The use of antisense strategies in modifying biological eventssignals a new era of pharmacotherapy. Antisense oligodeoxynucleotides and antisense RNA allow pharmacologists to design agents that are more predictable and selective in their actions. This book is a practical, state-of-the-art treatise on antisense oligodeoxynucleotide and antisense RNA technology and the potential application of these strategies in therapeutics. It describes both the advances and setbacks experienced in studying this revolutionary field of study.
Critical analyses of the specificity of the agents are featured, and the possibility of antisense oligomers acting through non-antisense mechanisms is considered.
Antisense Oligodeoxynucleotides and Antisense RNA: Novel Pharmacological and Therapeutic Agents covers these important topics:
Table of ContentsHistorical Aspects of Antisense Oligodeoxynucleotides, J.-J. Toulmé
Advances in Understanding the Pharmacological Properties of Antisense
Oligonucleotides, S. Crooke
Pharmacokinetics of Phosphorothioate Oligonucleotides and its Novel Analogs, S.
Agrawal and R. Zhang
Non-Antisense Effects of Antisense Oligonucleotides, L.M. Neckers and K. Iyer
Use of Antisense Oligodeoxynucleotides to Modulate Reproductive Behavior, M.M.
Establishing the Molecular Biology of Opioid Behavior through Antisense
Approaches, G.C. Rossi and G.W. Pasternak
Antisense Oligodeoxynucleotides Targeted to the Angiotensin System as a Novel
Strategy to Treat Hypertension, M.I. Philips and R. Gyurko
Antisense DNA Therapy of Burkitt's Lymphoma in Em-myc Transgenic Mice, E.
Regulating Genes with Antisense RNA, J. Oberstrass and W. Nellen
Development of Retroviral Vectors Expressing Antisense RNA to Inhibit
Replication of the Human Immunodeficiency Virus, B.A. Bunnell and R. Morgan
Use of Plasmid Antisense RNA Expression Vectors to Alter Neurobiological
Effects, G. Davidkova, S.-P. Zhang, L.-W. Zhou, R.A. Nichols, and B. Weiss