarowski

9. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery

Karla G. Carvajal Aguilera and Bryan V. Phillips Farfán

10. Gene Therapy in Epilepsy

Miguel A. López-García, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, and Sandra Orozco-Suarez

Part II: Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing the Multi-Drug Resistance Issue Epilepsy

11. Human Brain Tissue as a Model for the Study of Epilepsy

Leonardo Lara-Valderrábano, Ivette Bañuelos-Cabrera, Víctor Navarrete-Modesto, and Luisa Rocha

12. The Blood-Brain Barrier and the Design of New Antiepileptic Drugs

Gabriela Rogel-Salazar and Hiram Luna-Munguia

13. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates

Alan Talevi and Luis E. Bruno-Blanch

14. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations

Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi, and Luis E. Bruno-Blanch

15. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations

Pablo Palestro and Luciana Gavernet

16. Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies

María E. Ruiz and Guillermo R. Castro

Part III: Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery

17. Side Effects of Antiepileptic Drugs

Hana Kubova

18. Network Pharmacology and Epilepsy

Alan Talevi

19. The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development

Alan Talevi

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