Antisense Oligodeoxynucleotides and Antisense RNA: Novel Pharmacological and Therapeutic Agents

Antisense Oligodeoxynucleotides and Antisense RNA: Novel Pharmacological and Therapeutic Agents

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Overview

Antisense Oligodeoxynucleotides and Antisense RNA: Novel Pharmacological and Therapeutic Agents by Benjamin Weiss

The use of antisense strategies in modifying biological eventssignals a new era of pharmacotherapy. Antisense oligodeoxynucleotides and antisense RNA allow pharmacologists to design agents that are more predictable and selective in their actions. This book is a practical, state-of-the-art treatise on antisense oligodeoxynucleotide and antisense RNA technology and the potential application of these strategies in therapeutics. It describes both the advances and setbacks experienced in studying this revolutionary field of study.

Critical analyses of the specificity of the agents are featured, and the possibility of antisense oligomers acting through non-antisense mechanisms is considered.

Antisense Oligodeoxynucleotides and Antisense RNA: Novel Pharmacological and Therapeutic Agents covers these important topics:

  • History of the early development of antisense oligodeoxynucleotides
  • How oligodeoxynucleotides have been chemically modified to increase their stability, delivery, and penetration into cells
  • Pharmacokinetic properties of antisense oligodeoxynucleotides
  • Non-antisense effects of antisense oligonucleotides
  • In vitro and in vivo model systems
  • Results of early clinical trials and the potential of agents for treating certain clinical disorders
  • The use of antisense oligodeoxynucleotides to study reproductive behavior, pain perception, hypertension, and cancer
  • The use of non-viral and viral expression vectors that encode antisense RNA sequences and their potential therapeutic applications in treating disorders involving abnormal cell growth, in inhibiting replication of HIV, and in treating a variety of neurobiological disorders

  • Product Details

    ISBN-13: 9780849385520
    Publisher: Taylor & Francis
    Publication date: 06/01/1997
    Series: Handbooks in Pharmacology and Toxicology Series
    Pages: 272
    Product dimensions: 7.00(w) x 10.00(h) x (d)

    Table of Contents

    Historical Aspects of Antisense Oligodeoxynucleotides, J.-J. Toulmé
    Advances in Understanding the Pharmacological Properties of Antisense
    Oligonucleotides, S. Crooke
    Pharmacokinetics of Phosphorothioate Oligonucleotides and its Novel Analogs, S.
    Agrawal and R. Zhang
    Non-Antisense Effects of Antisense Oligonucleotides, L.M. Neckers and K. Iyer
    Use of Antisense Oligodeoxynucleotides to Modulate Reproductive Behavior, M.M.
    McCarthy
    Establishing the Molecular Biology of Opioid Behavior through Antisense
    Approaches, G.C. Rossi and G.W. Pasternak
    Antisense Oligodeoxynucleotides Targeted to the Angiotensin System as a Novel
    Strategy to Treat Hypertension, M.I. Philips and R. Gyurko
    Antisense DNA Therapy of Burkitt's Lymphoma in Em-myc Transgenic Mice, E.
    Wickstrom
    Regulating Genes with Antisense RNA, J. Oberstrass and W. Nellen
    Development of Retroviral Vectors Expressing Antisense RNA to Inhibit
    Replication of the Human Immunodeficiency Virus, B.A. Bunnell and R. Morgan
    Use of Plasmid Antisense RNA Expression Vectors to Alter Neurobiological
    Effects, G. Davidkova, S.-P. Zhang, L.-W. Zhou, R.A. Nichols, and B. Weiss
    Index

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