Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities

Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities

by Christopher D. Gregory (Editor)

Paperback(Softcover reprint of the original 1st ed. 2016)

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Product Details

ISBN-13: 9783319818801
Publisher: Springer International Publishing
Publication date: 04/25/2018
Series: Advances in Experimental Medicine and Biology , #930
Edition description: Softcover reprint of the original 1st ed. 2016
Pages: 247
Product dimensions: 6.10(w) x 9.25(h) x (d)

About the Author


Christopher D. Gregory is Professor of Inflammatory Cell Biology and the Deputy Director of the MRC Centre for Inflammation Research at the University of Edinburgh. Professor Gregory is an active research group leader in the fields of immunology, inflammation, and cancer with a particular interest in apoptosis. He has published over 100 scientific papers and has received over 6,950 citations.

Table of Contents

Foreword.- Preface.- 1. Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.- 2. Clearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis.- 3. Micro-environmental Effects of Cell Death in Malignant Disease.- 4. Apoptotic Caspases in Promoting Cancer: Implications from Their Roles in Development and Tissue Homeostasis.- 5. Axl and Mer Receptor Tyrosine Kinases: Distinct and Non-overlapping Roles in Inflammation and Cancer?.- 6. Immunogenic Apoptotic Cell Death and Anti-cancer Immunity.- 7. Cancer Cell Death-inducing Radiotherapy – Impact on Local Tumour Control, Tumour Cell Proliferation and Induction of Systemic Anti-tumour Immunity.- 8. Novel Approaches to Apoptosis-inducing Therapies.- 9. Killing Is Not Enough – How Apoptosis Hijacks Tumor-associated Macrophages to Promote Cancer Progression.- Index.

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