"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome.
The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases.
The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis.
This book will be a valuable resource for researchers investigating the role of apoptosome-dependent cell death in cancer and other diseases, for researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance and for physicians using chemotherapeutic agents. Additionally, this book will be an important educational source for PhD students and MD students specializing in molecular and cell biology, and to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of programmed cell death.
|Product dimensions:||6.10(w) x 9.25(h) x 0.03(d)|
Table of Contents
1 Physiological and Pathological Role of Apoptosis Virve Cavallucci Marcello D' Amelio 1
2 Apoptosome Structure and Regulation Elisabetta Ferraro Claudia Fuoco Flavie Strappazzon Francesco Cecconi 27
3 Chemical Regulation of the Apoptosome: New Alternative Treatments for Cancer Kelvin Cain 41
4 Molecules That Bind a Central Protein Component of the Apoptosome, Apaf-1, and Modulate Its Activity Laura Mondrag?n Mar Orz?ez Anna Gortat Monica Sancho Angel Messeguer Mar?a Jes?s Vicent Enrique P?rez-Pay? 75
5 Regulation of Cell Death and Survival by RNA Interference - The Roles of miRNA and siRNA Paul Lingor 95
6 Beneficial Role of Taurine Against Myocardial Apoptosis During Ischemic Injury Takashi Ito Stephen W. Schaffer Junichi Azuma 119
7 BAG3 Protein: Role in Some Neoplastic Cell Types and Identification as a Candidate Target for Therapy Maria Pascale Alessandra Rosati Michelina Festa Anna Basile Morena d' Avenia Antonia Falco Gaetano Torino Maria Caterina Turco 137
8 Targeting Survivin in Cancer Therapy: Pre-clinical Studies Marzia Pennati Marco Folini Nadia Zaffaroni 147
9 Hsp 70 and Hsp 27: Emerging Targets in Cancer Therapy Anne Laure R?role Anne Laure Joly Dominique Thuringer Carmen Garrido 169
10 Role of the RNA-Binding Protein HuR in Apoptosis and Apoptosome Function Yuki Kuwano Imed-Eddine Gallouzi Myriam Gorospe 203
11 Acetylcholinesterase as a Pharmacological Target in Cancer Research Sang Eun Park Young Hyun Yoo 221
12 Putative Role of HCA66, A New Apaf-1 Interacting Protein, in the Physiopathology of NF1 Microdeletion Syndrome Patients Patricia Rigou Audrey Faye Jean-Luc Poyet 237
13 Cristae Remodeling and Mitochondrial Fragmentation: A Checkpoint for Cytochrome c Release and Apoptosis? Luca Scorrano 253
14 Apoptosome Pharmacological Manipulation: From Current Developments in the Laboratory to Clinical Implications Marcello D' Amelio Francesco Cecconi 271
15 The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury Ross Kingston 283
16 Targeting Survivin in Cancer Therapy: Clinical Considerations Tetsuhiro Tsuruma Hidekaz Kameshima Yuji Iwayama Toshihiko Torigoe Yoshihiko Hirohashi Noriyuki Sato Koichi Hirata 305