Antiepileptic Drug Discovery: Novel Approaches

Antiepileptic Drug Discovery: Novel Approaches

Paperback(Softcover reprint of the original 1st ed. 2016)

$139.00
View All Available Formats & Editions
Choose Expedited Shipping at checkout for guaranteed delivery by Monday, March 25

Product Details

ISBN-13: 9781493981748
Publisher: Springer New York
Publication date: 06/27/2018
Series: Methods in Pharmacology and Toxicology
Edition description: Softcover reprint of the original 1st ed. 2016
Pages: 386
Product dimensions: 7.01(w) x 10.00(h) x (d)

Table of Contents

Part I: Novel Approaches for the Treatment of Epilepsy



1. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy


María-Leonor López-Meraz, Jesús-Servando Medel-Matus, and Jerome Niquet



2. The Use of Anti-Inflammatory Drugs in Epilepsy


María Guadalupe Valle-Dorado, Laura Elena Córdova-Dávalos, Daniel Pérez-Pérez, Rosalinda Guevara-Guzmán, and Luisa Rocha



3. Carbonic Anhydrase and Epilepsy


Luciana Gavernet



4. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs


Luz Adriana Pichardo-Macías, Itzel Jatziri Contreras-García, Sergio R. Zamudio, Edgar Mixcoha, and Julieta G. Mendoza-Torreblanca



5. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?


Cecilia Zavala-Tecuapetla and Luisa Rocha



6. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy


Manola Cuellar-Herrera, César E. Santana-Gómez, Francia Carmona-Cruz, Daruni Vázquez-Barrón, Francisco Velasco, and Ana L. Velasco



7. Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity


Suchitra Joshi and Jaideep Kapur



8. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy


Amalia Marelli, Liliana Czornyj, Luisa Rocha, and Alberto Lazarowski



9. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery


Karla G. Carvajal Aguilera and Bryan V. Phillips Farfán



10. Gene Therapy in Epilepsy


Miguel A. López-García, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, and Sandra Orozco-Suarez



Part II: Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing the Multi-Drug Resistance Issue Epilepsy



11. Human Brain Tissue as a Model for the Study of Epilepsy


Leonardo Lara-Valderrábano, Ivette Bañuelos-Cabrera, Víctor Navarrete-Modesto, and Luisa Rocha



12. The Blood-Brain Barrier and the Design of New Antiepileptic Drugs


Gabriela Rogel-Salazar and Hiram Luna-Munguia



13. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates


Alan Talevi and Luis E. Bruno-Blanch



14. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations


Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi, and Luis E. Bruno-Blanch



15. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations


Pablo Palestro and Luciana Gavernet




16. Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies


María E. Ruiz and Guillermo R. Castro



Part III: Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery



17. Side Effects of Antiepileptic Drugs


Hana Kubova



18. Network Pharmacology and Epilepsy


Alan Talevi



19. The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development


Alan Talevi

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews